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Biomedical subjects

T Usui

Publications and source records attributed to T Usui.

At least 469 records · Page 26Linked to original sources
PubMed1985

[Treatment of hypercalciuria found in urolithiasis patients].

To reduce urinary calcium excretion, 50 mg of hydrochlorothiazide per day was given to 35 patients with hypercalciuria. Urinary calcium decreased significantly after 4 weeks of drug administration, but urinary magnesium did not change. Magnesium calcium ratio increased significantly. Although serious side effects were not seen, serum potassium decreased and serum uric acid increased significantly. From these results thiazide seems to be a useful and safe medicine to reduce urinary calcium excretion. The dose and method of administration require further examination because the patients have to take the drug for a long time.

Adolescent↗
PubMed1984

Loss of epidermal growth factor receptor on the renal neoplasm induced in vivo with Xenotropic pseudotype Kirsten murine sarcoma virus.

A characteristic feature of normal rat kidney (NRK) cells in their ability to bind epidermal growth factor (EGF) and loss of the ability to bind EGF in the renal neoplasm induced in vivo with C type RNA virus were demonstrated. Maximal binding capacity and apparent dissociation constant of NRK cells were 3.36 femtomoles of EGF bound per 10(6) cells and 2.85 X 10(-11) M, respectively. The binding of EGF to transformed cell in vivo with Xenotropic pseudotype Kirsten murine sarcoma virus was abolished.

Animals↗
PubMed1984

Lipid peroxidation in rabbit reticulocytes.

Lipid peroxides in rabbit erythrocytes and plasma were determined while anemia was induced by daily bleeding. They increased as reticulocytes increased and returned to normal with the morphological transformation to mature cells.

Anemia↗
PubMed1984

Pituitary abnormalities detected by high resolution computed tomography with thin slices in primary hypothyroidism and Turner syndrome.

Pituitary hyperplasia, microadenoma or an empty sella was detected in three children with primary hypothyroidism and three with Turner syndrome with the use of high resolution contrast-enhanced computed tomography (CT) with thin slices. Hyperplasia or microadenoma of the pituitary gland frequently occurs secondary to primary hypothyroidism and gonadal dysgenesis, and recognition of these results may eliminate unnecessary surgery in favor of hormone replacement therapy. High resolution contrast-enhanced CT, especially coronal CT, with thin slices is very helpful in demonstrating these pituitary abnormalities.

Adenoma↗
PubMed1984

Significance of erythrocyte lipid peroxidation and superoxide dismutase activity in a patient with idiopathic pulmonary haemosiderosis.

In a patient with idiopathic pulmonary haemosiderosis, lipid peroxidation of erythrocytes and their superoxide dismutase activity were determined. The latter was found to be decreased, and the erythrocytes showed easy peroxidisability, which was shown by vulnerability to hydrogen peroxide and a marked elevation of iron-catalysed lipid peroxidation in addition to a higher basal malondialdehyde level, an end product of lipid peroxidation. These findings were correlated with haemolysis, iron-deficiency anaemia and a shortened survival of erythrocytes. Although the aetiological significance of our observations still remains to be clarified, it appears that antioxidant enzymes and the peroxidative reactivity of erythrocytes should be carefully evaluated in other patients with idiopathic pulmonary haemosiderosis.

Child↗
PubMed1984

Differentiation of mouse leukemic M1 cells induced by polyprenoids.

We screened several synthetic polyprenoids about their capacity of cell differentiation using mouse myeloid leukemic M1 cells, and found that 3, 7, 11, 15, 19,-pentamethyleicosa-2, 6, 10, 14, 18-pentaenol (Geranyl Farnesol) could induce the differentiation of M1 cells into macrophage-like cells. The optimal concentration of this compound for its induction capacity was approximately 2 X 10(-5) M. The induced differentiation related markers were morphological change in M1 cells, Fc receptors for IgG (Fc gamma), and non-specific esterase activity. However, phagocytic activity was poorly induced. This suggests that most of Geranyl Farnesol treated cells may be retained functionally incomplete macrophages. The presence of cycloheximide at 1 X 10(-7)M or the incubation of M1 cells at 4 degrees C completely blocked the induction of Fc gamma, suggesting the induction of Fc gamma required protein synthesis. The treatment of M1 cells with Geranyl Farnesol resulted in suppression of DNA and RNA synthesis. Further analysis of RNA metabolism suggested that the suppression of RNA synthesis was mainly due to the decrease of rRNA. On the other hand the synthesis and turnover of polyA-containing RNA (mRNA) rather increased.

Animals↗
PubMed1984

Isolated growth hormone deficiency type 1A in a Japanese family.

A Japanese family is described in which a 7-year-old child had isolated growth hormone deficiency type 1A, as described by Illig et al. He was shown to be homozygous for a deletion of the structural gene for hGH (hGH-N gene). Initially his growth rate responded well to hGH administration, but rapidly he developed high titers of hGH antibodies, and growth ceased. At that time, a somatomedin-C generation test gave negative results, suggesting that the growth arrest was related to the inability of hGH to generate somatomedin. Both parents were heterozygous for the hGH-N gene deletion and had a low hGH response to arginine and L-dopa tolerance tests, but had normal basal somatomedin-C levels and normal somatomedin-C generation tests. This family is the fourth to be reported with IGHD type 1A caused by deletion of the hGH-N gene. This cause of growth hormone deficiency can be distinguished from other severe autosomal recessive types of hGH deficiency by the demonstration of the deletion of hGH-N gene using restriction endonuclease analysis.

Adult↗
PubMed1984

Effect of anticancer drugs on renal neoplasm induced with xenotropic pseudotype kirsten murine sarcoma virus.

The sensitivity of a renal neoplasm induced in vivo with C type RNA virus to anticancer drugs was evaluated. The proliferation rate of the virus induced neoplasm cells depended on the concentrations of antimetabolites, alkylates and antibiotics, but not depends on that of alkaloids. An inhibitory effect of drugs on the virus induced neoplasm cells became evident in the following order, i.e., antimetabolites, alkylates, antibiotics and then alkaloids.

Animals↗
PubMed1984

Zinc, copper, manganese, and selenium metabolism in thyroid disease.

This study was designed to evaluate trace metal metabolism in adults with thyroid diseases. Erythrocyte zinc values were significantly lower than normal in hyperthyroidism and higher in hypothyroidism. A significantly higher than normal urinary excretion of zinc was observed in hyperthyroidism. The mean concentrations of plasma and erythrocyte copper were significantly above normal in hyperthyroidism. Plasma selenium levels were significantly lower than normal in hyperthyroidism. No statistically significant difference was found in plasma zinc, erythrocyte manganese, or urine copper values between patients with thyroid diseases and healthy controls. The erythrocyte manganese content correlated well with thyroxine and triiodothyronine levels. Plasma prealbumin and retinol-binding protein correlated well with the erythrocyte zinc content but not with plasma zinc levels. There was no correlation between erythrocyte superoxide dismutase activity and erythrocyte copper or zinc concentrations. The results of this study suggest that the metabolism of zinc, copper, manganese, and selenium is abnormal in thyroid diseases.

Adolescent↗
PubMed1984

Plasma selenium concentration in healthy Japanese children and adults determined by flameless atomic absorption spectrophotometry.

This study showed a rapid and direct method for determining selenium concentration in plasma by flameless atomic absorption spectrophotometry, and differences in plasma selenium concentration in healthy children and adults. A direct method is possible, since selenium is heat stable in the presence of nickel. With this method, the recovery of selenium added to plasma was 100.3 +/- 5.7%, and the relative standard deviation in repeated determinations of pooled plasma selenium was 3.0% and 6.8%. The plasma selenium concentration in adults was 99.4 +/- 12.5 ng/ml, lower than reported concentrations from the United States and Canada, and higher than those from New Zealand. These variations may reflect dietary habits, bioavailability of selenium compounds in diet, racial difference, or different analytical methods. The mean concentration of plasma selenium at 1 to 6 months of age (51.0 +/- 13.1 ng/ml) was significantly lower than in adults (p less than 0.001); it increased gradually and steadily to the adult level with age. This age-related difference of plasma selenium level is similar to that reported previously.

Adolescent↗