Biomedical subjects
T Turner
Publications and source records attributed to T Turner.
Percutaneous extensor tenotomy for chronic tennis elbow: an office procedure.
Explore the source record for details and available documents.
Mental health advocacy: paradigm or panacea?
In May, 1982, the Ontario Minister of Health set out the bare essentials of a proposed advocacy program for psychiatric patients. In November, a Toronto family doctor, actively involved in civil rights issues, was appointed to develop and coordinate the program. In May, 1983, eleven advocates were appointed to advise and assist patients in each of the province's ten psychiatric hospitals. The advocates came from various backgrounds--legal, psychiatric nursing and social work, labour negotiation, pastoral and other public services. This paper describes the design, function and scope of Canada's first province-wide psychiatric patient advocate system and some major issues identified in the first year.
The need for nurses.
Explore the source record for details and available documents.
Genetic linkage analysis of epidermolysis bullosa simplex, Köbner type.
Genetic linkage relationships between a range of marker loci and the locus for epidermolysis bullosa simplex (EBS), Köbner type, were examined in a single kindred. A positive lod score of 1.2 at theta = 0.2 was found for Fy. To test the clinical observation that Köbner and Weber-Cockayne types may be the same disease determined by different alleles, published lod scores from definite Weber-Cockayne families were added to those from this study. A lod score of 1.8 was found at theta = 0.2. This value falls to 1.5 at theta = 0.2 when all families other than Ogna type are included. The Köbner variant studied is not closely linked to GPT and is therefore distinct from EBS1 (Ogna type). Linkage analysis is consistent with an hypothesis that Köbner and Weber-Cockayne types are determined by a single locus; however, further evidence is needed before this locus can be designated EBS2 and assigned to chromosome 1.
Patient advocacy: the Ontario experience.
Explore the source record for details and available documents.
The role of opioid peptides in the hormonal responses to acute exercise in man.
Opioid involvement in the physiological and hormonal responses to acute exercise was investigated in six normal male subjects. Each was exercised to 40% (mild exercise) and 80% (severe exercise) of his previously determined maximal oxygen consumption on two occasions, with and without an infusion of high-dose naloxone. The exercise task was a bicycle ergometer; mild and severe exercise were performed for 20 min each, followed by a recovery period. Exercise produced the expected increases in heart rate, blood pressure, ventilation, tidal volume, respiratory rate, oxygen consumption and carbon dioxide production. After severe exercise, naloxone infusion increased ventilation from 94.8 +/- 4.9 litres/min to 105.7 +/- 5.0 litres/min (P less than 0.05), but had no effect on any of the other physiological variables. Exercise-induced changes in several hormones and metabolites were noted, including elevations in circulating lactate, growth hormone (GH), prolactin, cortisol, luteinizing hormone (LH), follicle stimulating hormone (FSH), adrenaline noradrenaline, plasma renin activity (PRA) and aldosterone. There was no change in plasma met-enkephalin. Naloxone infusion produced the expected increases in LH and cortisol, but also significantly enhanced the elevations in prolactin, adrenaline, noradrenaline, plasma renin activity and aldosterone (P less than 0.05). Psychological questionnaires revealed minor mood changes after exercise, but no evidence was found for the suggested 'high' or euphoria of exercise. Effort was perceived as greater during the naloxone infusion than the saline infusion in every subject.(ABSTRACT TRUNCATED AT 250 WORDS)
Obsessive-compulsive neurosis with conduct disorder in adolescence: a report of two cases.
Two adolescents are described presenting with obsessive-compulsive neurosis and conduct disorder. The presence of conduct disorder is in marked contrast to the compliance and over-control characteristic of obsessionality, and was found to give rise to great difficulties in instigating and carrying through a programme of response-prevention for the obsessive-compulsive symptoms.
Effects of DRG's on staffing in skilled nursing facilities.
Explore the source record for details and available documents.
What do you do with your dead?
Explore the source record for details and available documents.
Problems of booster vaccinations.
Explore the source record for details and available documents.
Total surface hip arthroplasty in dogs using a fiber metal composite as a fixation method.
A total hip surface replacement was performed on 13 adult mongrel dogs using a porous fiber metal composite for fixation to bone. Titanium fiber composite rings were molded onto cylindrical acetabular prostheses, and cobalt-chrome fiber inserts were sintered onto the cast cobalt-chrome femoral components. The animals were allowed unrestricted walking. Four dogs were sacrificed between 3 and 5 weeks, five at 7 weeks, one with a femoral neck fracture at 12 weeks, and three at 26 weeks. Bone ingrowth was accomplished in 20 of the 26 prosthetic components. This included 12 femoral components and eight acetabular. The main reason for failure appeared to be inadequate primary fixation, secondary to either poor design or technical difficulties experienced during the surgical procedure.
Household pets as a potential reservoir for Clostridium difficile infection.
The purpose of this study was to assess the carriage of Clostridium difficile by household pets to determine their potential as a reservoir of infection. The selective cycloserine-cefoxitin medium was used for C difficile isolation, and tissue culture used for detection of cytotoxin. Carriage of C difficile by household pets was found to be common (23%). The carriage tends to be transient and does not appear to be associated with gastrointestinal disease. Although carriage was higher in animals who had antecedent antibiotic treatment (31%) compared to those which had not (19%), the differences were not statistically significant. In most cases non-cytotoxigenic strains were isolated. Of the cytotoxigenic strains isolated at least one strain was pathogenic in a well documented animal model of human disease. Both cytotoxigenic and non-cytotoxigenic strains of C difficile could be isolated from the environment of the animals studied.
One hundred years of small animal practice.
Explore the source record for details and available documents.
A clinical trial on the early detection and correction of haemostatic defects in selected high-risk neonates.
Low birth weight infants, preterm infants with respiratory distress syndrome and mature infants with asphyxia were screened for coagulation abnormalities as soon as possible after birth. Those with abnormal haemostasis were assigned to control or treatment groups and, in the latter case, were given prothrombin complex concentrate, cryoprecipitate or platelet concentrate as appropriate. This treatment was largely successful in correcting haemostatic defects but did not result in any change in mortality. There was no evidence of adverse or beneficial side-effects of treatment.
Down's/Turner's mosaicism. Double aneuploidy as a rare cause of missed prenatal diagnosis of chromosomal abnormality.
Two babies with Down's/Turner's mosaic karyotype are reported. In each, because of advanced maternal age, chromosomal analysis had been carried out on the fluid obtained by amniocentesis in early pregnancy. Only the 46,X+ 21 cell line grew in the specimens and the extra 21 chromosome was wrongly identified as a Y chromosome, so that the fetus was thought to have a normal male karyotype, 46,XY. At birth both babies were phenotypically female with features predominantly of Down's syndrome and the correct karyotype was then identified. Twenty cases of this rare chromosomal abnormality are reviewed and one other living child who had been similarly wrongly diagnosed is reported.
Environmental dermatitis: changing patterns.
Patch tests in 1000 cases of contact allergic dermatitis observed between 1972 and 1978 are recorded in detail, and compared in general with patch tests in a previously recorded 1000 cases of contact allergic dermatitis between 1964 adn 1972. The routine use, since 1974, of patch tests as advised by the International Contact Dermatitis Research Group has increased the detection of dermatitis caused by nickel, paraphenylene-diamine and related dyes, formaldehyde and perfumes (balsam of Peru), which indicates that aimed patch tests alone may be inadequate. The number of cases of dermatitis caused by antifungal agents and topical antihistamines decreased after Commonwealth and State legislation prohibiting their use was passed.