Search PubMed⌕ Search

Biomedical subjects

U Krause

Publications and source records attributed to U Krause.

At least 217 records · Page 12Linked to original sources
PubMed1982

[Enlargement surgery of duodenal stenosis caused by chronic pancreatitis with a pedicled open jejunal graft].

A method of enlarging localized duodenal stenosis is described in a case of chronic pancreatitis. After incision of the duodenum in the stenosis area, the defect is closed by an open, vascularized jejunum transplant. This method has several advantages over by-pass procedures. The physiological passage of the ingesta is preserved. Other methods such as a pedicle graft from the stomach or the colon may be functionally equally good, but more dangerous.

Chronic Disease↗
PubMed1981

[Autotransplantation of cryopreserved human parathyroid tissue (author's transl)].

Following the third operation, aparathyroidism occurred in a 70-year-old female with primary hyperparathyroidism due to parathyroid hyperplasia. Part of the parathyroid obtained during the last operation was cryopreserved immediately after resection and replanted successfully after 15 days into the lower arm muscles. The function of the transplanted tissue was demonstrated by successful stepwise reduction of hormone substitution. Parathyroid hormone concentrations in the blood of the veins draining the transplanted tissue were more than double in comparison with the contralateral side. Functional and morphological investigations of the defrosted tissue prior to transplantation showed vitality and intact morphology.

Aged↗
PubMed1981

The effects of equal caloric amounts of xylitol, sucrose and starch on insulin requirements and blood glucose levels in insulin-dependent diabetics.

Xylitol has been suggested as a potentially useful sweetener in the diabetic diet. In 14 insulin-dependent diabetics a standard diabetic diet regimen was compared with diets in which starch was isocalorically exchanged in the breakfast meal by either 30 g xylitol or 30 g sucrose. Insulin requirement and blood glucose were measured using a glucose-controlled insulin infusion system. The results following breakfast with xylitol were similar to those after starch breakfasts. Sucrose, in contrast, induced a greater post-prandial rise in blood glucose levels despite counter-regulation by the glucose-controlled insulin infusion system. Insulin requirement after sucrose significantly exceeded (p less than 0.01) that after xylitol or starch during the first 60 min and 2 h respectively. No short-term side effects of xylitol were found.

Adult↗
PubMed1981

C-peptide-measurement: a simple method for the improvement of specificity.

Sera containing insulin antibodies and proinsulin give artifactual high readings in C-Peptide measurement. This problem can be circumvented by the removal of antibodies and proinsulin prior to C-Peptide assay. A method is described which enables the removal of antibodies and proinsulin from sera without affecting the C-Peptide determination. Furthermore, this method allows a semiquantitative estimation of proinsulin, provided there is enough cross reactivity of the C-Peptide antibody with proinsulin.

Animals↗
PubMed1981

[The effect of enflurane anaesthesia and operation on the sympathoadrenal and adrenocortical system (author's transl)].

The effect of enflurane anaesthesia on the sympathoadrenal system, the hypothalamic-hypophyseal-adrenocortical system, and on the circulatory system was investigated in patients undergoing ophthalmic surgery. Blood concentrations of adrenaline, noradrenaline, ACTH, cortisol, and arterial blood pressure and heart rate were measured in 10 patients 30 min after premedication (I), 3-5 min after surgical incision (II), 20 or 45 min after surgical incision (III) and in 7 of 10 patients 10-15 min after extubation (IV). After conventional induction anaesthesia was maintained with enflurane (1.5-2.0%), combined with N2O/O2 2:1, and intermittent relaxation. Plasma adrenaline, ACTH, cortisol and heart rate increased significantly during operation, while plasma noradrenaline and blood pressure did not change significantly. Thus enflurane anaesthesia could not completely inhibit the increased activity of sympathoadrenal and hypothalamic-hypophyseal-adrenocortical system caused by surgical stress.

Adolescent↗
PubMed1981

Parietal cell vagotomy and truncal vagotomy as treatment of duodenal ulcer. A prospective randomized trial.

In a prospective randomized trial parietal cell vagotomy (PCV) was compared with truncal vagotomy with drainage (TV) in the treatment of duodenal ulcer. The material consists of 106 patients, 50 TV and 56 PCV. Basal and maximal acid output (BAO, MAO) were measured preoperatively, 6 weeks and 12 months postoperatively. The clinical results were judged from a modified Visick grading system 1-6 years postoperatively. BAO 6 weeks after PCV was reduced with 60% in average and 12 months postoperatively with 45%. After TV the BAO was reduced with 53% 6 weeks postoperatively and 34% 12 months postoperatively. MAO was reduced with 47% 6 weeks after PCV and with 31% 12 months postoperatively. After TV the reduction of MAO was 50% and 44%, respectively. After PCV 62% of the patients were insulin positive at the first postoperative examination and 78% one year later. After TV 46% of the patients had a positive insulin test at the first postoperative examination and 50% one year later. In the PCV group 9 patients (16%) have got recurrences during the 1-6 years observation time, in the TV group there were 4 recurrences (8%). In the PCV group 24% of the patients with pyloric or prepyloric ulcer got recurrences and 13% of the patients with duodenal ulcer. In the TV group the number of recurrences was 13% and 6%, respectively. At the modified Visick classification 71% of the patients in the PCV group were graded as I and II, 4% as III and 25% graded as IV. After TV 83% of the patients were graded as I and II, 4% as III and 13% graded as IV. The results from this study do not allow us to recommend PCV before TV and it should be seriously questioned if it shall at all be performed on prepyloric ulcers.

Adult↗
PubMed1980

[Glucose assimilation, insulin secretion and insulin sensititivy in psoriasis patients].

The discussion about a connection between diabetes and psoriasis is picked up again. Serum-values of glucose, insulin and C-peptide after intravenous glucose-load and of glucose and C-peptide after intravenous insulin-load were tested. The level of insulin and C-peptide after i. v. glucose-load was found higher in psoriasis-patients (hyperinsulinism). Considering earlier investigations and new results in diabetes-research (incretin concept), a connection between the two diseases must be denied. The carbohydratemetabolism-deviation in psoriasis could be declared by an enteropathy.

C-Peptide↗
PubMed1980

[Cryopreservation of human parathyroid tissue (author's transl)].

Cryopreservation of human parathyroid tissue achieved significance through the introduction of autologous transplantation in parathyroid surgery. The technique of cryopreservation and thawing is described. The functional integrity of frozen tissue was examined by checking its calcium-sensitivity which was compared with that of fresh tissue. This demonstrated a similar secretion pattern. Examination of the frozen tissue under the light and electronmicroscope showed almost all of the cells to be preserved. The indication for cryopreservation is given at total parathyroidectomy and autologous transplantation at primary and secondary hyperplasia, as well as at reintervention in primary hyperparathyroidism or in total thyroidectomy where it is not certain that living parathyroid tissue was left in situ.

Adenoma↗
PubMed1980

Glucagon secretion in four duodenopancreatectomized patients after arginine and glucose load.

It is well established that in sera of totally duodenopancreatectomized dogs after complete insulin deprivation an immunoreactive glucagon can be found, which is indistinguishable from the pancreatic glucagon, and which can be stimulated by oral glucose and i.v. arginine as well. In four duodenopancreatectomized patients we found, after 26 h insulin deprivation, normal and elevated basal levels of IRG which were not stimulated by intravenous arginine but by oral glucose. Dilution tests of the sera before glucose stimulation showed immunological properties different from pancreatic standard glucagon, whereas in sera after stimulation immunoidentity with pancreatic standard glucagon could be demonstrated. Gel chromatography of the sera after stimulation yielded at least three immunoreactive peaks, the first over 30 000 daltons, a second eluting in the region of insulin, and a third of about 2000 daltons. True glucagon (3500 MW) could not be clearly demonstrated.

Adult↗
PubMed1980

Histopathology of clinically successful intraocular lens implant.

A 50-year-old man had an intracapsular cataract extraction with placement of a Worst medallion iris-supported lens. After 6 days postoperatively the eye appeared quiet, the cornea was clear and the implant in place. The patient died 17 days postoperatively of subarachnoid haemorrhage. Histopathological examination revealed slight loss of endothelial cells in the upper corneal region, pressure atrophy without signs of repair of the iris stroma, loss of pigment epithelial cells of the iris in places as well as local pigment epithelial cell proliferations. The chamber angle was open and the anterior uvea revealed only a minimal inflammatory cell reaction. The unoperated opposite eye showed cortical cataract as well as advanced hypertensive retinopathy.

Atrophy↗
PubMed1980

Endotoxin-induced microclots in ulcerative colitis and Crohn's disease.

Radially oriented fibrin microclots were observed when blood from patients with active lesions of Crohn's disease and ulcerative colitis was kept in capillary tubes for 24 h. Addition of bacterial extract or endotoxins increased the fibrin formation. The phenomenon is not seen in healthy subjects or patients who have healed after colectomy. The data are consistent with our findings in patients with vasculitis and support the view that patients with Crohn's disease and ulcerative colitis have circulatory endotoxins.

Adolescent↗
PubMed1980

Treatment of delayed puberty by intranasal application of gonadotropin-releasing hormone (GnRH).

Seven male patients between 15(5)/12 and 19(6)/12 years of age with delayed puberty, two of them anosmic, received 200 microgram GnRH nasally (N) six to eight times daily for a period of 3 months, or in one case for 6 months. Changes in basal secretion and responsiveness of the gonadotropins were recorded by serial GnRH tests. Serial measurements of serum testosterone (T) were also done. While serum T, before treatment, was low it prepubertal levels in all patients, basal serum gonadotropins and gonadotropin responsiveness in the GnRH tests were found to be within the adult range in most of the patients. In the two anosmic patients, after 2 to 4 weeks of treatment decreasing gonadotropin responsiveness of GnRH was observed, and no, or only transitory, increases of serum T were found. In another patient, in spite of sustained gonadotropin responsiveness of GnRH throughout the treatment, no increase of serum T was seen which is probably due to additional primary Leydig cell deficiency. In the other four patients increases of serum T were observed which, however, did not reach the middle of the normal adult range. If stimulation of T secretion was achieved a further increase of serum T was observed after termination of the treatment. Thereafter, serum T returned to pretreatment values in one patient or stayed within the normal adult range in two other patients. No significant effects on clinical parameters were found with the GnRH therapy. This is probably due to the short duration of therapy in these patients as well as to the changes in serum T observed during the treatment, which are small in comparison to gonadotropin therapy.

Administration, Intranasal↗
PubMed1980

[Bone metastases of prostatic cancer in relation to tumor size and grade of malignancy (author's transl)].

In 153 patients with prostatic cancer total body bone scintigraphy was performed. Forty six patients showed bone metastases while there was no evidence of skeletal involvement in 101 cases. Our results show that the tendency of bone metastases increases when low differentiated type of malignancy is present: Patients with low grade malignancy (G1) showed bone metastases in 7.3%, with middle grade malignancy (G2) in 40%, and with high grade malignancy (G3) in 38.5%. We were also able to establish a correlation between tumor size and frequency of bone metastases: Patients with tumor size T1 showed bone metastase in 7.1%, with tumor size T2 in 19.3%, with tumor size T3 in 39.2%, and with tumor size T4 in 65%. Furthermore, we found that the incidence of low differentiated tumors appeared to be more common in increased tumor size. These results show the value of early detection of prostatic cancer.

Aged↗