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Biomedical subjects

U Retzke

Publications and source records attributed to U Retzke.

At least 73 records · Page 4Linked to original sources
PubMed1982

Hemodynamic adjusted treatment of hypertension in pregnancy. Part II: Hypotensive drugs.

If in late pregnancy hypertension persists after hypovolemia and disturbances of the microcirculation have been corrected, treatment with hypotensive drugs may be indicated. Because the mode of action of these drugs varies, we tried to put this treatment on a rational basis. Due to the different effects on uteroplacental blood flow and the fetus, only those substances should be used which cause a decrease in total peripheral resistance. In our view the uteroplacental flow increases in spite of the lower pressure level. We could prove these beneficial effects for magnesium sulfate, dihydralazine, diazoxide, and nylidrin. Thus during pregnancy these are the drugs of choice.

Antihypertensive Agents↗
PubMed1982

[Crohn's disease from the viewpoint of differential diagnosis by the gynecologist. Case report].

Typical morphological changes resulting from Crohn's disease, including hyperplasia of resident lymphatic tissue, abscesses, fistulae, adhesions, and diverticula, are described in this paper, with reference being made to a case history. The following demands are derived from the findings for gynaecological practice: 1. intestinal diagnosis for all unelucidated adnexal tumours; 2. cooperation with surgeons for surgery; 3. anal lesions should in any case be regarded as a reason to think of Crohn's disease; 4. Crohn's disease should be included into differential diagnosis, whenever pathological alterations are recordable from the intestines with no conspicuous findings from internal genitals on exploratory laparotomy.

Adult↗
PubMed1981

[Problems of late formation of a radiation-induced vesico-vaginal fistula. Case report].

Described in this paper is a large urinary fistula which developed 38 years after Wertheim's radical hysterectomy and percutaneous irradiation. The patient's condition was improved by supravesical urine discharge through anastomosis between ureter and sigma. Discussed are conditions required for adequate uretero-sigmoidostomy. Good therapeutic results may justify, in certain cases, uretero-sigma anastomosis, despite a history of irradiation and poor general condition.

Colon, Sigmoid↗
PubMed1981

[Cardiovascular action of dipyridamole in advanced pregnancy (author's transl)].

Quantitative sphygmometry was used to check the cardiovascular action of an intravenous injection of 30 mg of dipyridamole in ten women, between the 31st and 38th weeks of pregnancy. Circulation was intact in all of them, but there was suspicion of intra-uterine foetal retardation. Moderate decline in arterial mean blood pressure was paralleled over a short period of time by increase in heart rate, stroke volume, and cardiac output. Overall peripheral resistance dropped with significance and caused, with some probability, increase in uterine perfusion. Hence, dipyridamole proved suitable for intra-uterine reanimation.

Adult↗
PubMed1980

[Hypertension and hormonal contraceptives].

After several years the intake of hormonal contraceptives causes a slight increase of the arterial blood pressure in the non-hypertensive region in all women. The incidence rate of real hypertensions is 1.8 to 3 times as high as users, compared with the non-users. The cause of the increase of blood pressure is not exactly known. The estrogen-induced changes of the renin-angiotensin-aldosterone-system are most probable. Conclusions for the first prescription, the frequency of controls of blood pressure and the behaviour in the appearance of a hypertensive reaction are reported. It is particularly warned of antihypertensive therapy and permanent intake of the "pill".

Adult↗
PubMed1980

[The cardiovascular effect of diisopropylaminhydrochloride (Disotat) in non-pregnant hypertensive women].

With the help of the quantitative sphygmometry and the unbloody graphic registration of the arterial pressure the hemodynamic effect of diisopropylamine hydrochloride (disotat) was investigated in 10 non-pregnant hypertensive patients. After a rapid intravenous application of 100 mg diisopropylamine hydrochloride (DIIPA) within 10 minutes after injection a statistically significant decrease of the systolic pressure by 15%, of the diastolic pressure by 9% and of the arterial medium pressure by 15% developed. Thus the blood pressure amplitude was restricted by 25%. Connected with the decrease of the pressure was a significant decrease of the stroke volume by 22% and of the cardiac output by 19%. The total peripheral resistance increased statistically uncharacteristically by 13% in comparison to the initial value. The courses of the curves show that in all parameters during the 45-minute observation duration the initial values are striven for, however, without reaching them in every case. Thus the decrease of pressure induced by bolus injection of DIIPA independent on the existence of pregnancy is always accompanied by a decrease of the output volumes of the heart and the increase of the total peripheral resistance.

Adult↗
PubMed1980

[Experience obtained from use of endoprotheses in treatment of ureterostenosis (author's transl)].

Reported in this paper is the authors' own experience obtained from treatment of 25 cases of severe ureterostenosis, using plastic endoprotheses (splints), according to a technique proposed by Schmitz and Hegemann, 1966. Ascending infection did not occur at all. The disputed method may be used in exceptional situations to get to grips with postsurgical or postradiological ureterostenosis, a condition not fully avoidable yet. Such exceptions may be claimed for patients to whom uretero-surgery would be an intolerable stress or for those on whom pharmacotherapy, using glucocorticoids and antibiotics, has failed.

Female↗
PubMed1980

[Behaviour of cardiovascular system during obstetric neuroleptanalgesia, using droperidol/fentanyl (author's transl)].

Intravenous injection of 2.5 mg of droperidol and 0,05 mg of fentanyl to ten women with clinically intact cardiovascular system in advanced pregnancy and the cardiovascular effects of such injection were studied by means of quantitative sphygmometry. - Mean arterial blood pressure was found to drop slightly but with significance, while the blood pressure amplitude went up. Heart rates remained largely constant. Significant increase in cardiac output, consequently, resulted solely from increase in stroke volume. Total peripheral resistance was reduced with significance. Medication, using the above combination of drugs, may be recommended for obstetric analgesisa, because of its favourable impact in terms of hemodynamics.

Cesarean Section↗
PubMed1980

[Circulatory effects of xanthinol nicotinate in advanced pregnancy (author's transl)].

Xanthinolnicotinate is a vasostimulant substance which is recommended to improve blood flow in the treatment of placental insufficiency. Quantitative sphygmometry with non-invasive graphic recording of arterial blood pressure was used in an attempt to study the effects of intravenous infusion of 300 mg of xanthinolnicotinate (Jupal) on the cardiovascular systems of ten women in advanced pregnancy with suspicion of intra-uterine foetal retardation. Their circulation remained basically unaffected, except for transient initial rise in pulse rate and cardiac output as well as decline of total peripheral resistance. However, additional blood supply to the skin and resulting shift in blood volumes may well provide a possibility of uteroplacental hypoperfusion, at least in cases in which perfusion had been restricted before. Administration of xanthinolnicotinate during pregnancy, therefore, cannot be recommended against the background of present knowledge.

Adult↗
PubMed1979

[The haemodynamic principle of action of diazoxide (hypertonalum) in the treatment of acute hypertensive crises in late pregnant women (author's transl)].

In ten hypertensive late pregnant women with passing crises of hypertension cardiovascular analysis with the method of quantitative sphygmometry, the unbloody recording of the blood pressure and the direct electronic measuring of the pulse wave velocity were made before and after the intravenous injection of 300 mg Diazoxid (Hypertonalum). This drug is recommended to the treatment of severe preeclampsia and eclampsia because of lessening the arterial blood pressure and the total peripheral resistance, increasing the heart rate, stroke volume and cardiac output.

Acute Disease↗
PubMed1979

[The value of magnesium sulfate in intensive care of severe toxemias of pregnancy (author's transl)].

A view on the employment of magnesium sulfate in pregnancy is given and the statement of the cardiovascular changes before, during and after the intravenous infusion of 4,0 g magnesium sulfate in ten hypertensive late pregnant women. The drug induces a mild decrease of arterial blood pressure with a distinct increase of stroke volume, cardiac output, heart rate, heart work and the heart's power. The pathologically increased total peripheral resistance is reduced. These hemodynamic effects are very favourable concerning intensive care of severe toxemias of pregnancy.

Adult↗
PubMed1979

[Dilatol for hypertension therapy in pregnancy (author's transl)].

Dilatol (Nylidrin), a betamimetic used for tocolysis, was applied to ten hypertensive women in advanced pregnancy and produced in them characteristic effects with favourable impact upon oxygen supply to the foetuses, such as significant lowering of diastolic pressure, decrease in total peripheral resistance which reflected increase in uteroplacental blood flow, as well as rises in heart rate, stroke volume, and cardiac output. Nylidrin, therefore, may be recommended as a hypotensive drug in the treatment of arterial hypertension in pregnancy.

Adult↗
PubMed1978

[Suitability of mephentermine for the management of arterial hypotension in pregnancy].

10 late pregnant women with hypotension were examined before and after the intravenous injection of 30 mg mephentermin with the method of quantitative sphygmometry, the bloodless graphic registration of the arterial blood pressure and direct electronic timing of pulse wave velocity. Systolic and diastolic blood pressure increase significantly. The cause of this rise in arterial blood pressure is the increase of stroke volume exclusively. Heart rate and total peripheral resistance remain constant. This hemodynamic mode of action is a favourable one in regard to protection of uteroplacental blood flow. Therefore mephentermin is suitable for treatment of hypotension in pregnancy.

Drug Evaluation↗
PubMed1978

[Cardiovascular effect of 15(S)-15-methyl-prostaglandin F2alpha].

The reaction of the cardiovascular system on one intramuscular injection of 250 microgram 15-methyl-prostaglandin F2alpha was examined in 14 normotensive healthy pregnant women between 7th and 11th weeks of gestation with the method of quantitative sphygmometry with unbloody graphic recording of arterial blood pressure and direct electronic determination of velocity of aortic pulse wave. The tests were done in 10 patients in intervals of 5 minutes for one hour and in 4 subjects for 12 hours in intervals of one hour. Systolic blood pressure remains nearly constant, but diastolic blood pressure increases and then decreases significantly. Heart rate decreases significantly. Aortic pulse wave velocity decreases in a characteristic manner. Analogous to the biphasic behaviour of blood pressure cardiac output decreases significantly, but then increases insignificantly. The inverse changes of total peripheral resistance are insignificant. Comparing these reactions with the cardiovascular effects of prostaglandin F2alpha or E2, 15-methyl-prostaglandin F2alpha shows the smallest circulatory alterations.

Adult↗