Biomedical subjects

U Bosch

Publications and source records attributed to U Bosch.

At least 73 records · Page 4Linked to original sources

PubMed1996

[Morphologic aspects of alloplastic augmentation in replacement of the posterior cruciate ligament. An experimental study on the sheep].

The treatment of injuries to the posterior cruciate ligament (PCL) remains controversial. Various problems have prevented PCL reconstruction from consistently producing the knee stability desired. Biological graft tissue undergoes a remarkable healing process comprising different phases. The strength of autogenous graft material decreases soon after the operation. During this early healing phase synthetic augmentation could protect the graft tissue from overloading or overstretching, supporting the tissue restoration process. In order to evaluate the morphological effects of the ligament augmentation device (LAD) on a free patellar tendon autograft in PCL reconstruction a comparative study in sheep was conducted. In 24 mature sheep the PCL was replaced with either a patellar tendon autograft alone or a patellar tendon autograft augmented by the LAD. The LAD was fixed at both ends. The animals were not immobilized after the operation. Tibial fixation was released 8 weeks after the operation. The autografts of both groups were histologically evaluated after 2, 6, 16, 26, 52 and 104 weeks. In addition to necrotic and degenerative alterations a pronounced inflammatory reaction could be seen in the LAD-augmented autografts soon after the operation. Compared with the non-augmented autograft, tissue formation and remodeling was delayed in the augmented group. After 1 and 2 years, the morphology of the autograft tissue was similar in the augmented and the non-augmented group and was different from that of a normal PCL. The LAD was surrounded by a chronic inflammatory reaction, and collagen fiber ingrowth into the LAD was not observed. Transmission electron microscopy showed that small-diameter collagen fibrils were predominant in the graft tissue of both groups. Thus, better remodeling of the autograft tissue in the presence of the LAD was not demonstrable in this particular study. The value of synthetic augmentation of biological grafts of PCL reconstruction seems to be questionable at present.

Animals↗

PubMed1996

[Surgical treatment of acute, complete acromioclavicular joint dislocation. Indications, technique and results].

From June 1983 to May 1990, 51 patients were operated on for acute, complete acromioclavicular dislocation (Tossy III). The operative technique includes suturing of the coracoclavicular and acromioclavicular ligaments and stabilization of the clavicle with resorbable, 10-mm coracoclavicular PDS banding. Six patients received primary resection of the lateral end of the clavicle due to significant injury of the AC joint cartilage. Forty-two patients with an average follow-up of 6.1 years were evaluated clinically using the UCLA and Constant-Murley Score, as well as subjective grading. Additional radiological assessment was performed in 36 cases. Excellent or good clinical results were obtained in 97.6%, with 85.7% being free of pain. All patients with primary resection of the lateral end of the clavicle had no pain. The incidence of postoperative complications was low (one deep wound infection with removal of the PDS band, three secondary dislocations). Post-traumatic arthritis developed in 14.7% of the patients. In those cases of acute grade III AC joint dislocations where operative treatment is indicated, this technique provides excellent results with a low complication rate.

Acromioclavicular Joint↗

PubMed1995

Collagen fibril diameter distribution in patellar tendon autografts after posterior cruciate ligament reconstruction in sheep: changes over time.

The alterations in collagen fibril diameter distribution, mean fibril diameter and the area occupied by collagen after posterior cruciate ligament reconstruction using a patellar tendon autograft were estimated 2, 6, 16, 26, 52 and 104 wk postoperatively. Patellar tendons and posterior cruciate ligaments from unoperated animals were used as control tissues. Collagen fibrils were divided into histograms according to their diameter in order to analyse distribution maxima. There was a significant decrease in mean fibril diameter of the grafts in comparison with the control tissues. At 104 wk it was only about 51% of that for control posterior cruciate ligaments. The total area occupied by collagen was significantly reduced at 6 wk postoperatively and was about 57% in comparison with normal posterior cruciate ligaments. A considerable increase of small diameter collagen fibrils together with a loss of large fibrils was responsible for these results. There was no evidence of reestablishment of large diameter fibrils, which are normally found in tendon and ligaments, up to 2 y after transplantation. The total area covered by collagen was still reduced at this stage although the number of fibrils had increased.

Animals↗

PubMed1995

[Rockwood capsulorrhaphy in shoulder instability. A clinical follow-up study].

Rockwood described a capsulorrhaphy technique for operative treatment of multidirectional shoulder instability with anterior dislocation. We have used this technique mainly in patients with severe multidirectional instability and now have 8 years' experience with it, which is reported below. The surgical technique involves refixation of the Bankart lesion with transosseous suture and double breasting of the anterior capsule. No transposition of the subcapularis muscle was performed. A functional rehabilitation program without immobilization was used in all patients. The daily activity level, the degree of discomfort upon shoulder-related activities and the subjective assessment of outcome were recorded for each patient. General outcome was determined with reference to Rowe's score. A clinical examination was performed as well as radiography. Strength was evaluated by standardized bilateral dynamometry. Follow-up examination was possible in 73 out of 82 patients. The mean age at follow up was 32.7 +/- 4.1 years, and the mean follow-up time, 4.3 years. The reason for surgery was recurrent dislocation in 81% of patients, pain in 4% and both pain and dislocation in 15% of patients. In 8 patients (10.9%) multiple (up to 4) previous surgical attempts by various methods had been unsuccessful. Postoperatively 59% (n = 44) were able to take part in sports without restrictions, 27.4% could take part only in sports not involving the shoulder, and 13.5% (n = 10) did not engage in any sports postoperatively. The redislocation rate was 12.3% (n = 9), and there was 1 traumatic redislocation. A deficit in abduction/elevation by 10-60 degrees was found in 4 patients (5.4%) and by > 60 degrees in 2 patients (2.7%).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed1994

Changes in the extracellular matrix of the autogenous patellar tendon graft after posterior cruciate ligament reconstruction: a biochemical study in sheep.

The left knee joints of female German sheep were operated, replacing the posterior cruciate ligament by the central third of the patellar tendon. After 2, 6, 16, 26 and 52 weeks the graft of the operated leg as well as the contralateral central third of the patellar tendon and the posterior cruciate ligament were dissected and used for biochemical analysis. The total glycosaminoglycan content in grafts increases within the first year up to 5 fold and is higher than that of the patellar tendon, but is lower than that of the cruciate ligament. The distribution pattern of glycosaminoglycans differ in the posterior cruciate ligament and the patellar tendon. In cruciate ligament the main components are chondroitin sulfate (76%) and hyaluronan (15%). In the patellar tendon a higher portion of dermatan sulfate (approx. 16%) was found, next to 52% chondroitin sulfate and 22% hyaluronan. During the examination time the grafts show changes in the concentration and the distribution pattern of glycosaminoglycans. The chondroitin sulfate content increases during the experimental period from 1.4 +/- 1.2 mumol/g dry weight (d.w.) to 8.7 +/- 2.9 mumol/g d.w. After 1 year the chondroitin sulfate content in the graft does not differ significantly from that of the cruciate ligament. In the grafts the concentration of chondroitin (non sulfated) increases after 6 weeks up to 1.3 +/- 0.6 mumol/g d.w. in comparison to the value after 2 weeks (0.2 +/- 0.1 mumol/g d.w.) and also in the other groups (16, 26 and 52 weeks) it remains significantly increased. After 1 year the dermatan sulfate content in the graft has increased up to the fifth-fold compared to the value after 2 weeks and is higher than in the patellar tendon and in the cruciate ligament. In graft the hyaluronan content (1.0 +/- 0.4 mumol/g d.w. does not differ significantly in the groups 2, 6, 16, 26 and 52 weeks after operation, but in all five groups it is lower than in the cruciate ligament (2.4 +/- 1.0 mumol/g d.w.). Dermatan and heparan sulfate are not or only little detected in all three tissues. The distribution pattern of glycosaminoglycans in graft shows chondroitin sulfate and dermatan sulfate being the major parts of glycosaminoglycans with a slight increase of these components in the different groups during the experimental period. Hyaluronan makes up to 24 +/- 5% of the whole content of glycosaminoglycans after 2 weeks and decrease to 8 +/- 1% after 52 weeks.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗

PubMed1994

Histochemical aspects of the proteoglycans of patellar tendon autografts used to replace the posterior cruciate ligament.

In the female German black-faced sheep the posterior cruciate ligament was replaced by a free patellar tendon autograft and after 2, 6, 16, 26 and 52 weeks tissue samples of the graft's center (axial region far from bones) were removed for histochemistry and electron microscopy. To localize the proteoglycans Alcian Blue and 0.3 M MgCl2 were added to the fixative solution. The distribution of the proteoglycans in the graft was compared to that of a normal patellar tendon and of a normal posterior cruciate ligament. In the patellar tendon spindle-shaped cells predominated and proteoglycans appeared as short filaments at regular intervals between the collagen fibrils. In the posterior cruciate ligament chondroid cells and long filaments in a net-work-like arrangement were seen. In the patellar tendon autografts short interfibrillar filaments prevailed after 2, 6 and 16 weeks. After 26 weeks and particularly after 52 weeks long filaments also appeared. Digestion with Chondroitinase ABC, AC and Hyaluronidase suggested that the short filaments were PGs containing dermatan sulfate. In grafts, in the early phases the fibroblasts predominated, while in the late phases mainly chondroid cells were observed. The grafts showed aspects of the normal posterior cruciate ligament. However, differences remained, for example the thin collagen fibrils, which could represent one of the reasons for a secondary graft failure.

Actin Cytoskeleton↗

PubMed1994

The Hannover experience in management of pelvic fractures.

Between 1972 and 1993, 1899 patients with fractures of the pelvis were treated at the authors institution. The pelvic ring was fractured in 1479 patients, and 1029 sustained polytrauma. A retrospective study included four parts: (1) Demographic analysis of 1409 patients showed an increase in the severity of pelvic and general trauma during this period. The 17.7% mortality rate was predicted by the Hannover Polytrauma Score and associated extrapelvic blunt trauma. (2) Residual displacement after operative treatment of the pelvis was analyzed in 221 patients. In C type (Tile) fractures residual displacement correlated with external fixation and solely anterior stabilization. (3) Outcome after operative treatment was analyzed in a consecutive series of 58 patients an average of 2.2 years after trauma. Pelvic pain was frequent (Type B 11%, Type C 66%) and correlated with posterior displacement over 5 mm and primary neurological injuries. (4) Mortality after complex pelvic trauma (pelvic fracture with soft tissue injury) decreased from 48.1% to 29.6% during these years. Standardized protocols for primary care and operative procedures of pelvic injuries optimize therapy. Complex pelvic trauma requires early, aggressive surgical management with surgical hemostasis. Further developments in open reduction and internal fixation of the pelvis focus on minimizing additional soft tissue trauma and implants.

Adolescent↗

PubMed1994

The patellar tendon graft for PCL reconstruction. Morphological aspects in a sheep model.

Surgical reconstruction of the PCL has not yet gained the acceptance that ACL reconstruction has achieved. However, in selecting an autograft to restore PCL function in symptomatic posterior knee instability, the free patellar tendon autograft is commonly used at present. Knowledge of the basics in graft healing and of factors regulating this healing process are still limited. It is of interest to determine the biologic response and final morphology of a patellar tendon autograft after PCL replacement. Based on morphological studies in PCL replacement in a sheep model the patellar tendon autograft under-goes necrosis and degeneration followed by a gradual healing process comprising revitalization (i.e. revascularization and cellular proliferation), formation of extracellular matrix components and remodeling. The autograft bone pegs become osseointegrated by 6 weeks. After 2 years, the autograft tissue differs structurally from a ligament, suggesting that the autograft may never approach normal ligament characteristics. Degenerative alterations in the core region of the autograft, the widespread presence of type III collagen and fibronectin, as well as the predominance of thin collagen fibrils do not favor a ligamentization process. The understanding of the autograft healing process remains the prerequisite for a realistic assessment of the biologic PCL replacement and will be a baseline of studies with the goal of influencing the healing process and thus improving the clinical results.

Animals↗

PubMed1994

[Scores as decision aids].

Scoring systems are nowadays said to be helpful in decision-making in preclinical and early clinical treatment of multiple trauma patients. To evaluate the importance of these scores in daily routine, we analysed the scores routinely used in our department at the Hannover Medical School. We present three scoring systems: the Polytrauma Score, the Pelvis Score, and the Hannover Fracture Scale. All of these have certain qualities relevant to the aspects of decision-making and prognostic value. The evaluation demonstrates that these scoring systems are genuinely helpful, especially for the inexperienced.

Adult↗

PubMed1993

[The healing process after cruciate ligament repair in the sheep model].

The patellar tendon autograft is widely used in cruciate ligament replacement. Knowledge of the basic processes involved in graft healing and of factors regulating the healing process is still limited. The patellar tendon and cruciate ligament are morphologically and biochemically distinct, which reflects the different mechanical forces acting on them. Based on morphological studies in posterior cruciate ligament replacement in a sheep model, the patellar tendon autograft undergoes a remarkable transformation process during healing. Distinct healing phases similar to those in would healing can be differentiated. During the phase of necrosis and degeneration the graft tissue becomes disorganized and mechanically weak. During the following phase of revitalization, which is characterized by revascularization, cellular proliferation and formation of collagen and other components of the extracellular matrix, the mechanical properties gradually improve. Even after the phase of remodeling the autograft tissue differs structurally and mechanically from a ligament, suggesting that the autograft only heals to a scar-like replacement tissue. The lack of a fascicular structure, the widespread presence of type III collagen and fibronectin, and the predominance of thin collagen fibrils correlate with a maximum stress of 60% and an elastic modulus of 70% compared with control values. In the sheep model cartilage alterations in the treated knees are similar to those in controls even though reconstruction of the posterior cruciate ligament cannot restore joint stability of controls.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed1993

Staging of patellar tendon autograft healing after posterior cruciate ligament reconstruction. A biomechanical and histological study in a sheep model.

The prerequisite for adequate rehabilitation after cruciate ligament reconstruction with a patellar tendon autograft is a thorough knowledge of the biologic healing processes. It is of interest to determine whether distinct phases similar to those in wound healing can be differentiated. It is also important to assess the magnitude of the biomechanical loading capacity and the duration of the healing processes. One posterior cruciate ligament in each of 48 skeletally mature sheep was replaced with a free patellar tendon autograft. Immediate rehabilitation without immobilization followed. Four phases of healing were demonstrated using the histologic condition of the autograft as a guide. The biomechanical data were correlated with the morphologic data. During the necrotic phase, a maximum of necrotic tissue was seen two weeks postoperatively. The strength of the graft is initially limited by the surgical fixation strength; however, later the intraarticular portion becomes the strength-limiting factor. During the revitalization phase, which is characterized by revascularization and proliferation of fibroblasts, and during the following phase, collagen formation, an increase in maximum stress is seen while the elastic modulus remains constant. Only in the remodeling phase is an increase in elastic modulus seen, owing to longitudinal alignment of the collagen bundles. One year after implantation, the autograft achieves approximately 50% of the material properties of the control. Even after two years, the autograft reaches only a maximum stress of 60% and an elastic modulus of 70% of the control. Ligamentization of the autograft could not be demonstrated in this study, but degeneration was seen in the core region of the graft during late remodeling.

Animals↗

PubMed1992

The pelvic compartment syndrome.

In the pelvic region three major compartments (gluteus medius-minimus compartment, gluteus maximus compartment, and iliopsoas compartment) can be distinguished from the smaller compartment of the tensor fasciae latae muscle. Pelvic compartment syndromes are rare. A clear history of trauma is often lacking. Association with drug and alcohol abuse is common, as is the association with the widespread use of anticoagulant therapy. From 1982 to 1990 six patients with acute buttock compartment syndrome were treated in the Department of Trauma Surgery of Hannover Medical School. In five patients fasciotomy of the gluteal compartment was performed. Two patients with a compartment syndrome secondary to necrotizing fasciitis died of septic multiple organ failure. The mean follow-up of the four other patients was 29 months (7-48 months). Three of these four patients revealed a decrease of gluteal muscle volume. Ergometric tests showed a decrease in gluteal muscle force in all patients.

Adolescent↗

PubMed1992

The relationship of mechanical properties to morphology in patellar tendon autografts after posterior cruciate ligament replacement in sheep.

In a sheep model the posterior cruciate ligament (PCL) was replaced by a patellar tendon autograft (PTAG) using the central one-third of the ipsilateral patellar tendon (PT). The sheep were sacrificed at 16, 26, 52 and 104 weeks postoperation. The PTAG, and, as controls, the contralateral PCL and PT were harvested. These were examined using biomechanical testing as well as light and transmission electron microscopy, including immunohistological techniques. The material properties (maximum stress, elastic modulus) were compared to the morphological features. The cellular distribution, the distribution of glycosaminoglycans (GAGs), the collagen fibril diameter and the occurrence of Type III collagen were studied. Prior to transplantation, the PTAG was shown to be superior in maximum stress (57.2 +/- 5.5 MPa vs 41.3 +/- 1.9 MPa) and elastic modulus (368.8 +/- 49.3 MPa vs 172.3 +/- 14.6 MPa) to the PCL. The early decline in material properties of the PTAG (maximum stress 22% and elastic modulus 42% of the control) after free grafting paralleled a cell- and capillary-rich PTAG tissue with remnants of necrosis and a poorly organized extracellular matrix. Two years after implantation, with progressive alignment of the tissue matrix, maximum stress and elastic modulus acquired approximately 60 and 70% of the control, respectively. However, there was also an evidence of degenerative changes characterized by acellular areas, loss of the normal bundling pattern of collagen fibers and abnormal accumulation of GAGs. Ultrastructurally, there was a predominant shift to thin collagen fibrils in the PTAG compared to PCL and PT, both consisting of thick and thin collagen fibrils. Thin fibrils were demonstrated to be, in part, split thick fibrils as well as newly formed fibrils. Most of these thin fibrils revealed a positive reaction with antibodies to Type III collagen.

Animals↗

PubMed1992

Toxin production by Fusarium species from sugar beets and natural occurrence of zearalenone in beets and beet fibers.

Fifty-five Fusarium isolates belonging to nine species were collected from fungus-invaded tissue of stored sugar beets and identified as F. acuminatum (11 isolates), F. avenaceum (1 isolate), F. culmorum (1 isolate), F. equiseti (23 isolates), F. graminearum (4 isolates), F. oxysporum (1 isolate), F. solani (4 isolates), F. sporotrichioides (7 isolates), and F. subglutinans (2 isolates). All isolates were cultured on autoclaved rice grains and assayed for toxicity by feeding weanling female rats the ground-rice cultures of the isolates in a 50% mixture with a regular diet for 5 days. Fifty-eight percent of the isolates were acutely toxic to rats, 26% caused hematuria, 18% caused hemorrhages, and 29% caused uterine enlargement. In most cases, toxicity could not be accounted for by the known toxins found. The following mycotoxins were found in extracts of the rice cultures: zearalenone (22 to 6,282 micrograms/g), chlamydosporol (HM-8) (68 to 4,708 micrograms/g), moniliformin (45 to 400 micrograms/g), deoxynivalenol (10 to 34 micrograms/g), 15-acetyldeoxynivalenol (5 to 10 micrograms/g), diacetoxyscirpenol (22 to 63 micrograms/g), monoacetoxyscirpenol (21 to 26 micrograms/g), scirpenetriol (24 micrograms/g), T-2 toxin (4 to 425 micrograms/g), HT-2 toxin (2 to 284 micrograms/g), neosolaniol (2 to 250 micrograms/g), and T-2 tetraol (4 to 12 micrograms/g). F. equiseti was the predominant species found on visibly molded beets in the field. Six of 25 moldy sugar beet root samples collected in the field contained zearalenone in concentrations ranging between 12 and 391 ng/g, whereas 10 samples from commercial stockpiles were negative for zearalenone.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed1992

[Standardized osteosynthesis techniques for the pelvic ring. Analysis of a patient sample and surgical technique].

A total of 1566 patients with fractures of the pelvis were treated at the Department of Traumatology at the Hannover Medical School between 1972 and 1990. Of these, 1350 patients had fractures of the pelvic ring, 216 isolated acetabulum fractures, and 398 combinations of pelvic ring fractures and acetabular involvement. Of these patients, 718 were admitted with severe polytrauma. For 1254 patients complete files were available for clinical and radiological evaluation of fracture distribution, classification (Tile and anatomical location) and concomitant injuries. A significant increase in the severity of trauma, the severity of the pelvic fractures and the rate of internal stabilization, especially of the posterior pelvic ring, was observed during the observation period. The overall mortality after pelvic fracture was 18.1%. This mortality was correlated to the Hannover Polytrauma Score (PTS) and the associated extrapelvic blunt trauma. Internal fixation of pelvic fractures was performed in 195 patients. Our experience led to standardized procedures for the different fracture locations. In fractures type Tile B, an anterior procedure led in all cases to anatomic or near anatomic healing. In unstable pelvic ring fractures (Tile C), external fixation led to a significantly higher rate of posterior dislocations (over 1 cm) than did internal fixation. In these situations a combined posterior and anterior internal fixation procedure improved the result compared to posterior internal stabilizations alone. As a result, internal stabilization using a standardized technique for every fracture location is recommended for all unstable pelvic ring fractures.

Adolescent↗

PubMed1992

[Primary management of pelvic injuries].

High energy fractures of the pelvis are often associated with genitourinary, neurological, vascular, intestinal, and other skeletal injuries. The pelvic fracture therefore reflects only some of the destructive energy sustained by the patient and is a marker for the associated soft tissue injuries. In these complex pelvic injuries assessment, stabilization, and definitive treatment are complicated. The mortality of complex pelvic injuries is high. Uncontrolled bleeding and septic complications are the main causes of death. The presence of the associated injuries necessitates thorough evaluation in every case. The goals of treatment are prevention of early death from hemorrhage, early detection and treatment of all concomitant injuries, and restoration of the patient to the preinjury level of function. At the scene of the accident, problems affecting the airway, breathing, and circulation should be dealt with first. For prehospital immobilization and transportation of the patient a beanbag should be used. With the aim of improving primary hospital treatment of patients with complex pelvic injuries, a trauma algorithm is presented. This provides for decisive therapeutic steps after brief clinical, radiologic and ultrasonographical assessments. The major questions in the flow chart take the pelvic ring and hemodynamic instability into account. Immediate laparotomy, surgical control of hemorrhage, and open reduction and internal fixation of an unstable pelvic ring are the most important requirements for successful treatment. From 1972 to 1990 the clinical course and outcome of 132 patients with complex pelvic injuries were reviewed. The overall mortality was 34.8%. As the changes in the treatment protocol were implemented mortality decreased from 66.7% (1972-1978) to 18.7% (1985-1990).

Adolescent↗

PubMed1992

[Classification and management of complex pelvic trauma].

Complex pelvic traumas are pelvic fractures accompanied by pelvic soft tissue injuries. Mortality in major pelvic fractures with associated soft tissue injuries is high, and these injuries can pose a more complex range of therapeutic problems. Uncontrolled bleeding and septic complications are the main causes of death. There has been extensive work on grading pelvic ring fractures, but less attention has been paid to grading the accompanying soft tissue damage. Therefore, a grading system for pelvic injuries was developed that takes the soft tissue damage into account more than the fracture classification did when used alone. It is a point system that considers the fracture itself, the soft tissue injuries, including lesions in the pelvic organs, vessels and nerves, and the general concomitant injuries. From 1972 to 1990 the clinical course and outcome of 132 patients with complex pelvic traumas were reviewed. The mortality was 34.8%. Eighty-three of the patients (62.9%) underwent immediate laparotomy and in 68 patients (51.7%) open reduction and internal fixation of the unstable pelvic ring were performed. For better primary treatment of patients with complex pelvic injuries, a trauma algorithm is introduced. It leads to important therapeutic steps after brief clinical, ultrasonic and radiological assessments. The major questions in the flow chart take the pelvic ring and hemodynamic instability into account. Immediate laparotomy, surgical control of hemorrhage, and open reduction and internal fixation of an unstable pelvic ring represent the most important requirements for successful treatment.

Adolescent↗

PubMed1992

[Determining indications and osteosynthesis techniques for the pelvic girdle].

1566 patients with fractures of the pelvis were treated at the Department of Traumatology of the Hannover Medical School between 1972 and 1990: 1350 patients had fractures of the pelvic ring, 216 isolated acetabulum fractures, 398 combinations of pelvic ring fractures and acetabular involvement; 718 of these patients were admitted with severe polytrauma. For 1254 patients a complete file was available for clinical and radiological evaluation of fracture distribution, classification (Tile and anatomical location) and concomitant injuries. During the observation period, significant increase in the severity of the trauma, the severity of the pelvic fractures and the rate of internal stabilization, especially of the posterior pelvic ring was observed. The overall mortality after pelvic fractures was 18.1%. This mortality depended significantly on the Hannover Polytrauma Score (PTS) and the associated pelvic and extrapelvic blunt trauma. Internal fixation of pelvic fractures was performed in 195 patients. This experience has now led to standardized procedures for the different fracture locations. With the task of minimizing soft tissue trauma and reducing the implant size, more differentiated treatment of sacral fractures is now applied. Adapted small fragment implants ("local osteosyntheses") can be applied, with an unilateral longitudinal dorsal incision providing an excellent overview over the fracture line. For internal fixation of sacral fractures, involvement (penetration by screws, transfixation) of the sacroiliac joint is avoided whenever possible. In our experience early open reduction and internal fixation of pelvic fractures facilitates the management of these severely injured patients.

Adolescent↗