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Biomedical subjects

T Theorell

Publications and source records attributed to T Theorell.

At least 199 records · Page 11Linked to original sources
PubMed1979

A simple ballistocardiographic measure (IJ/HI amplitude ratio) in relation to electrocardiographic evidence of ischaemic heart disease.

A series of eighteen monozygotic and thirteen dizygotic twin pairs originally selected in 19=7--1968 because of the presence of symptoms of ischemic heart disease in at least one of the pair members was subjected to after examination including ultra-low frequency ballistocardiography. The ratio between IJ and HI amplitudes in the ballistocardiogram was used as an index of myocardial mechanical function. The IJ/HI ratio had a repeatability coefficient of 0.82 before and/or after psychiatric interview. The mean ratio did not change significantly after psychiatric interview. The measure was demonstrated to be independent of height, weight, age, heart rate and systolic and diastolic blood pressure and negatively correlated with a measure of somatic anxiety. The ratio was highly significantly correlated with electrocardiographic evidence of ischemic heart disease. The IJ/HI ratio showed a better discrimination than qualitative readings according to Starr and furthermore has the advantage of providing a continuous measure. The ratio seemed to be more influenced by the functional state of the myocardium than by genetic factors.

Aged↗
PubMed1979

Circumstances around the onset of a myocardial infarction. A study of factors relevant to the perception of symptoms and to the delay in arriving at a coronary care unit.

Psychosocial factors, experienced pain and anxiety in relation to patient delay were studied in 100 patients admitted for suspected acute myocardial infarction (AMI). More severe pain was reported by women, by those who had recently consulted a physician, who experienced severe anxiety, who fell ill away from their place of work, or who possessed little medical knowledge. These patients tried to get relief from pain by resting. Patients experiencing more severe anxiety were younger, had not consulted a physician recently, had poor medical knowledge, belonged to lower socio-economic groups or were impatient. These patients also sought relief from pain by resting. Pain, but not anxiety, was related to delay. Long delay was seen more often in patients who did not believe they had suffered an AMI and who were psychologically inactive prior to the onset of pain. Recent physician consultation, failure to call for help and belonging to lower socio-economic groups were also related to long delay. Medical knowledge was unrelated to patient delay. Patients with a low degree of pain rarely reported considerable anxiety, whereas several patients with severe pain had little or no anxiety.

Acute Disease↗
PubMed1978

Electrocardiographic changes during total energy deprivation (fasting).

The effect of 10 days of total energy deprivation (fasting) on ECG reactions was evaluated in 14 healthy normal-weight males. The heart rate and the ratios between QRS and T wave amplitudes in leads I and II decreased significantly, as did body weight and blood glucose levels. The urinary excretion of adrenaline increased. It is concluded that other hormonal (e.g. thyroidal), neural and metabolic mechanisms are of greater significance for the heart than the sympatho-adreno-medullary activity during fasting. T wave abnormality without an abnormal Q wave and without other clinical symptoms was noted in one subject on the 8th day of starvation and remained abnormal for more than a year.

Adult↗
PubMed1978

Non-invasive methods for evaluating the importance of heart rate and atrial activity in cardiac pacing. Results of ballistocardiography and digital plethysmography studies in six patients with heart block.

Ultralow frequency ballistocardiography (UFB) and digital pulse plethysmography (DPP) were performed in six patients with an external artificial pacemaker system. UFB was used mainly to evaluate the force of contraction of the left ventricle (IJ amplitude) and DPP for evaluating relative changes in the peripheral pulse volume. Four patients were studied at 40, 50, 60, 70, 80, 90 and 100 beats/min. There was a significant decrease (p less than 0.001) in LJ and pulse amplitudes when the heart rate increased from 40 to 100 beats/min. A positive correlation between relative IJ and pulse amplitude was observed in all cases studied. In beat-to-beat analysis it was found that the importance of the PR interval for the IJ and pulse amplitudes varied between patients. It is concluded that both UFB and DPP may be of value in clinical practice for evaluating hemodynamics in patients with slow spontaneous heart rate. The methods may be of help in selecting the most effective type of pacemaker for the individual patient.

Aged↗
PubMed1977

'Workload' and risk of myocardial infarction--a prospective psychosocial analysis.

The study group consisted of 5187 building construction workers aged 41-61 in Greater Stockholm who had all responded to a psychosocial questionnaire and had been in full-time work without long-lasting illness episodes in the year before the study. A factor analysis of about 60 psychosocial variables was performed, and on this basis three indices were formed. The study group was followed for two years in official registers yielding information on morbidity and mortality. The 'workload' index was demonstrated to be significantly associated with subsequent risk of myocardial infarction.

Adult↗
PubMed1977

Energy deprivation in man--methodological problems and possibilities.

Various approaches to the study of physiological and behavioural effects of energy deprivation are presented and discussed. An experimental, total energy deprivation in 20 healthy human volunteers during an 11-day period, preceded and followed by 4-day control periods, is described. Potentially pathogenic reactions which occurred in spite of precautions are analysed. It is concluded that the present controlled real-life model with acute total energy deprivation serves the purpose of studying hypotheses concerning potentially pathogenic mechanisms occurring in deprivational situations under conditions of natural and man-made catastrophes.

Adult↗
PubMed1976

Scaling of life changes: differences between three diagnostic groups and between recently experienced and non-experienced events.

Myocardial infarction (MI), neurosis, and lower back pain patients, and matched control subjects estimated the subjective importance of 46 life change events. They estimated (1) the degree of effort necessary in adjusting to them, and (2) how upsetting they were. The estimates of "adjustment" were on average higher than those of "upset". The neurosis patients gave higher values than their controls. Total life change scores were calculated (1) according to the subjects' estimates of recently experienced life events, and (2) according to their estimates of recently non-experienced events. It was found that the first type of scores discriminated better between the two groups than the second type. The results indicate that different forms of psychological scaling may be used to improve the predictive value of life change data.

Adaptation, Psychological↗
PubMed1976

Day and night work: changes in cholesterol, uric acid, glucose and potassium in serum and in circadian patterns of urinary catecholamine excretion. A longitudinal cross-over study of railway workers.

Two groups of railway workers (n = 16 and n = 17) have been followed on their place of work during a period of shifts between day and night work. Catecholamine excretion in the urine and blood levels of lipids, glucose, uric acid, potassium and calcium were followed during the different phases of shift work. Dramatic fluctuations were noted in the diurnal pattern of catecholamine excretion during and after night work. Significant elevations in the serum levels of cholesterol, glucose, uric acid and potassium were observed during the first week after a night shift, and these changes could not be explained on the basis of shifts in the diurnal pattern or changes in dietary or other habits.

Adult↗