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Biomedical subjects

T Teshima

Publications and source records attributed to T Teshima.

At least 199 records · Page 11Linked to original sources
PubMed1989

[Local control after radiation therapy for T1N0M0 glottic carcinoma].

From 1978 through 1984, we had 151 patients with T1N0M0 glottic carcinoma. They were treated by radiotherapy with 4MV x-ray in parallel opposing field of 5 X 5 cm2 or 6 X 6 cm2. The total dose was 60 Gy/30 fractions/6 weeks. The local control rate was 88.1%, the local recurrence being noted in 18 cases (11.9%). Of these 18 cases, 6 underwent partial laryngectomy, and 10 total laryngectomy. The remaining two cases died: one refused further treatment for recurrence and the other died in spite of total laryngectomy due to recurrence after partial laryngectomy. The salvage rate was 94.1%. The cumulative survival rate was 82.6% in Tla, 71.5% in Tlb and 81.1% in 151 T1N0. The tumor response was poor in the presence of lesion occupying the whole length of the vocal cord. Also, in the cases with ulcer formation or thickened vocal cord as seen on laryngogram, local control rate was not good. Better results will be achieved by improving treatment techniques, specially by improving dose-distribution by wedge-filtered technique and method for immobilization in plastic shell during radio-therapy.

Adult↗
PubMed1989

[The role of radiotherapy in hospice care].

The aim of palliative radiotherapy for the terminally ill is to improve the quality of the remaining span of life. From November 1982 to September 1987, 69 patients in the Seirei Hospice have been treated with such radiotherapy, and symptomatic relief was obtained in 64% of these patients. Radiotherapy also proved useful in achieving an improvement in their performance status. While the aim of hospice care is not directed towards treatment of the underlying disease, the use of radiotherapy is considered to have an important role in hospice care.

Hospices↗
PubMed1989

[Prognostic factors in patients with brain metastases from lung carcinoma].

Between September 1980 to December 1984, 85 patients with brain metastases from lung carcinoma were consecutively evaluated and were entered into the first prospective randomized trial. Since January 1985, the second prospective randomized trial was started based on the result of the first trial, i.e., lactate dehydrogenase (LDH) as the most important prognostic factor. We analyzed neurological improvement and survival of 79 patients, who were entered into the second trial until November 1988, compared with the first trial. This preliminary result suggests that LDH may also be an important prognostic factor in the second trial.

Brain Neoplasms↗
PubMed1989

[Radiation therapy with or without cisplatin in esophageal carcinoma].

Of 74 patients with an esophageal carcinoma, 26 were treated with a combined modality of radiotherapy and cisplatin (CDDP group), and 48 were treated with radiotherapy alone (RT group). Sixteen patients were salvaged by surgery after radiotherapy. Fifty-two patients were found to have a loco-regional disease (RT group: 34 patients; CDDP group: 18 patients) and 22 patients had a distant metastasis at the time of the initial treatment (RT group: 14 patients; CDDP group; 8 patients). For those with a loco-regional disease, the response rate was for those in the CDDP group and 34% for those in the RT group. For non-surgically salvaged cases, the median survival was 12 months and there was no statistically significant difference between the CDDP and the RT groups. For the surgically salvaged cases, 2 out of 7 patients in the RT group and 5 out of 9 patients an in the CDDP group are still alive. Additionally, four T3 cases were salvaged by surgery in the CDDP group.

Aged↗
PubMed1989

[Radiation therapy of early glottic cancer (T1N0M0); retrospective review of historical control].

From November 1977 through April 1982, a total of 91 patients with early glottic cancer (T1N0M0) were treated with the open field technique of 4 MV X-ray using parallel opposed fields in bandage. Radiation dose administered was 60 Gy in 30 fractions over 6-week periods. Actuarial 5-year disease-free survival rate was 88.7%. Significant prognostic factors of local control were tumor length, tumor width, tumor type, tumor response at 40 Gy and 60 Gy. Ultimate local control rate by salvage surgery was 97% and voice preservation rate was 91%.

Actuarial Analysis↗
PubMed1989

[Cis-diamminedichloroplatinum (CDDP)-radiation therapy of an advanced nasopharyngeal carcinoma].

Between November 1983 and May 1985, 11 patients with locally advanced (stage IV) nasopharyngeal carcinoma were treated using a combination of Cis-diamminedichloroplatinum and radiation therapy (CDDP-RT group). In this group, 7 patients were given radical RT, sandwiched between 1 course of CDDP (70 mg/m2) before and 1 after. Four patients were given 1 course of CDDP prior to RT. Treatment results were compared with 32 patients (stage IV) who were treated with radiation therapy alone (RT group). These groups showed almost the same local control rate and distant relapses. There was no significant difference in the actuarial and relapse-free survival between the CDDP-RT group and the RT group. As a side effect, severe mucositis of the oral cavity was observed in 4 patients (36%) of the CDDP-RT group in contrast with 3 patients (9%) of the RT group (p less than 0.05).

Adolescent↗
PubMed1988

Mucociliary clearance in pulmonary vascular disease.

The mucociliary clearance function was studied by radioaerosol inhalation lung cinescintigraphy and its quantification in 8 patients with pulmonary vascular diseases; pulmonary embolism, 5 cases, and right pulmonary artery hypoplasia, pulmonary arteriovenous fistulas, aortitis syndrome, 1 case each. The mucociliary clearance function was found to be well maintained in pulmonary vascular diseases unless ventilation was disturbed. There was no difference in the mucociliary clearance function between pulmonary embolism and other pulmonary vascular diseases.

Adolescent↗
PubMed1988

High-dose rate intracavitary therapy for carcinoma of the uterine cervix: II. Risk factors for rectal complication.

From August 1978 through December 1982, a total of 267 patients with carcinoma of the uterine cervix were treated using remote afterloading high-dose rate intracavitary therapy (RALS) with non-rigid applicator at our department. The data from 199 previously untreated patients with standard application out of 267 were available for this analysis of rectal complication. The incidence of moderate to severe rectal complication (Kottmeier's grade 2 and 3) was 7% (13/199). Cox's regression model was used for the analysis of risk factors for rectal complication in which even minor injuries (grade 1) were included. By using this method, it was clear that the first significant risk factor was z-coordinates of weighted geometric center (WGC-z) (p = 0.0007) and the second corresponding factor was rectal TDF (p = 0.0082), the sum of the rectal dose measured by semiconductor dosimeter (ICD-5) and the dose of external whole pelvic irradiation. From the analysis of application pattern of intracavitary sources, WGC-z indicated the approximation of intracavitary sources to the anterior wall of rectum quantitatively and three-dimensionally. The significance of rectal TDF also implied that the monitoring of rectal dose by ICD-5 had an important role for the prediction and prevention of rectal complication after RALS.

Analysis of Variance↗
PubMed1988

Sialolithiasis of a Blandin's gland duct.

A case of sialolithiasis in a Blandin's gland duct is reported. Although minor salivary glands calculi are not uncommon, Blandin's glands are rare sites of occurrence. In this case, a calculus without decalcification is reported. Not only clinico-pathological features but also electron probe micro analyzer plus energy dispersive X-ray spectroscopy studies are presented. These studies reveal that phosphorus is contained in only the basophilic part of the calculus and sulphur in both the basophilic and the eosinophilic parts.

Adult↗
PubMed1988

A new decalcifying technique for immunohistochemical studies of calcified tissue, especially applicable to cell surface marker demonstration.

We have developed a new decalcifying technique for use in light and electron microscopy studies utilizing immunohistochemical staining of calcified tissues. Specimens containing calcified tissues can be adequately decalcified at a pH of 7.1-7.4 and temperature of -5 degrees C, without freezing, by use of a solution containing EDTA, sodium hydroxide, and glycerol. In this study, Leu-2a, Leu-3a, Leu-4, Leu-7, Leu-12, Leu-14, Leu-M1, Leu-M2, Leu-M3, and HLA-DR-positive cells in destructive lesions of bone tissues from patients with rheumatoid arthritis and osteomyelitis were successfully detected immunohistochemically. Furthermore, the presence of HLA-DR antigen on the surface of the infiltrating cells in the same lesions could be demonstrated using the immunoelectron microscopic technique. The results reported here have not previously been obtainable using conventional decalcifying techniques.

Antibodies, Monoclonal↗
PubMed1988

Radiation therapy for carcinoma of the hypopharynx with special reference to nodal control.

From October 1977 through December 1983, 61 patients with carcinoma of the hypopharynx were treated with radiation therapy (RT) and surgery or with RT alone. Five-year survival rates by N-stage, according to the TNM classification by UICC (1978), were 52% for N0 cases, 23% for N1, and 17% for N2-3 (N1 vs. N2-3, not significant). For N1-3 cases, corresponding figures by level of cervical nodal involvement by UICC (1978) were 29% for level 3 cases, 15% for level 2, and 8% for level 4 (level 3 vs. level 4, p less than 0.04). Therefore, the level of cervical nodal involvement was a more useful prognosticator for patients with nodal metastasis than the N-stage. Effective nodal control for patients with clinically positive nodes (N1-3) was obtained with a combination of neck node dissection and RT of 50 Gy or more. For N0 cases, elective RT of 50 Gy or more, encompassing an adequate field, was required.

Adult↗
PubMed1988

Radiation therapy combined with or without chemotherapy for limited extent of non-small cell lung carcinoma.

From July 1977 to December 1983, 130 patients with limited extent of non-small cell lung carcinoma received radiotherapy of more then 30 Gy combined with or without chemotherapy at the Center for Adult Diseases, Osaka, Japan. Four treatment arms were evaluated: RT alone, RT following chemotherapy, RT following low dose concurrent irradiation with chemotherapy (LDC-RT), and RT concurrently used with chemotherapy. Complete regression of local and regional tumor was produced in 5% and partial regression 58%. Among these four treatment arms LDC-RT showed the highest response rate (88%), while no difference in long-term survival was apparent. According to the RT dose, survival of cases who received RT doses above 50 Gy was better than that of cases under 50 Gy in spite of the combination with chemotherapy. These data suggest that adjuvant chemotherapy has no favorable impact against the survival. Concerning the prognostic factor, tumor response after treatment, general performance status and N stage were important.

Antineoplastic Combined Chemotherapy Protocols↗