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Biomedical subjects

T Vogl

Publications and source records attributed to T Vogl.

At least 163 records · Page 9Linked to original sources

[MRI of the nasopharynx with Gd-DTPA: its value and differential diagnostic criteria].

81 patients with masses in the nasopharynx were examined by MRI and CT. In cases of primary lesions of the nasopharynx (such as carcinomas and fibromas), MRI with Gd-DTPA was superior to CT. Secondary tumors involving the nasopharynx were visualized equally well with MRI with Gd-DTPA and CT. The results show that MRI should be the primary method of examination in lesions of the nasopharynx. CT is a secondary procedure useful for showing small areas of bone erosion. MRI with the paramagnetic contrast medium Gd-DTPA permits differentiation between inflammatory, cystic and neoplastic masses.

Angiography↗

[The value of MRT of the thorax in congenital tracheal stenoses].

MRI of the thorax was performed in 24 children aged between six weeks and five years, in whom a tracheal stenosis had been demonstrated by bronchoscopy. Since bronchoscopy can only demonstrate the interior of the trachea, various imaging methods, such as CT and angiography, were used to demonstrate the topography and cause of the tracheal stenosis. MRI has shown that the most common cause of a stenosis in the central section of the trachea is focal compression by an aberrant brachiocephalic trunk (10 cases). Stenosis of the distal trachea could be due to anomalies of the aortic arch (5 cases), a dilated pulmonary artery (4 cases) or a soft tissue mass (3 cases). In all these patients, MRI was greatly superior to the conventional methods. By using a special technique, MRI made it possible to clarify the cause and localisation of a tracheal stenosis by a non-invasive examination.

Aorta, Thoracic↗

Paragangliomas of the jugular bulb and carotid body: MR imaging with short sequences and Gd-DTPA enhancement.

Twenty-six patients with glomus jugulare (16), glomus tympanicum (three), or carotid glomus (seven) tumors were examined with contrast-enhanced CT scans and MR scans without and with Gd-DTPA. MR and CT scans had similar sensitivities, but the enhanced MR scans were diagnostically more specific than either CT or nonenhanced MR. Dynamic MR scanning permitted measurement of the degree of Gd-DTPA enhancement over time. We recommend contrast-enhanced MR with short sequences and a dynamic approach in patients with suspected carotid, tympanic, and jugular paragangliomas.

Carotid Body Tumor↗

[Magnetic resonance tomography of the parotid gland: plain diagnosis and Gd-DTPA].

Pathological lesions of the parotid gland were examined comparatively with different examination sequences both plain and with the contrast medium Gd-DTPA. There were 36 benign lesions (parotitis, Sjögren's syndrome, adenoma, etc.) and 24 malignant tumours (squamous cell carcinoma, adenocarcinoma, adenoid cystic carcinoma etc.) Examinations were carried out at 1.0 T with long and short spin echo sequences in transverse and frontal layer orientation before and after application of Gd-DTPA as contrast medium. In the patients suffering from parotitis the best results were obtained with plain T1 and T2 sequences; the contrast medium Gd-DTPA remained without superior diagnostic relevance. However, in Sjögren's syndrome (myoepithelial sialadenitis) administration of the contrast medium always yielded a characteristic honeycomblike pattern. In benign and malignant space-occupying growths MRI supplied additional diagnostic information with Gd-DTPA in respect of defining the tumour borderlines and paths of infiltration. MRI is now a significant diagnostic tool in inflammatory and tumorous lesions of the parotid gland.

Adenocarcinoma↗

[Diseases of the aerodigestive tract and of the soft tissues of the neck. Comparison of MRI and CT].

CT and MRT are compared with each other in examinations of the aerodigestive tract in 250 patients. MRT was found to be the method of highest sensitivity and specificity after intravenous administration of the contrast medium Gd-DTPA. Magnetic resonance tomography was found to be clearly superior to computed tomography on account of the 3-dimensional imaging possibilities, improved contrasting of soft parts, and freedom from artifacts. In space-occupying growths of the nasopharynx, oropharynx and hypopharynx, the primary use of MRT must be considered mandatory in diagnostic strategy planning. CT occupies the second rank and can be used for optimised visualisation of small osseous lesions and for digital subtraction angiography (DSA). The latter plays an important role in the analysis of selective vascular supply and in diagnosis before intraarterial chemotherapy. In respect of processed in the soft tissues of the neck, pathological lesions of the lymph nodes, vessels, soft parts and cervical processes are differentiated (n = 139). For the diagnosis of the entire neck region, magnetic resonance tomography with the additional use of the contrast medium Gd-DTPA proves to be the method with the highest rate of accuracy. In processes of the soft tissues, sonography can also be employed as a primary diagnostic tool. However, in certain localisations and lesions this method can only be used with certain restrictions. According to the present state of the art, computed tomography must be considered as a secondary procedure in the diagnosis of the neck region.

Head↗

[Magnetic resonance tomographic studies of paragangliomas of the glomus caroticum and glomus jugulare using Gd-DTPA].

The value of magnetic resonance tomography in the diagnosis of paragangliomas in the head and neck has been studied and compared with CT and angiography. Magnetic resonance tomography on its own equals the accuracy of CT, but the use of Gd-DTPA improves diagnostic accuracy. In 19 patients with a glomus jugulare tumour, MR tomography with Gd-DTPA accurately diagnosed all tumours larger than 5 mm. In seven patients with a carotid body tumour, it was possible to arrive at an exact differential diagnosis. Sensitivity was better than that of CT or of sonography. Where there is clinical suspicion of a glomus tumour, magnetic resonance tomography with Gd-DTPA should be the first investigation; if there is a positive finding, angiography should be carried out to demonstrate the circle of Willis.

Carotid Body Tumor↗

[Nuclear magnetic resonance tomography using gadolinium-DTPA in the diagnosis of spinal lesions].

In spinal lesions GD-DTPA has led to a better diagnosis of tumors concerning the extent and differential diagnosis. Important indications for the application of GD-DTPA are intramedullary tumors: excellent information with respect to extent and differentiation cyst from tumor. At extramedullary intradural tumors we got distinction of extramedullary from intramedullary tumors and more information in the differential diagnosis for example in cases of neurinomas and meningiomas. Additional information is also obtained by means of GD-DTPA in extradural tumors: better delineation from the myelon, better possibilities to differentiate between meningiomas, neurinomas and scar and tumor.

Breast Neoplasms↗

[Results of magnetic resonance tomography of the temporomandibular joint using optimized surface coils].

One hundred temporo-mandibular joints were examined with a super-conducting nuclear resonance tomograph (1.0 Tesla) using various high resolution surface coils. The optimal method proved to be a spin echo sequence with a repetition time of 1,000 msec and an echo period of 28 msec with a 4 mm slice width. There were significant advantages from the non-invasive MRT diagnosis of the temporo-mandibular joints when compared with CT and with arthrography in recognising abnormal discs, changes in the tissues and for post-operative control.

Adult↗

Indications for the use of Gd-DTPA in MRI of the central nervous system. Experiences in patients with cerebral and spinal diseases.

A total of 209 intracranial and spinal diseases were evaluated before and after administration of the paramagnetic contrast agent Gd-DTPA. The results justify the use of Gd-DTPA in intracranial and spinal tumors for better visualization of location and extent of a lesion and for better tissue differentiation. In inflammatory diseases Gd-DTPA allows the differentiation between active and chronic lesions.

Brain Neoplasms↗

[Arterial and venous digital subtraction angiography. A current study technic for otorhinolaryngology].

Digital subtraction angiography (DSA) is a rather new radiographic technique for imaging different vascular alterations, particularly in the head and neck area, and can replace angiography in most cases. Nevertheless, routine application of DSA - intravenously or intraarterially - seems to present a problem to many clinicists. In the present paper, therefore, we try to introduce these important techniques by means of several examples from patients who have undergone these procedures to demonstrate the actual indications of DSA for oto-rhino-laryngological diseases.

Carotid Artery Diseases↗

The induction of chromosome aberrations during the course of radiation therapy for morbus Hodgkin.

In a patient with Morbus Hodgkin, structural aberrations of the chromosome type in peripheral lymphocytes were analyzed during radiation therapy (accumulated target dose 44.6 Gy: 22 fractions of 1.8 Gy each and 2 fractions of 2.5 Gy each at the end of the therapy). The blood was sampled about 5 min after a fraction and/or 24, 48, or 72 h thereafter. The frequency of dicentric chromosomes:acentric fragments:centric ring chromosomes is 37:14:1 throughout the therapy. Independent of the time of blood sampling after a fraction, the distributions of dicentrics and acentrics are overdisperse and represent negative binomial distributions. The yields from these aberrations, as determined during the course of radiotherapy, are best fitted to a linear-quadratic function with a negative quadratic term. The two dose-effect curves (blood sampling about 5 min and 24 to 72 h after a fraction) of dicentrics and acentrics do not differ significantly. Up to an accumulated target dose of about 20 Gy the percentages of cells with chromosome aberrations increase to about 48 to 65% and, at this level, remain constant until the end of therapy.

Adult↗

[Diseases of the lymphatic system of the head and neck region. A comparative study of MRI and CT].

The diagnostic possibilities of magnetic resonance imaging compared with computed tomography in lymphomas and pathological enlargement of the lymph nodes in the head and neck region are presented. Whereas plain MRI examinations showed the same diagnostic sensitivity as CT, application of the paramagnetic contrast medium Gd-DTPA in 50 of 87 patients clearly increased diagnostic accuracy. Signal intensities of T1- or T2-weighted images before therapy (operation, chemotherapy, radiotherapy) and after administration of Gd-DTPA were enhanced, compared with posttherapeutic and plain examinations. An increase after therapy in two patients signalled a relapse or residual tumour tissue; a decrease in three cases was evaluated as response to therapy. Other differential diagnostic processes such as lipomas, neurinomas, glomus tumours etc. were differentiated with the help of signal intensity curves after administration of contrast media and the use of a gradient echo sequence TR/TE = 30/12 msec with a flip angle of 30 degrees. Differentiation of tissue based on morphological criteria such as homogeneity of tumour tissue or the delineation against surrounding tissue structures showed in the case of Hodgkin's disease and inflammatory diseases mainly homogeneous elements without ring-shaped structure. Non-Hodgkin lymphomas had a predominantly homogeneous structure. In squamous cell carcinomas MR revealed in two cases a ring-shaped enhancement.

Adult↗

[Meningioma of the sphenoid bone with involvement of the tympanic cavity].

Meningiomas are the most common benign neoplasms of the central nervous system, while meningiomas involving temporal bone are quite rare. If these tumours originate from the sphenoid they usually infiltrate the middle cranial fossa, the orbit, the cavernous sinus and the internal carotid artery. Only a small number of sphenoidal meningiomas infiltrating the middle ear have been reported so far. In these cases, differentiation from other middle ear diseases, particularly glomus tumour and chronical otitis media, is difficult. In this study the case of a sphenoidal meningioma involving the temporal bone and the middle ear is presented. The importance of computerized tomography and particularly MR tomography in evaluating intracranial and intratympanic meningiomas is discussed.

Biopsy↗

[Magnetic resonance tomography in tumors of the salivary glands--a diagnostic advantage?].

40 patients with clinically palpable salivary gland masses were included in a prospective study to compare magnetic resonance imaging to computed tomography. MRI has proved superior to CT not only in imaging primary lesions but also in diagnosing local and regional recurrences. In evaluating border structures, signal intensity, T1- and T2-values of space occupying lesions, we can determine the tumour status. Besides, we can define to some extent the internal architecture of the salivary gland or intra-resp. periglandular lymph node masses. Better contrast resolution and more specificity can be obtained by the use of contrast medium gadolinium-DTPA. Even small intraglandular and periglandular masses can be clearly distinguished from the sourrounding structures. At present, magnetic resonance imaging offers the diagnostic potency of both sonography and computed tomography. The advantages of MRI and our present indications in imaging salivary gland masses are discussed.

Adenocarcinoma↗

[Computerized tomography imaging of choanal atresia].

Choanal atresia is a rare malformation of the nose. If it occurs bilaterally, it may cause life-threatening complications shortly after birth. The disease is mainly diagnosed clinically. Only few cases have been presented and documented by means of radiologic procedures. In particular, CT presentation of this malformation has to our knowledge not been published to date.

Choanal Atresia↗

[Effect of in vivo nuclear magnetic resonance tomography on somatosensory and visual evoked potentials in the human].

By means of registration of somatosensory (SSEP) and visual (VEP) evoked potentials under the influence of different magnetic and electromagnetic fields of Magnetic Resonance we investigated the influence of Magnetic Resonance Imaging (MRI) on human nervous system (all measurements with an 1.0 T MR imager are performed outside and inside the static magnetic field, before and after MR imaging). In vivo experiments on 20 healthy volunteers show in SSEP registrations as well as in VEP-registrations no measurable influence on nerve conduction. The measured latencies before and after MR imaging are found inside the standard values which are valid for healthy volunteers. In vivo experiments at field-strengthens up to 1.0 Tesla show no significant changes of the central and peripheral conduction velocity with human beings.

Adult↗