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Biomedical subjects

U Ambanelli

Publications and source records attributed to U Ambanelli.

At least 37 records · Page 2Linked to original sources
PubMed1982

Indoprofen in rheumatic patients with acute episodes: a multicentre trial.

The results are reported of an open multicentre trial in 228 rheumatic patients with flare-ups. Fourteen centres adopting the same investigational protocol collaborated in the study. Indoprofen was administered for 1 week at a daily dosage of 1000 mg according to a treatment schedule used with success in acute gouty arthritis: a 400 mg i.v. bolus was followed by 200 mg (1 tablet) t.i.d. Subjective (pain) and objective variables were used for reliable assessment of activity. Marked reduction of pain intensity was already noticeable on day 1 of treatment and was followed by progressive improvement in subjective and objective variables for all the diagnoses considered. According to the patients' own overall assessments, results were good or very good in more than 50% of cases. The best outcomes were obtained in low back pain, acute gout and psoriatic arthritis. At the end of treatment only 7.4% of patients experienced no change or deterioration of symptoms. Adverse reactions, consisting mostly of mild and reversible gastrointestinal disturbances, were reported by 9.2% of patients, but only in 1.8% was treatment discontinued. Indoprofen administered according to the above schedule is an appropriate treatment for acute episodes of rheumatic diseases.

Adolescent↗
PubMed1982

Serum antioxidant activity and related variables in rheumatoid arthritis. Behaviour during sulphydrylant treatment.

Some parameters (serum antioxidant activity, -SH groups, ceruloplasmin, copper) involved in the mechanisms of defence against oxygen free radicals were investigated in 25 rheumatoid patients and in 15 control subjects, matched for sex and age. When comparing the results obtained in the two groups, there is in rheumatoid arthritis a marked increase in the serum-specific antioxidant activity, related to ceruloplasmin, ESR, haemoglobin and Ritchie's index and a net decrease in the -SH groups inversely related to Ritchie's index and to ceruloplasmin. On analysing the sensitivity of the various parameters in discriminating between rheumatoid and healthy subjects, it is found that the -SH groups are the most sensitive, followed by the specific antioxidant activity, copper content, and ceruloplasmin. The evaluation of the same parameters in a group of 14 rheumatoid patients before and after 6 months of therapy with an antioxidant drug, viz. Tiopronin, confirms their usefulness in providing information regarding response to the treatment and on the recovery from the disease.

Adult↗
PubMed1981

[Opaque arthrography in the evaluation of gonarthrosis].

The Authors have studied, by means of the arthrographic technique, 24 cases of knee osteoarthrosis in various clinical phases. In the diagnosis of the early phases of the disease, this technique as been helpful in showing alterations, as the widening of the intercartilaginous space, the irregularities of synovial outlines, the enlargement of the normal popliteal space, which common techniques, unusually cannot display. The assay is not needed in the most advanced phases of the disease but it could here as well supply further diagnostic data (i.e. popliteal cyst, etc.). Therefore the authors suggest the arthrographic technique as a complementary assay to the roentgenological one, as well as an elective technique in the early phases of the knee osteoarthrosis.

Adult↗
PubMed1981

[Reactive SH-groups in clinical practice. Methodological notes].

Experimental investigations have been performed in order to point out the extrinsic factors influencing the results of -SH group determination. It has been observed that the anticoagulants normally used to obtain plasma samples, influence the serum -SH groups; in particular, heparin increases and citrate depresses the levels; the most reproducible data were obtained in serum samples. In addition it has been shown that the exposure to light for 6-8 hours lowered the serum -SH groups, whereas darkness prevented these changes. Serum-SH groups were not influenced by the administration of non steroidal anti-inflammatory agents, whereas D-Penicillamine and Tiopronin induced an increase of the -SH levels, ranging between 15-20%. The levels returned to the basal values within two hours from the drug intake. Following the methodological criteria here described it is possible to obtain a good information about the -SH group reserve, which free radicals generated in several diseases could consume. The practical usefulness of the serum -SH group determination in oxidative-peroxidative processes in discussed.

Adult↗
PubMed1981

Evaluation of the activity of anti-inflammatory agents by means of skin tests (M.S.U., SK-SD): comparison with clinical results.

The anti-inflammatory effects of indoprofen were evaluated by skin tests with mono-sodium-urate (M.S.U.) and streptokinase-streptodornase antigen (SK-SD) in 15 patients suffering from inflammatory and degenerative arthropathies. A clear-cut correlation between the short-term response to the M.S.U. skin test and the clinical response was observed in 12 patients.

Anti-Inflammatory Agents↗
PubMed1980

Neo-antigenic expression in rheumatoid synovia?

CEA-like activity was found in eight synovial samples of ten rheumatoid patients and in two samples of patients with recurrent arthrosynovitis. No CEA-like activity was found instead in seven synovial samples of patients with gonarthrosis. The plasmatic values result always within normal range in the non-rheumatoid patients and high only in two cases of rheumatoid ones. Since enzymatic proteolysis induces a synovial CEA-like activity fall, the A.A. think that the antigenic determinants belong to a "protein" locally synthesized.

Adult↗
PubMed1980

[Study of the effects of free radicals produced by ultraviolet rays on viscosity of human synovial fluid. Methodological details].

After having pointed out a method measurement of the synovial Fluid (S.F.) viscosity by means of a white blood cell diluting pipette, obtaining results similar to those of Ostwald's viscometer, the AA have studied the osteoarthrotic S.F. viscosity after Ultra Violet Illumination. The production of Free Radicals induced by U.V., determines a fall of osteoarthrotic S.F. viscosity towards the values found in arthritic S.F..So, the AA, indirectly, confirme the capacity of Free Radicals to induce a S.F. viscosity modification like that provoked by the phlogistic process.

Arthritis, Rheumatoid↗
PubMed1980

The effects of NSAID on monosodium-urate (MSU) skin test and on other in vivo skin tests (SK/SD; PHA).

The authors have pointed out a monosodium-urate (MSU) skin test in vivo, showing a practical usefulness in short-time evaluation of effects of non-steroidal antiphlogistic drugs (NSAID) in man; the isotopic curves, in the area of the skin test, reproduce those obtained in endogenous articular phlogosis. THe authors have studied, at the same time, the actions of NSAID on other skin tests (SK-SD; PHA) which reproduce, in earlier phases of cutaneous reaction, some aspects (erythema, thermographic values, isotopic curves) of 'immediators' phlogosis. The results show that the MSU skin test is more useful in studying the effects of NSAID for the feature of other skin test reactions are affected by many factors.

Anti-Inflammatory Agents↗
PubMed1979

[Cell-mediated immunity after blocking of the H2 lymphocyte receptors].

The effects of cimetidine have been evaluated in 10 normal subjects on cutaneous delayed reactions in vivo, and on E rosette forming cells in vitro, in order to define the significance of the lymphocytes H2 receptors in cell-mediated immunity. The results show the immuno-suppressive activity of histamine, but do not allow us to hypothesize an immuno-regulatory action of cimetidine.

Adult↗
PubMed1979

Suppressor effects of histamine on SK/SD delayed hypersensitivity reactions in man and on E-rosette-forming cells.

The effects of histamine on delayed hypersensitivity cutaneous reactions and on the formation of E-rosettes has been evaluated. In vivo, concentrations of 10(-3.6)M of histamine HCL significantly suppresses the cell-mediated reaction to antigen SK/SD at 24 and at 48 h. In vitro, amine significantly inhibits the formation of E-rosettes in normal subjects. The inhibitory effect is significant at concentrations of 10(-4)M for an incubation period at 37 degrees C of 2 h with lymphocytes. The suppressor effect of histamine in vivo may be mediated by an histamine-induced suppressor factor, while the one in vitro by an increase of intracellular cAMP. No anti-H1 and anti-H2 drugs have been employed but the effects of histamine probably depend on H2-receptors.

Adult↗