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Biomedical subjects

T Yano

Publications and source records attributed to T Yano.

At least 703 records · Page 39Linked to original sources
PubMed1987

[Role of natural killer cells in the antimetastatic effect of defibrinogenation with batroxobin].

The antimetastatic effects of defibrinogenation with batroxobin were investigated in normal mice and in mice with depressed or activated natural killer (NK) cell activity. Batroxobin inhibited the formation of lung metastases after intravenous inoculation of the F10 subline of B16 melanoma. Inhibition of NK activity by treatment of mice with anti-asialo GM1 antibody abrogated the antimetastatic effects of Batroxobin. Conversely, augmentation of NK cell activity by poly I:C plus treatment with batroxobin produced additive antimetastatic effects. Studies on the mechanism of interaction between Batroxobin and NK cells revealed that Batroxobin treatment did not affect splenic NK activity in vitro. From these data, it was found that the antimetastatic effects of batroxobin are dependent on the level of NK activity in the host.

Animals↗
PubMed1986

Skin permeability of various non-steroidal anti-inflammatory drugs in man.

The skin permeabilities of a series of eight salicylates and ten non-steroidal anti-inflammatory drugs were investigated in human subjects. The logarithms of % absorption through intact skin and of n-octanol/water partition coefficients (log P) of the test compounds were plotted against one another, and a parabolic relationship was obtained in both compound series.

Absorption↗
PubMed1986

Resectability of the pancreas without producing diabetes, with special reference to pancreatic regeneration.

The exact resectability of the pancreas without producing diabetes was investigated in dogs, with consideration of pancreatic regeneration. Within the first week after major pancreatectomy, acinar cell division occurred, followed by hypertrophy; these changes resulted in an increase in weight of the remnant pancreas. The regeneration rate correlated well with the resection rate, glucose tolerance, and the insulin secretion of the remnant pancreas. Immediately after resection of more than 92% of the pancreas, severe diabetes developed, and the regeneration rate was 29.9 +/- 6.03% three to six weeks after surgery. Twelve weeks after resection of 74-92% of the pancreas, so-called Sandmeyer's diabetes had developed. The regeneration rate was 45.3 +/- 4.22% in the non-diabetic group, but in the diabetic group it proved to be only 15.4 +/- 2.39%. When less than 74% of the pancreas was resected, diabetes did not occur throughout the postoperative observation periods of 3-18 weeks, and the regeneration rate was 5.5 +/- 6.62%. These results suggested that 74% of the pancreas may be removed without producing diabetes.

Animals↗
PubMed1986

Acute aggravation of traumatic carotid-cavernous fistula after venography through the inferior petrosal sinus.

A report is presented on a patient with acute aggravation of traumatic carotid-cavernous fistula after venography through the inferior petrosal sinus. After direct puncture of the internal jugular vein and insertion of the catheter tip to reach the inferior petrosal sinus, venography was conducted, but immediately thereafter bruit decreased and proptosis and chemosis increased. Though the fistula may have been occluded through the endarterial approach, the cause of acute aggravation is considered to have been thrombosis of the inferior petrosal sinus. The risk involved in venography or the transvenous approach for traumatic carotid-cavernous fistulas is discussed.

Accidents, Traffic↗
PubMed1986

A probable new adhesive factor (F42) produced by enterotoxigenic Escherichia coli isolated from pigs.

Three enterotoxigenic Escherichia coli (ETEC) strains (coded 62, 104, and 567/7) isolated from piglets with neonatal diarrhea produced only a thermostable enterotoxin. Although these strains showed mannose-resistant microhemagglutination (MRMH), the responsible factor was serologically different from the known hemagglutinating colonization factors from porcine strains (K88, K99, and F41). Bacterial cells from these strains adhered to HeLa cells and pig brush borders. Electron microscope studies revealed the presence of fimbria-like structures on bacterial cells grown at 37 C but not on cells grown at 18 C. The antiserum prepared from partially purified fimbrial antigen (provisionally called F42) inhibited chicken erythrocyte MRMH caused by these strains as well as adherence of strain 567/7 to HeLa cells and to pig brush borders. These data taken together suggest the existence of a new hemagglutinating adhesin that is different from those so far described for porcine ETEC.

Adhesins, Escherichia coli↗
PubMed1986

[Effect of trapidil on neuropathy in diabetic mice].

Long term oral administration of trapidil at the doses of 20 and 60 mg/kg/day restored the decrease in motor nerve conduction velocity in genetically diabetic mice (C57BL/KsJ db+/db+). Trapidil also suppressed the increase in sorbitol content and the decrease in myoinositol content in the sciatic nerve. The elevation of serum total cholesterol level and the decrease in the ratio of serum HDL-cholesterol level to total cholesterol level were suppressed by trapidil. The blood glucose level and the serum triglyceride level were not affected by the drug administration. These results suggest that trapidil may restore the decrease in nerve conduction velocity in diabetic mice through amelioration of the metabolite abnormalities in nerve and microcirculatory disorders.

Animals↗
PubMed1986

Immediate CO2 storage capacity at the onset of exercise.

The purpose of the present study was to obtain the immediate CO2 storage capacity at the onset of exercise. The CO2 stores at the onset of the exercise were calculated from the difference between the respiratory gas exchange ratio (R) and the metabolic gas exchange ratio (RQ: R obtained at 5.5 min of exercise). The CO2 stores per body weight (CO2 stores/w) were linearly related to the CO2 pressure (P'vCO2) determined by the CO2 rebreathing method (r = 0.713, p less than 0.001), the slope being 0.330 ml/(mmHg X kg). The CO2 stores were then corrected for change in O2 stores with exercise, that defined as total CO2 stores. P'vCO2 was also corrected for the effect of lung-bag volume shrinkage and Haldane effect during CO2 rebreathing, that defined as true PvCO2. The total CO2 stores/w were also related linearly to the true PvCO2 (r = 0.725, p less than 0.001), the slope of the regression line defined as the immediate CO2 storage capacity being 0.650 ml/(mmHg X kg).

Adult↗
PubMed1986

[A case of carcinoma of the esophagogastric junction with marked eosinophil infiltration].

A case of carcinoma of the esophagogastric junction with marked eosinophil infiltration is reported. The patient was a 56-year-old man. He had complained of abdominal discomfort for three months. After examination, a total gastrectomy was performed. Carcinoma of Borrmann III type was found at the esophagogastric junction. Pathohistological findings showed that mucinous adenocarcinoma and marked eosinophil infiltration were present in the primary lesion and metastatic lymph nodes, but there was no evidence of eosinophilia. These results suggested that the tumor might produce eosinophil chemotactic factor. However, the factor could not be detected.

Adenocarcinoma, Mucinous↗
PubMed1986

Relationship between elevation of the labellar threshold after raising by increasing sucrose concentrations and impulses of a single sugar receptor in the LL-type hair of the blowfly.

The threshold for proboscis extension to sucrose stimulus of a single sugar receptor on different labellar hairs was elevated by raising blowflies on higher concentrations of sucrose. The reaction time was defined as the duration from stimulus of a single sugar receptor in the LL-type hair until occurrence of proboscis extension. Reaction times at the threshold concentrations of sucrose did not change among blowfiles raised on different sucrose levels. The average value is about 0.35 s. Relationship of the average number of impulses during 0.35 s to log median acceptance thresholds of sucrose for proboscis extension was linear.

Animals↗
PubMed1986

The roles of the recurrent nerve and the ventral nerve cord in the feeding response of the blowfly, Phormia regina M.

The interaction of sensory activities from internal stretch receptors and from external sugar receptors was studied in relation to proboscis extension and sucrose intake of the blowfly. The tarsal threshold for proboscis extension was elevated in flies after the recurrent nerve was cut. Cutting either the recurrent nerve or the ventral nerve cord did not alter the labellar thresholds for proboscis extension but did influence sucrose intake by prolonging the duration of intake. After the ventral nerve cord was cut, the flies did not stop ingestion as long as sugar receptors in the interpseudotracheal papillae were stimulated. Tonic impulse discharges from the intact recurrent nerve were divided into efferent and afferent types. Efferent impulses from the brain were thought to be transmitted to the hypocerebral ganglion-corpus cardiacum complex for regulation of opening and closing of the foregut valves, of peristaltic movements in the foregut. Afferent impulses were thought to be discharged from the foregut stretch receptors which detected peristaltic movements in the foregut.

Animals↗
PubMed1985

Enzyme immunoassay of 6-ketoprostaglandin F1 alpha in a solid phase.

A solid-phase enzyme immunoassay of 6-ketoprostaglandin F1 alpha (a stable degradation product of prostaglandin I2) was developed in which the hapten molecule was labeled with beta-galactosidase. The antiserum was bound to a polystyrene tube, and the enzyme-labeled and unlabeled 6-ketoprostaglandin F1 alpha were allowed to react in a competitive manner with the immobilized antibody. The activity of the immunologically bound beta-galactosidase was assayed by fluorometry, and correlated with the amount of unlabeled 6-ketoprostaglandin F1 alpha. According to a calibration curve 6-ketoprostaglandin F1 alpha was detectable in a range of 30 fmol-10 pmol. When 6-ketoprostaglandin F1 alpha was extracted from human serum by using an octadecylsilyl silica column (Sep-Pak C18) and the crude extract was subjected to the enzyme immunoassay, the content of 6-ketoprostaglandin F1 alpha was 50-60 pmol/ml of human serum. An endogenous substance(s) which disturbed the immunoreaction and gave such an apparently high concentration of 6-ketoprostaglandin F1 alpha separated from the endogenous 6-ketoprostaglandin F1 alpha by HPLC. With the purified 6-ketoprostaglandin F1 alpha fraction there was a good correlation (r = 0.994) between enzyme immunoassay and radioimmunoassay. The validity of the enzyme immunoassay was confirmed by gas chromatography-selected ion monitoring.

6-Ketoprostaglandin F1 alpha↗