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Biomedical subjects

U Datta

Publications and source records attributed to U Datta.

60 records · Page 4Linked to original sources
PubMedDate not supplied

Genetic correlation in otosclerosis.

PURPOSE: The aim of this study was to determine the relationship of HLA typing in patients with otosclerosis. MATERIALS AND METHODS: We used a prospective study in which HLA typing of 100 surgically confirmed otosclerosis patients were compared with age and sex matched normal individuals. RESULTS: HLA-A3, HLA-A9, HLA-A11, and HLA-B13 were found to be significantly higher (P < .05, .01, and .01, respectively). HLA-A9 and HLA-A11 were found to be higher (P < .01) in patients with a positive family history, indicating genetic heterogenicity. CONCLUSIONS: Higher values of HLA-A9, HLA-11, and HLA-B13 in patients with otosclerosis compared with normal individuals strongly suggests a genetic, HLA-related component.

Adolescent↗
PubMedDate not supplied

Pleural effusions in non-Hodgkin's lymphoma. A cytomorphologic, cytochemical and immunologic study.

Review of the records of 243 cases of cytologically diagnosed non-Hodgkin's lymphomas (NHL) revealed pleural effusions in 21 (8.6%). Cytologic examination of pleural fluid was done in 17 cases, of which 16 were reported as positive. Cytologic examination was supplemented with cytochemical staining (acid phosphatase, alpha naphthyl acetate esterase and periodic-acid-Schiff reactions) and E-rosetting studies in 12 cases. Of the 16 positive cases, 11 were malignant lymphomas consisting of convoluted lymphocytes. Acute lymphatic leukemia of the prothymocytic type (T-ALL) and chronic lymphocytic leukemia of the T-cell type (T-CLL) comprised one case each, and there were three cases of follicular center cell lymphomas, two of the cleaved-cell type and one of the Burkitt-type. Comparison of the cytomorphology of the tumor cells in the pleural effusion with those in fine needle aspiration smears from the solid tumors in 14 cases showed an identical appearance in 13 cases; in one, the Burkitt-type lymphoma, the cells were larger and more pleomorphic in the pleural effusion. This study indicates that the cytologic diagnosis and categorization of NHL of the convoluted-cell type is greatly enhanced by the study of neoplastic lymphocytes in a pleural effusion.

Adolescent↗
PubMedDate not supplied

The influence of lactation on L-proline absorption from small intestine in the albino rat.

Intestinal absorption of L-proline was studied in control and lactating rats from jejunum and ileum by in vivo method and presented per unit dry weight and per unit length of the respective segment. L-proline absorption was found to be significantly reduced in lactating animals as compared to the virgin controls. The results were discussed in light of serosal to mucosal ratio. By in vitro method also jejunal and ileal uptake of L-proline were found to be significantly reduced in lactating animals as compared to the virgin controls.

Animals↗