Biomedical subjects
Publications and source records attributed to U Kaboth.
Lowered, normal or raised alpha1-antitrypsin levels were found in 81 patients with acute or chronic relapsing pancreatitis and pancreatic carcinoma. 51 patients with chronic pancreatitis did not have alpha1-antitrypsin deficiency. Thus, in contrast to other reports, alpha1-antitrypsin deficiency and chronic pancreatitis do not seem to be in common association.
In contrast to the situation in disseminated lupus erythematodes, in pseudo-LE syndrome the serum-complement factors C'3 and C'4 are elevated and not decreased in the active stage of the disease. Although both diseases are defined and easily distinguished by the demonstration of the specific pathognomonic autoantibodies, at least in the active stage, they can also be distinguished by determining these two complement factors. The finding also demonstrates a different pathogenesis of the two diseases. The serum concentration of C'3 activator is elevated both in LE and pseudo-LE. In the former, determining C'4 is a more sensitive test than that of C'3.
Serial biopsies were taken over four to five years from 15 healthy hepatitis-Bs antigen-positive persons with normal biochemical findings ("healthy carriers"). The antigen persisted throughout, but the histological picture did not worsen in any way: there was certainly no sign of chronic progressive liver disease.
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Monomeric IgM could be found rather frequently in acute hepatitis and chronic aggressive hepatitis and occasionally also in chronic persistent hepatitis. Earlier it was reported in lympho-proliferative-, autoimmune diseases, some infectious diseases and in cirrhosis of the liver. The occurence of monomeric IgM in chronic aggressive hepatitis correlates with the detection of several autoantibodies (ANA, SMA, RF). The 7S-IgM-test may be used as an easily measurable additional criterium for diagnosis and course of chronic liver diseases.
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