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Biomedical subjects

U Maier

Publications and source records attributed to U Maier.

121 records · Page 7Linked to original sources
PubMed1981

[Rate of pregnancies after homologous insemination. Improvement of sperm motility with prostaglandin F2-alpha].

The effect of prostaglandin F2-alpha on sperm motility in vitro was studied on 26 pathologic sperm samples. A highly significant increase of sperm motility was observed after addition of a physiologic concentration i.e. 2500 ng/ml to the sperm samples. Sperm motility was improved quantitatively as well as qualitatively. The percentage of motile sperms in the sperm samples which responded to prostaglandin F2-alpha was X = 32.8% and in the controls X = 15.6%. Highly concentrated prostaglandin F2-alpha did not affect sperm motility. The mechanism of action and therapeutic implications of prostaglandin F2-alpha in vitro are discussed in the view of activation of sperm motility in native and kryopreserved ejaculates prior to homologous insemination.

Female↗
PubMed1981

[The effect of highly purified swine pancreatic kallikrein on sperm motility after cryopreservation].

The effect of kallikrein on sperm motility in cryopreserved ejaculates was investigated. The study was productive of the following results: 1. Cryopreservation of ejaculates is followed by a significant loss of sperm motility. 2. Kallikrein is not effective when added to the ejaculates before cryopreservation. 3. Incubation of cryopreserved ejaculates with kallikrein (5 KU) and serum after thawing significantly inhibits the loss of motility due to cryopreservation in case the initial motility is normal or moderately reduced. Kallikrein is ineffective on sperm motility in ejaculates with low initial sperm motility.

Animals↗
PubMed1980

[The accuracy of transrectal aspiration biopsy in routine diagnosis of prostatic carcinoma].

Over a period of four years 352 patients suspected of having a carcinoma of the prostate were investigated and 463 cytological and 343 histological examinations were undertaken. In 340 cases the cytological findings on transrectal aspiration biopsy according to Franzen [14] were compared with the histological findings on transperineal punch biopsy. This comparison showed an accuracy of 64.5% and if the PAP III findings were included, of 76.6% in diagnosing prostatic carcinoma by the cytological method. Since the majority of cases were first biopsies and a repeat biopsy was not made in view of the positive punch findings, the chances of detecting a carcinoma of the prostate by aspiration biopsy alone theoretically increase to almost 90%. The reasons for failures in concurrence of findings by the two methods are discussed.

Biopsy, Needle↗
PubMed1980

[Treatment of infertile couples--an interdisciplinary task (author's transl)].

The results obtained by closest cooperation between gynaecologist and andrologist in the treatment of sterile marriages are reported. 127 couples were treated over a period of 20 months. Almost 100% of the males and 60% of the females were sub- or infertile. Treatment of both partners was meticulously coordinated in order to increase the success ratio. Interdisciplinary cooperation seemed to be advantageous particularly in homologous insemination. 23 pregnancies were achieved, i.e. 18.1%, despite the unpromising nature of this negatively selected material.

Adult↗
PubMed1980

[The value of exfoliative cytology of the urine in the diagnosis of bladder tumors].

It is reported on the cytological and histological results of 253 bladder tumors. There was an exact correspondence of the results in 80.3%; in 11.4% it was not possible to prove the existence of the bladder tumor cytologically. Most of these were low-grade malignant tumors. In 8.3% of the cases the results were obtained through PAP III according to the scheme of Papanicolaou.

Adenocarcinoma↗
PubMedDate not supplied

Correlation between gamma seminoprotein in seminal plasma and ejaculate parameters.

Gamma seminoprotein (G-SM) levels in seminal plasma were determinated in 62 ejaculates using an enzymimmunoassay. There was no statistical significant difference in G-SM between men with normozoospermia (n = 14), asthenozoospermia (n = 17), OAT-syndrome (n = 18) and azoospermia (n = 13). Also there was no correlation of G-SM levels in those samples with normal (n = 14) or pathological (n = 35) motility and normal (n = 17) or pathological (n = 32) swelling test. Ejaculates with high viscosity (n = 12) showed similar G-SM levels than those with normal (n = 50) viscosity. According to these results seminal G-SM levels does not appear to provide an useful marker for evaluation of male fertility.

Ejaculation↗
PubMedDate not supplied

Oral pentoxifylline in therapy-resistant idiopathic OAT syndrome.

After previous treatment failure using tamoxifen either alone or in combination with kallikrein, 25 patients with idiopathic oligoasthenoteratozoospermia (OAT syndrome) were subjected to 3 months of treatment with pentoxifylline at a dosage of 1200 mg/day. The only statistically significant (p < .008) improvement detected in the post-therapeutic spermiograms was an increase of normal forms. All other ejaculate parameters (density, motility, swelling test, penetration test) remained unchanged, and there was only one post-therapeutic pregnancy. It would appear the pentoxifylline after failure of established treatment modalities is not a therapy of choice in idiopathic OAT syndrome.

Administration, Oral↗
PubMedDate not supplied

Penetration capacity of spermatozoa from patients with oligoasthenoteratozoospermia into bovine cervical mucus before and after therapy with kallikrein.

Due to the high degree of subjectivity involved in quantifying sperm motility by light microscopy, it appeared of interest to compare the results obtained with a bovine mucus penetration test (Penetrak) to those of routine laboratory measurement before and after therapy with kallikrein (600 U/day). The study included 45 patients with oligoasthenoteratozoospermia (OAT syndrome) in the absence of genitourinary pathology or abnormal serum hormone levels. Infertile partnership has lasted for a mean of 3.2 years. Analysis of spermiograms and the penetration test were performed before and after 3 months of treatment. Neither of these techniques revealed significant alteration after treatment, nor was there a demonstrable success during the observation period in terms of pregnancy. Judging from these results, (1) kallikrein has no effect in patients with OAT syndrome and (2) the penetration test provides no additional information on the biological quality of ejaculate.

Adult↗
PubMedDate not supplied

Effect on prostaglandin F 2 alpha on sperm motility in vitro.

The effect of prostaglandin F 2 alpha (PGF2 alpha) on sperm motility in ejaculates from 53 subfertile men was investigated. The addition of PGF2 alpha in a concentration of 25 00 ng/ml isotonic salt solution to sperm samples resulted in a highly significant (p less than 0.025) increase in sperm motility; however, only two out of three samples responded in this way, the remainder being unaffected. Mean progressive sperm motility in responders increased by 32.8% of baseline value (determined 2h after liquefaction). In higher concentrations (25 000 ng/ml aliquots), PGF2 alpha was ineffective.

Dinoprost↗