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Biomedical subjects

T Zimmermann

Publications and source records attributed to T Zimmermann.

At least 217 records · Page 12Linked to original sources
PubMed1978

Quantitative evaluation of the fetal fatty acid oxidation in the rat.

The fetal fatty acid oxidation has been measured by [14C]-palmitate in vitro oxidation experiments. The fetal fatty acid oxidation was determined to be 0.12 +/- 0.03 mumoles fatty acids/min/litter. The conclusion can be drawn that approximately equal amounts of fetal fatty acids are synthesized, oxidized and transferred from the mother to the fetus.

Animals↗
PubMed1978

Studies on the fatty acid synthesis in maternal and fetal rats.

The fatty acid synthesis as measured by in vitro incorporation of 1-[14C]-acetate and 3H2O into maternal and fetal tissues of the rat has been quantitatively determined. The results showed that because of the endogenous dilution the incorporation of [14C]-acetate does not provide a quantitative measure of fatty acid synthesis. The incorporation of tritium per g of tissue into the fatty acid fraction of maternal and fetal liver (day 21 of pregnancy) was found to be 260 and 130 nmoles per g per min, respectively. The incorporation was lesser in liver of female non-pregnant rats (31 nmoles per g per min) and placenta (4.0 nmoles per g per min). The calculated rates of synthesis of fatty acids were used to support the following views: At the end of gestation about 25% of all fatty acids synthesized within the fetus arise from fetal liver. From day 15 to 21 of pregnancy the fetal fatty acid synthesis supplies about half of the amount of fatty acids which are accumulated due to growth.

Acetates↗
PubMed1978

Quantitative evaluation of the fetal fatty acid synthesis in the rat.

The fetal fatty acid synthesis has been evaluated by 3H2O in vivo incorporation experiments. The results indicate that the fetus synthesizes 0,16 mumoles fatty acids/min/litter. From the results the conclusion can be drawn that the fetus gets fatty acids from the mother and from its own fetal fatty acid synthesis at equal amounts.

Animals↗
PubMed1978

Studies on the hypertriglyceridemia in the pregnant rat.

The in vivo tracer method and in vitro incorporation experiments were used to obtain information on the mechanism responsible for the hypertriglyceridemia found in 21 days pregnant rats. The results indicate that the uptake of plasma free fatty acids (FFA) by liver triglycerides of pregnant rats (2.0 mumoles FFA/min/300 g) did not differ from that of non-pregnant rats (2,1 mumoles FFA/min/300 g). The rate of liver fatty acid synthesis in pregnant rats (0,4 mumoles fatty acids/min/liver) is higher than that of non-pregnant rats (0,05 mumoles fatty acids/min/liver). In non-pregnant female and pregnant rats the turnover rates of plasma chylomicron and VLDL triglycerides were almost identical (about 2.8 mumoles triglyceride fatty acids/min/300 g, and about 2.3 mumoles triglyceride fatty acids/min/300 g, respectively). These various observations, when taken together, strongly suggest that increased hepatic triglyceride production cannot be the mechanism responsible for the hypertriglyceridemia in pregnant rats.

Animals↗
PubMed1977

[Influence of a fat-free diet on the content and synthesis of arachidonic acid in the feto-placental unit of the rat].

In rats receiving a fat-free food throughout the period of pregnancy, the individual fatty acids of total lipids from placenta, total fetus, maternal and fetal serum were determined quantitatively on day 21/22 of pregnancy. Also, the incorporation of 14C-acetate in vitro into placental fatty acids, divided by the number of double bonds, was measured and the rate of synthesis calculated therefrom. The fat-free diet caused a drastic fall of linoleic acid concentration in maternal serum and all fetal compartments. On the contrary, the amount of arachidonic acid remained almost unchanged in fetal serum and total fetus, and even slightly increased in placenta. In the maternal serum, too, the arachidonic acid concentration remained constant under fat-free diet. The observed concentration changes of single fatty acids in the maternal serum are reflected in all fetal compartments and led to a rise in total fatty acids in all sera and tissues studied. The height of rise decreased in the order: maternal serum less than placenta less than fetal serum less than total fetus. The rate of synthesis for arachidonic acid in placenta was on day 21/22 of pregnancy 0.3 (controls) and 0.5 (fat-free diet) micrometer/100 g placenta and hour, being able to cover the placenta's own need to less than one-third. The results suggest that the protection of the feto-placental unit against arachidonic acid deficiency under fat-free diet of the mother is provided mainly by a constant supply of maternal unit with arachidonic acid under normal conditions has to be ensured essentially by the mother.

Animals↗
PubMed1976

Synthesis, turnover and compartment analysis of the free fatty acids in the placenta of rats.

The in vivo tracer method and in vitro acetate incorporation experiments were used to investigate the metabolism of placental free fatty acids. Analysis of data revealed that free fatty acids pass into the fetus from maternal plasma through a small placental compartment, which accounts for only 5 percent of all of the placental free fatty acids. The turnover time of this compartment is 0.57 min. The rate of placental fatty acid synthesis evaluated by both methods is very small and amounts to 0.003 mumols fatty acids/min/all placentas of one litter.

Acetyl-CoA Carboxylase↗
PubMed1975

Transfer of maternal plasma free fatty acids into the rat fetus.

The amount of maternal plasma free fatty acids passing to the fetus has been determined to be 0.09 mumoles fatty acids per min per each litter. Taking account of the increase of the total fetal fatty acid pool due to the fetal growth (0.2 mumoles fatty acids per min for each litter) we conclude that the maternal circulation is the source of about half of fetal fatty acids on day 21 of pregnancy.

Animals↗