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Biomedical subjects

T Weber

Publications and source records attributed to T Weber.

At least 415 records · Page 23Linked to original sources
PubMed1981

[Pathogenetic interactions between veno-occlusive disease and sideroelastosis pulmonum? (author's transl)].

The clinicopathologic findings in a case of a 66-year-old woman who died 19 days after admission to the hospital for treatment of chronic bronchitis and cor pulmonale are presented. Pathoanatomic investigation revealed striking features of pulmonary sideroelastosis, including fragmentation and iron impregnation of pulmonary elastic fibers. Simultaneously, the pulmonary veins showed alterations similar to those described as "veno-occlusive disease": numerous small and medium-sized pulmonary veins were stenosed or completely obliterated by fibrous intimal connective tissue. The etiology of the pulmonary lesions is discussed on the basis of previously published cases. The possibility of a causal relationship between sideroelastosis and veno-occlusion is considered.

Aged↗
PubMed1980

Physiological responses to low-intensity cardiac rehabilitation exercises.

This study determined the oxygen consumption, heart rate, and blood pressure responses in healthy subjects to calisthenic exercises designed for convalescing patients with cardiac problems. Comparisons of the different exercises showed intersubject variability in oxygen consumption per unit of body weight and in cardiovascular responses. The exercises showing the greatest variability in oxygen consumption, however, were not always the exercises with the greatest variability in heart rate and blood pressure. Upper extremity exercises tended to evoke a greater demand on the cardiovascular system, especially if the isometric component was large. These data suggest the necessity of carefully monitoring cardiovascular response when using a variety of calisthenic exercises in the rehabilitation of patients such as those with cardiac limitations and should provide useful information for prescribing exercise.

Adult↗
PubMed1980

Transcutaneous fetal oxygen tension and fetal heart rate pattern preceding fetal death. Case report.

Simultaneous cardiotocography (CTG) and transcutaneous PO2 (tcPO2) measurements were made in a pregnancy complicated by membrane rupture and cord prolapse at 27 weeks gestation. A Caesarean section was not done because the fetus was judged to have little chance of survival and to be at very high risk of severe brain damage if it did. The fetus weighed 830 g and the CTG changes preceding fetal death were similar to those described by others. The tcPO2 was zero for periods of a few seconds to 20 minutes at 1 to 2 hours before fetal death, and the tcPO2 was constantly zero during the last 50 minutes of fetal life. Tracings showing the tcPO2/CTG changes preceding fetal death are reproduced.

Adult↗
PubMed1980

Continuous fetal pH monitoring and neonatal Apgar score.

Results of continuous fetal tissue pH monitoring were compared to neonatal APGAR scores one minute after delivery in 81 successful tissue pH recordings. The sensitivity of the method (i.e. the ability of the method to find the low APGAR neonates) was 67 per cent using an APGAR score limit between 8 and 9 and a pH limit between 7.20 and 7.21. The specificity (i.e. the ability of the method to find the high APGAR neonates) was 73 per cent using the same limits. The sensitivity and specificity of continuous pH monitoring was equal to or better than the sensitivity and specificity of cardiotocography and discontinuous pH measurements on fetal scalp blood using APGAR score limits between 6 and 7. It is concluded that all fetal monitoring should include monitoring of the fetal pH when a pH electrode which can be used as a routine instrument has been developed. Unfortunately, such an electrode has not been developed yet.

Apgar Score↗
PubMed1980

Perinatal asphyxia in spite of a normal cardiotocogram and a normal acid base state at the time of delivery.

The labor preceding delivery of a depressed neonate with normal acid base status is described. Cardiotocographic (CTG) monitoring was used during the 5.5 hours of active labor. Continuous tissue pH determination was performed during the last 100 minutes of labor. Although the CTG pattern was normal all the time, tissue pH declined to 7.02 one hour before delivery, but reached normal values thereafter. The depression of the neonate could only be explained by the episode of acidosis one hour before delivery.

Acid-Base Equilibrium↗
PubMed1980

Continuous fetal scalp tissue pH monitoring during labor. An analysis of 152 consecutive cases.

Continuous scalp tissue pH monitoring was performed in 152 consecutive cases. The success rate was 53 per cent. The average duration of pH monitoring was 151 minutes (range 0--609 minutes). A good correlation was found between tissue pH at delivery and blood pH in the umbilical artery (r = 0.78) and vein (r = 0.67). In no case with normal tissue pH (more than 7.20) and abnormal CTG was the Apgar score less than 8 one minute after delivery. A normal tissue pH almost always means that the fetus is not asphyxiated, but a low tissue pH reading may be caused by other factors than acidosis of the fetus. Continuous pH monitoring during labor remains a research method.

Electrodes↗
PubMed1980

Interactions of cimetidine and pirenzepine on peptone-stimulated gastric acid secretion in man.

Combinations of H2-receptor antagonists and classical anticholinergics inhibit stimulated gastric acid secretion more than either drug alone. In double blind, placebo controlled, randomised studies we have compared the effects of single and combined intravenous bolus injections of cimetidine and pirenzepine on peptone-stimulated acid secretion and serum gastrin in man. Combined injection of 3.0 mg/kg cimetidine and 0.3 mg/kg pirenzepine suppressed stimulated acid secretion significantly more than either drug alone, and by 90% in healthy volunteers (n = 8) and patients with duodenal ulcer (n = 5). Side-effects (prolactin stimulation, blurred vision) were diminished by reducing the combined dosages to 1.5 mg/kg cimetidine, to 0.075 and 0.15 mg/kg pirenzepine in another series (n = 10). Postprandial gastrin was not affected by any combination. Combination of cimetidine and pirenzepine suppress food-stimulated gastric secretion more effectively than combination of H2-blockers with classical anticholinergics. Pirenzepine--unlike classical anticholinergics--may distinguish between different subclasses of muscarinic receptors and have a more selective antimuscarinic action. Its interaction with H2-receptor antagonists on parietal cell function seems to be synergistic. Such a combination could be of advantage in patients with gastrinoma, in patients with ulcers and hypersecretion resistant to single drug treatment, and in critically ill patients as prophylaxis of stress ulcer bleeding.

Adult↗
PubMed1979

[Therapy of Amanita phalloides poisoning. Results of clinical and experimental studies].

On the basis of experimental and clinical results evidence accumulates that supportive therapy is still the milestone in the therapy of death cap poisoning. Today the letality is 20%. The main cause of the intoxication are the amatoxines which inhibit DNA dependent RNA Polymerase II or B. Parts of the supportive therapy are: diuresis with 150--200 ml urin/hour, careful corrections of disturbances in electrolyte and acid-base-metabolism, oral administration of charcoal and oral gut sterilization. In spite of a multitude of experimental and clinical reports on the effectivity of Penicillin G, thiocticacid and steroids there are no controlled studies to demonstrate the advantage of one regimen over the other. The time course of resorption and excretion of amatoxines clearly shows that hemoperfusion and/or hemodialysis are only of value if applied within the first 24 hours after poisoning. At this time neither anamnestic nor biochemical data give any clues to the probable course of the disease. Heterologous baboon liver perfusion may be lifesaving in coma hepaticum grade IV, but the small amount of cases so far does not yet allow any comments on its effectivity.

Amanita↗
PubMed1979

Continuous measurement of transcutaneous fetal oxygen tension during labour.

Transcutaneous scalp oxygen tension (tcPO2) was measured during labour in 40 fetuses, using a modified Clark electrode (Radiometer, Copenhagen). In 24 of the fetuses the recordings were of good quality during the second stage of labour. After delivery the acid-base status and oxygenation of the umbilical cord blood was measured. A correlation was found between the tcPO2 and umbilical artery oxygen saturation (r = 0.56, p less than 0.01) and umbilical artery PO2 (r = 0.56, p less than 0.01). Furuthermore, a positive correlation was found between the area beneath the recorded tcPO2 curve during the last 10 minutes and the umbilical artery pH (r = 0.50, p less than 0.05). The data suggest that continuous transcutaneous PO2 measurement may be of value in monitoring high risk patients during labour.

Electrodes↗
PubMed1979

Normal values for fetal scalp tissue pH during labour.

Normal values for fetal scalp tissue pH during labour were determined by using a glass electrode (Kontron-Roche). A total of 132 recordings was obtained and 84 (64 per cent) were of good quality. After a good quality recording had been obtained, there were 64 infants with an Apgar score of 9 or 10 at one and five minutes after delivery. The 64 recordings showed pH values (Mean +/- 2SEM) of 7.38 +/- 0.12 six hours before delivery and 7.28 +/- 0.12 at the time of delivery. Between the 5th and 55th minutes of the second stage of labour the pH (Mean +/- 2SEM) fell from 7.30 +/- 0.14 to 7.20 +/- 0.13.

Female↗
PubMed1979

Pregnancy complications following conization of the uterine cervix (I).

The literature on the course of pregnancies following conization of the uterine cervix has been studied. It is demonstrated that an evaluation of the possible effect of conization upon subsequent pregnancy should be based upon a comparison of either pregnancies before and after conization or upon a comparison between pregnancies in women with a previous conization and in a control group of women without conization. In both cases the possible influence of conization can be evaluated only if the patient material is described as regards age, parity, number of previous pregnancies, smoking habits, etc., factors which may all influence the course of pregnancy. None of the previous publications have described the patient material sufficiently, and most studies have not tried to set up control groups. Due to these deficiencies we do not find it justified that conization leads to reduced fertility, increased frequency of spontaneous abortion, nor to increased perinatal mortality. An increased prematurity rate may not be rejected, however, but this point has not been adequately evaluated in the previous papers.

Abortion, Induced↗
PubMed1979

Pregnancy complications following conization of the uterine cervix (II).

The effect of conization upon the course of pregnancy and the fertility has been evaluated. 44 women had a total of 66 pregnancies following conization. These 44 women were compared with an age-matched group of non-conized women, as well as with a group of non-conized women matched for both age and parity. There were more smokers among conized than among non-conized women. All other descriptive variables were found to be without significant differences between the groups compared. There was no significant difference in the frequency of spontaneous and induced abortion, prematurity or cesarean section between conized and non-conized women. The second stage of labor was found to be protracted in conized women. Fertility judged by the "latent period"--the time elapsed from the couple started sexual intercourse without use of contraception to the present pregnancy--showed no difference between conized and non-conized women. We conclude that although a greater number of patients is necessary to permit definite conclusions concerning the risk of pregnancy and delivery complications in conized women, it is of special interest that the present study did not demonstrate an increased risk of spontaneous abortion nor of prematurity.

Abortion, Spontaneous↗
PubMed1979

Improved lysozyme assay in biological fluids.

We describe a simple, rapid, sensitive, and highly reproducible assay for lysozyme, with use of concentrated cell suspensions of Micrococcus lysodeikticus in Tris-buffered glycerol/water (40/60 by vol), pH 7.5. Stored at -20 degrees C, the cells' susceptibility to lysozyme remains unaltered over long periods. Almost identical concentration curves were obtained with different aliquots of the same preparation during eight months. Lysozyme activity was reflected in the decrease in absorbance of the reaction mixture after incubation for 15 min at 37 degrees C. Concentrations of egg-white lysozyme as low as 0.02 mg/L can be accurately assayed.

Biological Assay↗