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Biomedical subjects

T Theorell

Publications and source records attributed to T Theorell.

At least 181 records · Page 10Linked to original sources
PubMed1982

Clinical characteristics of 18-year-old men with elevated blood pressure.

Twenty "hypertensive" 18-year-old men (systolic BP greater than or equal to 146 and/or diastolic BP greater than or equal to 90 mmHg) from the screening examinations of a military draught bureau were compared with 17 normotensive (systolic BP 124-131) and 12 hypotensive (systolic BP 100-106) subjects. The hypertensive subjects were on average taller, showed more often ECG evidence of sympathoadrenomedullary overactivity, tended to excrete more adrenaline in the urine during a standardized psychological stress test, had higher serum levels of sodium and potassium and reported more frequently family prevalence of hypertension than the normotensives and hypotensives. Non-participating subjects without verified hypertension had higher mean relative weight than any of the study groups. Only one hypertensive subject showed dilated pulmonary vessels on chest X-ray and borderline evidence of mild left ventricular hypertrophy. None of the hypertensive subjects showed evidence of decreased glomerular filtration rate or endocrine disorder. The subjects in both comparison groups showed frequently ECG evidence of parasympathetic activity. The hypotensive group had a lower average relative body weight than the other groups.

Adolescent↗
PubMed1981

Circadian variations in cardiovascular parameters during sleep deprivation. A noninvasive study of young healthy men.

Twelve subjects were kept awake for 64 h under conditions of isolation from external time cues. Activity was sedentary and kept as constant as possible over time, as was intake of food and drink. Cardiovascular variables--blood pressure, heart rate, contractility (IJ-amplitude from ballistocardiogram), T-wave amplitude, QRS, PQ and QT intervals--were assessed every 3 h. At the same intervals, urine samples for catecholamine analysis were obtained. Data were analyzed by analysis of variance and cosinor techniques. Adrenaline excretion showed a pronounced circadian rhythm. Noradrenaline excretion and IJ amplitude showed much weaker rhythmicity, statistically significant only with the cosinor technique. The remaining variables showed no rhythmicity with either technique. It was concluded that constant conditions (including sleep deprivation) markedly disturb or even obliterate the circadian rhythms of cardiovascular variables and urinary noradrenaline excretion. It was also concluded that most of the amplitude of cardiovascular circadian rhythms measured under habitual sleep/wake conditions must be due to the alternation between sleeping and waking. The present data do not, however, rule out the existence of selfsustained circadian rhythmicity in cardiovascular variables; a design including continuous wakefulness may well have concealed endogenous low-amplitude rhythms.

Adult↗
PubMed1981

Relation between arrhythmic sensations, cardiac arrhythmias and psychological profile.

The relation between arrhythmic sensations and objective findings of ectopic arrhythmic activity was studied in 150 middle-aged men. Objective arrhythmias were studied by 24-hour Holter monitoring and subjective symptoms assessed by a questionnaire and a dairy protocol during the ECG recording. Psychological characteristics were described by means of a personality inventory, the Emotions Profile Index. No direct relationship was found between subjective symptoms and objective findings of cardiac arrhythmias. Those men, however, who complained of arrhythmic sensations but had no clinically important arrhythmias exhibited a few specific characteristics. They had no signs of organic heart disease and appeared less trustful and more aggressive than those with arrhythmias.

Adult↗
PubMed1981

Job decision latitude, job demands, and cardiovascular disease: a prospective study of Swedish men.

The association between specific job characteristics and subsequent cardiovascular disease was tested using a large random sample of the male working Swedish population. The prospective development of coronary heart disease (CHD) symptoms and signs was analyzed using a multivariate logistic regression technique. Additionally, a case-controlled study was used to analyze all cardiovascular-cerebrovascular (CHD-CVD) deaths during a six-year follow-up. The indicator of CHD symptoms and signs was validated in a six-year prospective study of CHD deaths (standardized mortality ratio 5.0; p less than or equal to .001). A hectic and psychologically demanding job increases the risk of developing CHD symptoms and signs (standardized odds ratio 1.29, p less than 0.25) and premature CHD-CVD death (relative risk 4.0, p less than .01). Low decision latitude-expressed as low intellectual discretion and low personal schedule freedom-is also associated with increased risk of cardiovascular disease. Low intellectual discretion predicts the development of CHD symptoms and signs (SOR 1.44, p less than .01), while low personal schedule freedom among the majority of workers with the minimum statutory education increases the risk of CHD-CVD death (RR 6.6, p less than .0002). The associations exist after controlling for age, education, smoking, and overweight.

Cardiovascular Diseases↗
PubMed1981

Pre-beta 1-lipoprotein in patients with ischemic heart disease. Genetic determination and relation to early insulin response.

The genetic determination of pre-beta 1-lipoprotein and its relation to insulin response was studied in 18 male monozygotic and 13 male dizygotic twin pairs, aged 51-74. They had been selected from the Swedish Twin Registry by means of an angina pectoris questionnaire. Results revealed a heritability index for the pre-beta 1-lipoprotein, determined quantitatively, to be as high as 0.94. The subjects in whom pre-beta 1-lipoprotein was present exhibited a significantly delayed early insulin response compared to subjects without this lipoprotein fraction. Our data seem to justify the use of pre-beta 1-lipoprotein as a genetic marker. Data also indicate that important metabolic differences may exist between pre-beta 1+ and pre-beta 1- individuals, and it is possible that such differences may explain in part an increased susceptibility to ischemic heart disease for those possessing the pre-beta 1 fraction.

Aged↗
PubMed1980

Impact of Pattern A behavior on ischemic heart disease when controlling for conventional risk indicators.

The presence of Pattern A behavior was assessed by means of the Structured Interview in three groups of Swedish men, 50 with manifest ischemic heart disease (IHD), 50 with risk indicators for IHD and fifty healthy men. They were also examined for presence of hypertension, hyperlipidemia, hyperglycemia, obesity, impaired pulmonary function, smoking and alcohol consumption. The relative risk of having developed clinical IHD, associated with the presence of Pattern A behavior was found to be four times greater with than without such behavior. When conventional risk indicators were controlled for, by means of a multivariate confounder score, this relative risk was reduced to 2.7.

Adult↗
PubMed1980

Relation between ventricular arrhythmias and psychological profile.

The association between psychological characteristics and ventricular arrhythmias was investigated in 150 men (50 with manifest IHD, 50 with risk indicators of IHD and 50 healthy men). Arrhythmias were recorded with 24-hour Holter monitoring. Psychological characteristics were assessed by the Emotions Profile Index and the Structured Interview for pattern A behaviour. A depressive emotional state was associated with prognostically severe ventricular arrhythmia in healthy men, but not in men with overt IHD or risk indicators of IHD. When clinical characteristics and age were taken into account, depressiveness was-among healthy men-the second most important factor after high age. The results suggest that-in absence of IHD or other cardiovascular disease-a depressive emotional state may participate in the formation of ventricular arrhythmia.

Adult↗
PubMed1980

Life events and manifestations of ischemic heart disease. Epidemiological and psychophysiological aspects.

Recent psychophysiological and epidemiological evidence from both retrospective and prospective research is discussed with regard to relationship between life events and ischemic heart disease. Differences in the perception of and in the physiological reactions to life events in the real life situation of myocardial infarction patients are analyzed with respect to both the individual coping styles, that are learned, and the highly complex underlying hemodynamical mechanisms, that are genetically determined to some extent. It is argued that a more complete understanding of this relationship could form a basis for preventive action.

Adult↗
PubMed1980

A comparison between Finnish immigrants and native Swedes in the greater Stockholm region-social and medical risk indicators of ischemic heart disease.

A random sample of 105 Finnish 35-59-year-old male immigrants in the catchment area of Huddinge hospital was drawn and 105 age- and sex-matched native Swedes living in the same area. From the Finnish 71 participated and from the Swedes, 77. Most immigrants had been residing in the region for many years. Many had grown up in medium-sized municipalities in Finland, particularly in the province of Karelia. They differed from the native Swedes with regard to many social variables. Thus, the immigrants had lower incomes, were more frequently exposed to noise at work and reported more sickness absenteeism during the year preceding the study. The immigrants had significantly more often than the native Swedes at least one conventional risk indicator of ischemic heart disease. They were also demonstrated to have abnormally low high density lipoprotein cholesterol levels significantly more frequently than native Swedes. Several of the variables studied did not differentiate the groups from one another. Thus, there was no indication of any difference in total alcohol ingestion or in Type A behaviour prevalence.

Adult↗