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V Bonomini

Publications and source records attributed to V Bonomini.

At least 235 records · Page 13Linked to original sources
PubMedDate not supplied

The rationale for plasmapheresis in renal graft rejection.

The present study reports on 15 transplanted patients with acute vascular rejection unresponsive to high-dose steroids, who underwent plasmapheresis treatment. Cyclophosphamide was combined with plasmapheresis in 11 patients in whom specific anti-HLA antibodies against the donor's mismatched antigens were detected. The treatment proved effective in removing the antibodies from circulation and in improving the graft function. Nine of these patients have a well-functioning graft 3 to 24 months after treatment. Plasmapheresis failed to reverse rejection in two out of the four patients where anti-HLA antibodies were not found, while the remainder have a satisfactory renal function after 18 and 32 months respectively. We conclude that in transplanted patients plasmapheresis associated with an appropriate immunosuppressive therapy may be of value in the treatment of acute vascular rejection that is unresponsive to high-dose steroids, particularly when specific anti-HLA antibodies are detected.

Antibodies, Anti-Idiotypic↗
PubMedDate not supplied

Comparative losses of free amino acids and their plasma variations in artificial substitutive programmes for chronic uraemia.

This study provides a comparative evaluation of the losses of free amino acids which take place in the various artificial substitutive therapies for chronic uraemia (conventional haemodialysis, haemofiltration, haemoperfusion, continuous ambulatory peritoneal dialysis, intermittent peritoneal dialysis). The highest loss was found during haemofiltration sessions, the lowest in continuous ambulatory peritoneal dialysis. The differing loss rates do not influence patients' plasma amino acid patterns either in the short or in the long term (up to 12 months). Moreover, no currently available artificial therapy can correct the basic uraemia-related alterations of plasma amino acid patterns.

Adult↗