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Biomedical subjects

U Pedersen

Publications and source records attributed to U Pedersen.

34 records · Page 2Linked to original sources
PubMed1984

Rheumatoid arthritis of the crico-arytenoid and crico-thyroid joints: a radiological and clinical study.

Low-voltage neck radiography and indirect laryngoscopy was performed in 22 randomly selected rheumatoid patients with the purpose of detecting intralaryngeal arthritis. Radiographic evidence of erosive arthritis of the crico-arytenoid (CA) joints was found in 45% of the patients. Clinical acute CA arthritis without erosive changes was present in two patients, the overall incidence of CA arthritis being 55%. The incidence was higher in females (65%) than in males (20%). The CA arthritis was asymptomatic in 58% of the patients. Radiography revealed osseous destruction at the crico-thyroid joint in four females.

Adult↗
PubMed1984

Central corneal thickness in osteogenesis imperfecta and otosclerosis.

The central corneal thickness was measured in 53 patients with osteogenesis imperfecta. The average thickness was found to be 0.443 +/- 0.003 (SEM) mm. This value was significantly lower than the central corneal thickness in 35 patients with otosclerosis (0.515 +/- 0.004 mm) and in 35 sex- and age-matched normal control subjects (0.522 +/- 0.004 mm). No difference in corneal thickness between otosclerosis and controls was observed. Measurements of the central corneal thickness may be of great value in the diagnosis of osteogenesis imperfecta.

Adolescent↗
PubMed1984

Hearing loss in patients with osteogenesis imperfecta. A clinical and audiological study of 201 patients.

Clinical otological features, hearing status and middle ear function in 201 patients with osteogenesis imperfecta are presented. The study covered 76% of the expected total number of patients with osteogenesis imperfecta in Denmark. 78% of the patients exhibited an autosomal dominant inheritance pattern with an almost 100% penetrance. In 39% of the ears examined, a conductive or mixed hearing loss was found. Sensorineural hearing loss or anacusis was seen in 11% of the ears. In most cases the onset of hearing impairment was noted in the second or third decade and progressing with increasing age, especially after the age of 60. Tympanometry and acoustic reflex measurements suggested that the cause of conductive or mixed hearing loss was stapedial fixation and in a few cases ossicular discontinuity due to aplasia or fracture of the stapedial crura. Findings during stapedectomy in 32 patients confirmed these assumptions.

Acoustic Impedance Tests↗
PubMed1983

HLA-A, -B, -C antigens in otosclerosis.

One hundred unrelated, randomly chosen, consecutive patients with otosclerosis, verified by operation, were typed for HLA-A, -B, -C antigens. No significant association between HLA-A, -B, -C antigens and otosclerosis was found.

Adult↗
PubMed1983

Stapedectomy in osteogenesis imperfecta.

Operative findings and results of stapedectomy in 32 patients (43 ears) with osteogenesis imperfecta are presented. The stapes footplates were in many ears thick and of a very soft consistency. In all the operated ears we found the stapes footplates fixated in the oval window. Brittle and atrophic stapes crura were a common finding, but in only 5 ears fractures of the crura were observed. A thick and vascular middle ear mucosa was seen in several ears. Although the middle ear proved quite different from that of otosclerosis, no major difficulties and no serious complications occurred during stapedectomy. Both the immediate postoperative hearing gain and the long-term hearing results were, in general, satisfactory. Our study supports the statement of others, that stapedectomy in osteogenesis imperfecta is a safe and reasonable alternative to hearing aids.

Adolescent↗
PubMed1981

Diagnostic value of brush biopsy in suspected bronchial carcinoma with the use of the flexible fibre bronchoscope.

In a 12-month period, brush biopsy through a fibreoptic bronchoscope was performed on 125 consecutive patients who were clinically or radiographically suspected of lung cancer. Of the patients, 62 appeared to have lung cancer. Cytological analysis of the brush-biopsy specimens was positive in 69%. A total of 58% had positive biopsy, and 58% had cancer cells in the bronchial secretion aspirated during the bronchoscopy. Thirty-five per cent had positive mediastinoscopy. When the methods of examination were combined, the diagnosis could be established in 90% of the patients. The study shows that brush biopsy and cytological analysis, in combination with the other methods of examination, increase the diagnostic sensitivity in bronchoscopically visible tumours. In bronchoscopically invisible tumours, brush cytological analysis, together with the study of bronchial secretion and fine-needle puncture, is the most effective diagnostic method. The diagnostic possibilities can presumably be further improved by the use of fluoroscopic control in two places during the bronchoscopy.

Adult↗
PubMed1980

Allergic perennial and non-allergic, vasomotor rhinitis treated with budesonide nasal spray.

A recently synthetized, highly active, non-halogenated steroid, budesonide, in the form of a nasal spray was tested on 21 patients with an allergy demonstrated by means of cutaneous or RAST tests and 15 patients without allergy; these patients were further divided into two groups, 22 with nasal eosinophillia and 14 patients without. There was a significant effect on both patients with vasomotor as well as allergic rhinitis, and in patients with nasal eosinophilia, while this was not the case in the group without eosinophilia. Nasal eosinophilia must be considered an inexpensive and important diagnositic tool for the clarification of perennial rhinitis.

Adolescent↗
PubMed1979

Bone mineral content in osteogenesis imperfecta tarda and in otosclerosis.

In 22 patients with osteogenesis imperfecta and in 63 patients with otosclerosis the bone mineral content in peripheral bones was determined by photon absorptiometry. The bone mineral content proved significantly reduced in patients with osteogenesis imperfecta as compared with normals and with patients with otosclerosis. In the latter patients the bone mineral content was normal. These findings support the assumption that stapedial fixation in otosclerosis and in osteogenesis imperfecta is of different aetiology.

Adolescent↗
PubMed1979

Surgical findings and results of stapedectomy in patients with osteogenesis imperfecta.

Nine patients with osteogenesis imperfecta tarda and stapedial fixation (12 ears) are presented. Surgical findings as well as the immediate and long-term results of stapedectomy are described and compared with the results of previous authors. We found firmly fixed footplates in all 12 ears. Only 2 ears had thick and soft footplates. In 10 ears the stapes crura were abnormally slender and brittle, but only 1 had fractured. In 4 ears a troublesome bleeding tendency occurred during the operation. Both the immediate and the long-term hearing results were in general satisfactory.

Adult↗
PubMed1979

Serum calcitonin and bone mineral content in patients with osteogenesis imperfecta.

Serum calcitonin and bone mineral content in the forearm, measured by photon absorptiometry, were investigated in 21 patients with osteogenesis imperfecta tarda. The bone mineral content was significantly reduced as compared with normal controls, whereas the bone mineral content corrected for bone width was normal in adult patients but subnormal in children and young adults. Serum calcitonin did not differ significantly from that in normal individuals and no relation was found between serum calcitonin and bone mineral content.

Adolescent↗
PubMedDate not supplied

The treatment of perennial rhinitis with a new, non-halogenated, topical, aerosol packed, steroid, Budesonide.

The investigation of a recently synthesized non-halogenated steroid with a high local anti-inflammatory effect and low systemic glucocorticoid effect, on 36 patients with perennial rhinitis was carried out using a double-blind, cross-over technique, where the patients were treated with an aerosol spray containing a concentration corresponding to 200 micrograms/day and 400 micrograms/day of the active compound Budesonide, as well as placebo. There was a significantly better effect from the active compound than from placebo. A dosage-dependent effect was demonstrated for the symptoms nasal blockage and nasal discharge, while this was not so for sneezing bouts. No effect was observed on the function of the suprarenal glands. Local side effects were few and of no importance.

Administration, Topical↗
PubMedDate not supplied

Histomorphometric analysis of iliac trabecular bone in otosclerosis.

With the aim of investigating whether patients with otosclerosis suffer from a generalized bone disorder, a histomorphometric analysis of trabecular bone from the iliac crest was performed. Iliac crest biopsies from 10 patients with otosclerosis and 20 normal controls were obtained after tetracycline double labelling and examined by histomorphometry. No significant differences were found in the estimates of density and remodeling of bone between patients and sex and age-matched normal controls. Qualitatively the bone specimens showed no signs of any generalized bone disorder.

Adult↗