Biomedical subjects
Publications and source records attributed to T Young.
The automated studies performed at implant require little extra time and provide essential information for postoperative troubleshooting and patient management. The automated testing and analysis system is but one component in a comprehensive patient management system designed for and dedicated to pacing; the system is an integral part of a complete data management system which includes extensive follow-up and management sections.
Caesarean-derived, colostrum-deprived swine were exposed to a broth culture of a low passage field isolate of Mycoplasma hyopneumoniae by intranasal inoculation. The intranasal-inoculated swine subsequently were commingled with their litter-mates to effect transmission via contact-exposure. Sera were collected from the swine at two to four week intervals for approximately one year postexposure and evaluated by the enzyme-linked immunosorbent assay (ELISA), indirect hemagglutination and complement fixation tests. The intranasal-exposed swine seroconverted earlier, developed higher titers and remained indirect hemagglutination and complement fixation positive longer than the contact-exposed swine. It was concluded that the antibody response of intranasal-exposed swine was artificially high and that sera from such swine were not suitable for evaluating the sensitivity of mycoplasmal pneumonia of swine serodiagnostic tests. The indirect hemagglutination test was relatively insensitive and technically cumbersome and the least promising as a practical field test. The complement fixation test appeared to be slightly more sensitive in detecting early antibody production (especially in contact-exposed swine) but it was the least sensitive in detecting late antibodies. The ELISA was generally the most sensitive procedure. Individual high ELISA titers were from ten to 32 times greater than maximum complement fixation and indirect hemagglutination titers. The most striking difference among the three tests was the persistence of high ELISA titers late in the study. All swine were ELISA positive at necropsy approximately one year postexposure despite the fact that lungs were devoid of lesions and culturally and immunofluorescent negative for M. hyopneumoniae.
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Acute and chronic positive mood changes have been said to occur with running and jogging. It has been suggested that endogenous substances with opioid activity (endorphins) may serve as modulators of mood. The authors report experiments in which mood changes associated with long-distance running were measured by pre- and post-run difference--scores on a mood adjective checklist, the Profile of Mood States (POMS). Following this, the narcotic antagonist, naloxone, was given subcutaneously in double-blind fashion. The dose was 0.8 mg. The POMS was again presented 15 min later, and post-run/post-injection difference scores were obtained. No naloxone effect was found. The failure of naloxone to reverse the running-associated mood shift indicates that endorphins are not involved. The authors discuss the possible physiologic role of endorphins in light of these and other findings.
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The immunoreactivity of lymphocytes from mice bearing large tumors was investigated. As compared to normal lymphocytes, lymphocytes from tumor bearers manifested a lessened proliferative response to T-cell mitogens and were less capable of destroying syngeneic tumor target cells. However, the impaired reactivity of these lymphocytes was improved significantly after washing repeatedly in tissue culture medium in vitro. The increase in cytolytic activity was tumor specific. A membrane-associated suppressive substance was detected in the washing medium which inhibited the cytotoxicity of washed lymphocytes. The effect of suppressive substance was tumor specific and sensitive to treatment with protein A and anti-immunoglobulin antibody, indicating that the suppressive substance contained immunoglobulin. The present findings suggest that a membrane-associated suppressive substance(s) may be in part responsible for the diminished immune responsiveness of lymphocytes from animals bearing large tumors.
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To determine whether Lamaze childbirth preparation is harmless, harmful, or beneficial, 500 consecutive Lamaze-prepared patients were compared to 500 hand-picked controls, matched for age, race, parity, and educational level. Lamaze preparation was found to have a significant beneficial effect in almost every obstetric preformance category. The Lamaze-oriented patients had one-fourth the number of cesarean sections and one-fifth the amount of fetal distress (P less than .005). Postpartum infection, measured both by maternal febrile morbidity and by the incidence of antibiotic use, was one-third that of the controls (P less than .005). Similarly, the "prepared" patients had fewer perineal lacerations and those that occurred were not as serious as those in the control patients (P less than .005). The control patients had three times as many cases of toxemia of pregnancy (P less than .005) and twice as many of prematurity (P less than .05).
This paper reports a sarcoma of the chest wall following postoperative radiation therapy for breast carcinoma. A total of 9346 rads was delivered at a 2-cm tissue depth from two treatment courses separated by a five-year interval. The sarcoma appeared 16 years following the initial radiation course. The existence of two mesenchymal elements in the lesion led to the final diagnosis of malignant mesenchymoma. Criteria for evaluating a possible radiation-induced malignancy are discussed.
Problems with poor compliance when collecting quality of life data (QoL) in randomised clinical trials have prompted investigators to suggest measures to improve data collection. This study sought to look at the practical problems encountered by data managers and nurses in the cross-cultural setting of EORTC trials. A literature search was followed by a poster workshop session at a meeting of the EORTC study Group on Data Management and finally a postal questionnaire. The key problems identified centred around the lack of interest from some clinicians, lack of resources, inadequate protocols and a desire for training in the rationale for collecting QoL data to aid discussions with patients. Despite these problems many data managers and nurses found it rewarding to be on the 'frontline'. Since this study, the EORTC Data Center and in particular the Quality of Life Study Group and the Quality of Life Unit have implemented a number of measures to improve compliance. These include written guidelines for EORTC trials and a training course planned for Autumn 1999.
Leg ulcers that have a mixed arterial and venous component are not always amenable to the solutions currently available. This article examines some of the research-based treatment options.
There is a divide between hospital and community in relation to the availability of wound dressing products. The Drug Tariff is the focus for this divide but is not the only cause of the problem. The issues of communication and education have an important part to play. A multidisciplinary approach is required to address the problems.
Hyperbaric oxygen therapy is emerging as a possible treatment in wound management. It may be delivered systemically or topically. A review of the literature is undertaken to establish the extent of the research base of this practice.
Malodour is a problem for patients with various types of wounds. The problem has a physical and psychological component. Accurate assessment of the cause will facilitate treatment with wound management products that are designed to alleviate the odour.
The issue of the care required by wounded patients infected with human immunodeficiency virus should be addressed by all nursing personnel. The virus can be transmitted through blood, blood products or wound exudate. Promotion of universal precautions should greatly minimise the risk. The patient's infection status is not always known and the problem may not be a major wound but an associated condition.
The incidence of methicillin-resistant Staphylococcus aureus (MRSA) infection is increasing in the UK. MRSA is mainly transmitted via the hands of health-care workers. MRSA can cause colonization or infections. MRSA infections can be fatal.
Overgranulation in wounds causes a delay in wound healing and often produces an increase in wound exudate and is therefore difficult to dress. This article suggests non-traumatic methods of removal in order to preserve the granulation of tissue required for healing.