Search PubMed⌕ Search

Biomedical subjects

U Mayr

Publications and source records attributed to U Mayr.

At least 55 records · Page 3Linked to original sources
PubMed1985

[A new 3-dimensional imaging method in computed tomography].

A new imaging method for computerized tomography is presented and some examples are demonstrated. The method is based on the collection of all image data of a chosen block of tissue and enables the examiner to perform multiplanar reconstructions of high quality in any direction, even in oblique planes. In order to achieve a better orientation, the block of tissue can also be visualized at the same time on the reconstruction.

Aged↗
PubMed1985

Multiple intracranial metastases from a prolactin secreting pituitary tumour.

A 28 year old man presented with partial hypopituitarism and signs of a pituitary tumour. A chromophobe adenoma was partially removed by right frontal craniotomy. Seven years later complete hypopituitarism and hyperprolactinaemia were documented, at which time there was no evidence of tumour recurrence of CT scan. The patient was treated with bromocriptine but the pituitary tumour redeveloped a year later. Nine years after the original operation the first metastasis was demonstrated together with very high prolactin levels. The intracranial metastasis, and the pituitary tumour were removed at a second craniotomy following which the prolactin concentration fell. Further metastases developed subsequently and the patient died 12 years after the initial diagnosis. At autopsy multiple metastases were found in the brain, tumour cells were present in the subarachnoid space and in cerebral veins. The pituitary tumour and secondaries were shown by immunocytochemistry to contain prolactin but not ACTH or growth hormone. This appears to be the third well documented case of a metastasizing, prolactin secreting pituitary tumour.

Adenoma, Chromophobe↗
PubMed1985

The rigid spine syndrome--a myopathy of uncertain nosological position.

Four patients meeting the clinical criteria of the rigid spine syndrome are presented; they are one girl with a positive family history and three boys. Clinical and histological findings are discussed in relation to the 14 cases of rigid spine syndrome reported in the literature. The delineations of the syndrome from other benign myopathies with early contractures are discussed suggesting that the rigid spine syndrome probably does not represent a single nosological entity.

Adolescent↗
PubMed1984

[Possibilities and limits of cranial computerized tomography for clinical psychiatry].

The interpretation of the computer-tomogramm is of practical value for diagnostic, therapeutic and prognostic aspects (Seitz [21]). Brain-atrophy is a pathomorphological change caused by a number of facts. Only the consideration of the patient's age, the degree of hydratation, serious internal or neurological diseases, endo- or extotoxic variables respectively, postnarcotic incidents or minimal brain damage allows an interpretation in accordance with the psychopathological symptoms.

Adult↗
PubMed1983

Affinity labelling of the allosteric site of the L-lactate dehydrogenase of Lactobacillus casei.

Kinetic investigations employing the substrate analogues 2-oxoglutarate and phospho(enol)pyruvate indicate that the allosteric L-lactate dehydrogenase (EC 1.1.1.27) of Lactobacillus casei has a non-catalytic pyruvate-binding site to which, in addition to pyruvate, the allosteric effector fructose 1,6-bisphosphate can also be found. A modification using the 14C-labelled substrate analogue 3-bromopyruvate induces a loss of regulation by fructose 1,6-bisphosphate. The histidine residue labelled by 3-bromopyruvate is homologous to histidine-188 which is part of the anion-binding site of the non-allosteric vertebrate L-lactate dehydrogenases. Thus, the allosteric site of the allosteric L-lactate dehydrogenases corresponds to the anion-binding site of the non-allosteric vertebrate enzymes.

Affinity Labels↗
PubMed1983

The complete primary structure of the allosteric L-lactate dehydrogenase from Lactobacillus casei.

The polypeptide chain of the allosteric L-lactate dehydrogenase (EC 1.1.1.27) of Lactobacillus casei consists of 325 amino acid residues. Despite the strikingly different enzymatic characteristics of the allosteric L-lactate dehydrogenase of L. casei and of the non-allosteric vertebrate enzymes, the sequence of the allosteric enzyme shows a distinct homology with that of the non-allosteric vertebrate enzymes (average identity: 37%). An especially high sequence homology can be identified within the active center (average identity: 70%). A clear deviation of the L. casei enzyme from the vertebrate enzyme is the lack of the first 12 amino acid residues at the N terminus and an additional 7 amino acid residues at the C terminus. The localization of the binding site of the allosteric effector D-fructose 1,6-bisphosphate and pH and effector-induced changes of the spectroscopic properties are discussed on the basis of the primary structure.

Amino Acid Sequence↗
PubMed1983

Non-traumatic intracerebral haemorrhage. Prognostic implications of neurological and computer-tomographical findings in 100 consecutive patients.

One hundred cases of non-traumatic intracerebral haemorrhage were studied retrospectively. The mortality was 41%, although however, the cause of death in 10% of the cases was not directly related to the intracerebral haemorrhage. Clinical neurological and CT findings available in the first few hours after the admission of the patients were selected for the statistical analysis, using a linear stepwise discriminant analysis including jack-knife classification and a simple independence model for the variables. The results indicate that the outcome can be predicted with relatively great accuracy in individual patients, and that the level of consciousness on admission and the age of the patient are the most important factors for prognosis. The addition of CT-based variables did not achieve any significant improvement in the accuracy of the prediction of the outcome.

Adolescent↗
PubMed1983

[Corpus callosum agenesis and epilepsy in 2 brothers].

We report on two brothers with focal epileptic seizures and agenesia of the corpus callosum. The diagnosis of agenesia of the corpus callosum in both was made by CT, both brothers were retarded and both showed focal phenomena which can be interpreted as a consequence of the lacking connection between the two hemispheres. One of the patients showed a remarkable focal miniature spike and wave periodicity in the EEG. Neither of the parents had matching abnormalities.

Adult↗
PubMed1982

Inducibility of human beta-interferon gene in mouse L-cell clones.

Transfer of a 36-kilobase piece of human DNA containing the beta-interferon (IFN-beta) gene into mouse Ltk-cells leads to transient expression of human interferon even without an exogenous inducer. A low level of human interferon expression is also found in most stable clones containing the transferred DNA. With double-stranded RNA or Newcastle disease virus (NDV) as inducer, human interferon expression is greatly increased. The induced transcript is identical to normal human IFN-beta mRNA. Neighbouring genes contained on the transferred DNA are co-induced but are not essential for the production of human interferon in mouse L cells.

Clone Cells↗
PubMed1982

Supratentorial extracerebral cysts of the middle cranial fossa. A report of 23 consecutive cases of the so-called temporal lobe agenesis syndrome.

23 cases of supratentorial extracerebral cysts of the Sylvian fissure in children and adult patients are reported. There were 21 male and 2 female patients and the medial age was 15 years (range 2--60 years). The cysts were located in the left middle cranial fossa in 18 cases, in two cases there were bilateral cysts and three patients only had right-sided lesions. In 14 patients the presence of the cyst was uncomplicated. In two of these patients the cyst was detected only incidentally. Four patients had subdural haematomas in addition to the cyst. Two patients had subdural haematomas and were hydrocephalic as well. Three patients had large cysts and hydrocephalus. We did not encounter intracystic bleeding. Operation on the cysts by uncapping them was done in four cases. In all four instances histological examination of the cyst wall revealed that it was composed of arachnoid. Uncapping of the cyst was not followed by its diminution in any of the four patients. It seems that uncapping of such cysts is not a helpful treatment and that surgical treatment in our cases should have been restricted to complications such as subdural haematomas and hydrocephalus. A search for better operative methods for the treatment of large extracerebral supratentorial cysts of the middle cranial fossa should be undertaken.

Adolescent↗