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Biomedical subjects

U Butturini

Publications and source records attributed to U Butturini.

At least 55 records · Page 3Linked to original sources
PubMed1983

Evidence that basal beta cell activity may play a role in determining insulin sensitivity in healthy man.

Aim of this investigation was to correlate basal beta cell function and insulin sensitivity in healthy man. A group of 10 healthy subjects with normal body weight and glucose tolerance was studied. Insulin sensitivity was assessed by glucose disappearance rate after insulin injection (0.1 IU/kg body weight). Beta cell secretion rate was estimated by the evaluating of fasting C peptide circulating levels. A positive and significant relationship was observed between fasting C peptide concentrations and coefficients of insulin sensitivity (r = 0.694, p less than 0.05). We conclude that in healthy man basal beta cell secretion rate plays an important role in determining the peripheral sensitivity to insulin. In particular, hormone sensitivity is directly proportional to pancreatic hormone production in basal condition.

Adult↗
PubMed1983

Absolute bioavailability of ceftriaxone after intramuscular administration to healthy volunteers.

The disposition and bioavailability of ceftriaxone, a novel cephalosporin, was studied in 7 healthy volunteers after a single 1.5-gram intramuscular administration in comparison with the same dose given by the intravenous route. The plasma levels were measured by means of a high-performance liquid chromatography method up to 48 h after administration. Comparable areas under plasma concentration-time curve (AUC) and biological half-life were obtained proving that ceftriaxone, if assessed by conventional methods, is completely bioavailable when given by the intramuscular route. However, taking into account its nonlinear pharmacokinetics it becomes obvious that direct comparison of AUC values generally leads to a certain overestimation of bioavailability after extravascular administration. This aspect is briefly discussed.

Adult↗
PubMed1982

Nonspecific growth hormone responses to thyrotropin-releasing hormone in insulin-dependent diabetes: sex- and age-related pituitary responsiveness.

To evaluate GH pituitary responsivity to nonphysiological stimuli in insulin-dependent (type I) diabetes, a TRH test (200-micrograms iv bolus) was carried out in 31 type I diabetics (16 females and 15 males). TRH was capable of inducing GH responses in most of the studied patients, with a striking difference between the sexes; responses were documented in 7 of 15 males and in 13 of 16 females. Linear regression analyses of the results showed a positive correlation between basal values and peak levels of GH and a negative correlation between GH peaks and the ages of the patients. No correlation was found between GH values (basal and peak levels) and blood glucose levels or duration of disease. In conclusion, our results support the observation that GH secretion in diabetes is abnormal. TRH induces GH secretory responses, especially when GH basal values are elevated and in female patients. Pituitary GH responsiveness to TRH shows a progressive decline with advancing age unrelated to the duration of the disease or the presence of retinopathy.

Adolescent↗
PubMed1982

Vitamins E and A in vascular diseases.

The major pathogenetic factors of the atherosclerotic diseases are: a) vasal endothelium distress; b) rheological disturbs; c) alterations in plasma lipid pattern; d) dietary intake of saturated and polyunsaturated fatty acids; e) alteration of mitochondrial and microsomal membranes; f) vascular injury induced by immune complexes; g) increased lipid peroxidations. Many well documented reports state a positive effect of vitamins A and E on some of the factors previously considered. Vitamins A and E have an endothelium-protective activity and an antiperoxidative effect; they act as antiaggregant factors, affect O2 transport and utilization processes, increase HDL-cholesterol, potentiate the hypolipidemic action of the nicotinic acid.

Arteriosclerosis↗
PubMed1982

The effect of pyridoxine-alpha-ketoglutarate (PAK) on exercise-induced increase of blood lactate in patients with type I diabetes.

Administration of pyridoxine-alpha-ketoglutarate (PAK) to a group of insulin-independent non-ketotic diabetics decreased (p less than 0.01) the plasma concentration of lactate response to isometric exercise. The mechanism of action of PAK could be interpreted as a consequence of changes induced by the drug on the Krebs' cycle with a subsequent reduction of lactate production.

Adolescent↗
PubMed1981

[Urinary levels of dehydroepiandrosterone in a group of male patients with functional hyperprolactinemia].

On 22 male patients diagnosed as "functional hyperprolactinemia" (the Prolactin (PRL) basal value, was higher than the basal PRL means +/- 2 DS of a control group) we have measured the urinary excretion of Dehydroepiandrosterone (DHEA) mainly produced by adrenal cortex. Our results haven't shown no difference in the urinary excretion of DHEA values in hyperprolactinemic patients has been documented.

Adult↗