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Biomedical subjects

U Kunath

Publications and source records attributed to U Kunath.

At least 37 records · Page 2Linked to original sources

[Complications and late results following surgical treatment of Echinococcus granulosus].

The case histories of 110 patients with hydatid disease were evaluated for localisation of the cysts, operative treatment and postoperative complications. Pericystectomy and hydatectomy were the most frequently performed operative procedures. 1 of 37 patients, who were followed up, showed a relapse (2.7%). If consideration is taken of the postoperative complications, hydatectomy is a suitable operative procedure for hydatid disease in comparison with pericystectomy.

Adolescent↗

[Morphology of the lower esophagus after endoscopic varicosclerosation (author's transl)].

Submucous injection of 5 p.c. phenol in arachis oil in the lower esophagus can stop a bleeding from esophageal piles without considerable complications. Microscopical examinations on 14 human esophageal specimens demonstrate that phenol in oil as opposed to other sclerosing solutions produces only a mild, bland running inflammation in the tissue. Deep mucosal ulcerations, perforations of the wall, phlegmonous inflammations or mediastinitis could be observed. Nevertheless, under the intact esophageal mucosa a sufficient production of collagen fibres develops, which is effecting a varicosclerosation.

Adult↗

[The effect of cimetidine on oxygen consumption and blood flow in the gastric fundus wall after dissection of the left gastric vessels: an experimental study on pigs (author's transl)].

Determination of the regional gastric blood flow in pigs with tracer microspheres indicates maximum blood flow in the fundus mucosa, even after dissection of the left gastric vessels. Excessive aerobic metabolism in this region was proved by measuring the arteriovenous oxygen difference. Fundus oxygen consumption was significantly depressed by cimetidine; change of blood flow distribution, a disadvantage for the seromuscular fundus layer, was inhibited.

Animals↗

[Indications and results of Y-gastrojejunostomy after gastric resection (author's transl)].

The Y-gastrojejunostomy with a long jejunal loop is advantageous in the treatment of recurrent ulcer after gastric resection and in the treatment of persistent peptic esophageal stricture. The peptic damage of esophageal mucosa by gastric juice and bile is thus prevented, and the stricture can heal. In regard to the pathogenicity of duodenogastric bile reflux, the routine Y-technique in gastric resection seems reasonable.

Adult↗

[Esophagus replacement by an isoperistaltic gastric tube (author's transl)].

In 20 patients the esophagus was replaced by an isoperistaltic gastric tube. Cervical esophagogastrostomy was performed. Postoperatively motility, histology, gastric secretion, and emptying time of the gastric tube were investigated. The esophageal replacement showed residual motility, pyloric motility, atrophic gastritis, decreased basal and stimulated secretion and normal emptying time, except in two patients. There were no essential drawbacks in function of the intrathoracic gastric tube. Patients with esophagectomy are comparable to patients with partial gastrectomy.

Esophagoplasty↗

[Is the duodenal papilla an autonomic sphincter? A contribution to the functional morphology (author's transl)].

A morphologic study of the duodenal papilla was performed by laminations in three planes. The muscle system reveals that there are no autonomic sphincters, but muscle bundles deriving from duodenal longitudinal and circular muscle layers, interdigitating and acting for opening of the papillary mouth. Activity results from myogenous rhythmic contractions of smooth muscle cells, stimulated by the ductal hydrostatic pressure, and from the duodenal peristalsis. The closure of the papilla is weak, incomplete and achieved by the oblique entrance of the duct. Interpretation of functional analysis and procedures of treatment should be based upon the knowledge of normal morphology of the papilla.

Ampulla of Vater↗

[Results and experiences with esophagectomy by blunt dissection].

Esophagectomy by blunt dissection is performed on patients with cervical and distal esophageal carcinoma and with extended carcinoma of the cardia. Further indications are lye strictures and in selected cases recurrent bleeding from esophageal varices. The results are demonstrated of 40 patients who have undergone surgery and the experiences are discussed.

Adenocarcinoma↗

[Blunt dissection of the esophagus].

The operative technique of blunt dissection of the esophagus is described, in which opening the thorax to remove the total esophagus is not necessary. This procedure is indicated in carcinoma of the laryngopharynx and carcinoma of the proximal and distal third, in lye strictures, and scleroderma of the esophagus. Blunt dissection is advantageous because it contains less risk compared to operations with opening of the pleural and abdominal cavities. In malignomas blunt dissection can be more radical than tumor resection. For esophageal replacement we used the stomach, which was transformed into a tube supplied by the right gastric arteries.

Adenocarcinoma↗

[The oxygen tension in the gastric fundus wall in relation to arterial blood supply. Experimental study with intramural pO2-measurement (author's transl)].

Animal experiments in dogs were performed in order to measure oxygen tension in the gastric fundus. For this purpose an intravasal oxygen catheter electrode was inserted into the gastric submucosa. The probe recorded pO2 in an area about 2 cm in length. The oxygen tension was measured in relation to the respective blood supply of stomach. The method is suitable for determining the tendency of oxygen supply of the tissue intraoperatively as well as after implantation postoperatively. The clinical interpretation of the trend of pO2-measurements depends on further experiences.

Animals↗

[Pressure-diameter-relationship of the papilla duodeni. An experimental study (author's transl)].

While extending the papilla duodeni of dogs by probes of increasing diameter, mural pressure was measured as an equilibration of the hydrostatic pressure within the probes along a distance of 12 mm. Pressure-diameter-curves at the duodenal end of the papilla show the mural pressure promptly increasing to a maximum when partially extended, then declining and rising again when extended extremely. Proximal to the papillary end the mural pressure first declines and then continuously increases with larger probe diameters. The pressure-diameter-curve of the papillary end resembles the length-tension-diagram of isolated smooth muscle in vitro, and represents the normal physiological action of the sphincter zone.

Ampulla of Vater↗

Functional analysis of organic sphincter systems by elastance-measurement. Evaluation of a new method.

The function of organic sphincter systems cannot be described by measuring a static pressure, but only by applying a dynamic procedure of measurement that takes into account the characteristics of smooth muscles. Therefore, the elastance-method has been developed. Experiences with this method and its clinical value are demonstrated when one applies this procedure to measurements in the lower oesophagus, the duodenal papilla and the anal canal.

Ampulla of Vater↗

[Functional morphology of the lower esophagus in reflux disease (author's transl)].

The function of the lower esophagus is discussed from a biomechanical point of view. The functional elements consist of the typical structure of the muscle fibers and of the construction of the opening to the stomach. In the active phase, the esophageal muscle fibers open the cardiac orifice, and during the resting stage, the normal longitudinal tension of the esophagus is responsible for closure. Biomechanical studies reveal the sliding hiatal hernia and reflux as momentary states in the pathomechanics of the lower esophagus. Hormonal regulation is unimportant. Based on biomechanical studies, a reasonable therapeutic approach is gastropexy.

Cardia↗

[Recurrent collapse of one lung (author's transl)].

A case of recurrent collapse of one lung is reported. It developed within 90 minutes after reexpansion of a completely collapsed lung induced by pneumothorax. There was no demonstrable cause for the recurrence of the atelectasis. Treatment was by means of a bird respirator (ventilation via a mouthpiece) with respiratory resistance. Factors possibly responsible for the secondary atelectasis are discussed.

Adult↗