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Biomedical subjects

T Umeda

Publications and source records attributed to T Umeda.

At least 343 records · Page 19Linked to original sources
PubMed1980

Cross-sectional echocardiographic observation of the short axis views of the left ventricle in hypertrophic cardiomyopathy.

Short axis views of the left ventricle were studied in 68 patients with hypertrophic cardiomyopathy (HCM) and 20 healthy persons using cross-sectional echocardiography. Configurations of the short axis view of the left ventricular cavity at the level of the papillary muscles in HCM were classified into 2 types, dumbbell and mushroom, which were formed by the position of papillary muscles. Antrior dislocation of the papillary muscles was seen in the dumbbell type, and marked hypertrophy of the papillary muscles in the proper position was seen in the mushroom type. Dumbbell shape (50 patients) was observed in the patients with marked hypertrophy in the basal protion of interventricular septum. Mushroom shape (18 patients) was seen in the patients with hypertrophy around the apex of the heart except for in a few patients. Areas of the papillary muscles (AP) and the left ventricular cavity (ALV) were measured and AP/ALV + AP ratio was calculated. The AP/ALV + AP ratio in HCM was significantly larger than that in the healthy persons, but no difference was seen between these 2 groups of HCM. It should be noted that the position of the hypertrophied papillary muscles is closely related to the distribution of hypertrophy in HCM.

Adult↗
PubMed1979

Restoration by levamisole of E-rosette formation and its abrogation by autochthonous serum from patients with bladder cancer.

Incubation in vitro of lymphocytes from bladder cancer patients with levamisole (40 microgram/ml) resulted in a rise of the number of E-rosette forming cells from 39.2 +/- 11.8% to 57.5 +/- 11.3% (p less than 0.005). The same effect was observed when levamisole was administrated 150 mg/day for 3 days to the patients. The stimulatory effect of levamisole was abrogated when the lymphocytes were first incubated with levamisole and afterwards with 50% autochthonous serum from the patient. With more diluted serum concentrations (from 0.5% to 1%), the response decreased, and the response was not observed with allogeneic serum. When lymphocytes from healthy donors were incubated with 50% serum from bladder cancer patients, there were no significant changes in numbers of E-rosette forming cells. It was presumed that the suppression of E-rosette forming cells from the patients with bladder cancer was caused by blocking the receptor sites for sheep red blood cells by autochthonous serum components and that levamisole eliminated such substances from the cryptic sites on the surface of the lymphocytes.

Binding Sites↗