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T Terashima

Publications and source records attributed to T Terashima.

At least 145 records · Page 8Linked to original sources
PubMed1991

The intracortical position of pyramidal tract neurons in the motor cortex of the reeler changes from postnatal day 10 to adulthood.

To determine whether or not the intracortical distribution pattern of pyramidal tract (PT) neurons in the motor cortex (hindlimb area) of normal and reeler mutant mice changes during early postnatal development of the cortex, we injected HRP into the pyramidal decussation of postnatal day (P) 8 and adult animals of the normal and reeler strains, and killed the animals 2 days later. In the normal P10 and adult mice, such an injection resulted in a band of labelled neurons confined to the layer of large pyramids (LP), suggesting that the intracortical localization of PT neurons does not change from P10 to adulthood in the normal strain. In the P10 and adult reeler mice, labelled PT neurons were scattered radially from the deepest zone to the superficial zone of the motor cortex. However, while the HRP-labelled PT neurons are located bilaminarly in both the deepest zone and the superficial zone of the motor cortex of the P10 reeler mouse, the majority of PT neurons were found in the upper third of the motor cortex of the adult reeler mouse. Thus, the intracortical distribution pattern of PT neurons of the reeler mouse changes during the postnatal period.

Animals↗
PubMed1991

Peptide tyrosine tyrosine-positive ovarian carcinoid tumor arising from a dermoid cyst.

A case of ovarian carcinoid tumor of the trabecular type is presented. The small carcinoid tumor was found incidentally in a resected dermoid cyst. Histologically, the tumor was surrounded by a smooth muscle layer with focal stromal invasion. Non-carcinoid papillary mucosa and a few small glands, simulating the mucosa of the fallopian tube and remnant müllerian glands, respectively, were also present adjacent to the carcinoid tumor and enclosed by the same smooth muscle layer. The tumor cells revealed argyrophilia, and were positive for peptide tyrosine tyrosine (PYY) in the cytoplasm and for CEA in part of the luminal surface. This case was considered to be a rare ovarian carcinoid tumor arising from a dermoid cyst, without association of struma ovarii. PYY may be a potential marker for determining the histogenesis of ovarian carcinoid tumors.

Adult↗
PubMed1991

Postnatal development of the pontine projections from the visual cortex of the mouse.

We studied the postnatal development of the corticopontine tract in mice by the injection of the axon tracer DiI into the visual cortex. In the postnatal day (P) 0.5 mouse, labeled pyramidal tract fibers pass through the internal capsule and cerebral peduncle, grow over the basilar pontine gray, and enter into the medullary pyramid (in this study, P0 refers to the first 24 hours after birth). Small collateral branches arise from these pyramidal tract fibers on P0.5-1.0, and elongate quickly into the basilar pontine gray around P2-4. These collateral branches give off many secondary branches on P4 and form the bright terminal zone in the rostral portion of the lateral basilar pontine gray on P9. In the P16 mouse, this terminal zone is more restricted, suggesting, on the basis of the anterograde DiI labeling technique, that the visual corticopontine projection matures by P16. DiI-labeled pyramidal tract fibers distal to the branching point of the pontine collaterals are found during the postnatal two weeks, but disappear by the later stages. We conclude that the visual corticopontine tract develops as collateral branches of the transient pyramidal tract fibers arising from the visual cortex of the mouse, as just described in the rat (O'Leary and Terashima, Neuron 1:901-910, 1988).

Animals↗
PubMed1991

[Postoperative brain metastasis from esophageal carcinomas: report of 4 cases].

Out of 83 cases received resection of primary esophageal lesion, 4 patients were affected by metastatic brain tumor which was reported to rarely occur. All 4 patients had symptoms of central nervous system. Three of them were diagnosed by CT and the other one at autopsy. All of the primary esophageal tumors were advanced and of histological stage III or IV. They located in the middle or lower thoracic esophagus. Brain tumor of one case was removed and this case was of progression free at the last presentation. The other 3 cases were not received resection of metastatic brain tumors and died. All of 3 were autopsied and two of them had no metastasis in the lung. Therefore, it was considered that these hematogenic metastases were not through lung filtrations but through other routes, which Batson O. V. experimentally proved and designated as vertebral vein system in 1940. It is concluded that aggressive surgical intervention to metastatic brain tumors was beneficial with regard to prognosis for cases without other metastatic lesions.

Aged↗
PubMed1991

[The influence of exercise loading for a long period on the renal function of the children with mesangial proliferative glomerulonephritis].

We have studied the influence of exercise on renal function in chronic glomerulonephritis with mesangial proliferation. The mesangial proliferative glomerulonephritis consisted of (1) IgA nephropathy (Mild group), (2) IgA nephropathy (Moderate group), (3) diffuse proliferative glomerulonephritis = DPGN (Mild group), were divided 2 groups between (A) exercise loading groups and (B) control groups, respectively. The period of observation was one or one year 6 months. None of cases deteriorated in the renal function during the period of observation were found in the exercise loading groups. The prescription of exercise for permits with mesangial proliferative glomerulonephritis indicates approximately 130 values of %BMR, which is estimated by calorie counter.

Adolescent↗
PubMed1991

[Dislocated neurons and neural network: hodological study of the motor cortex of the reeler mutant mouse].

Reeler, an autosomal recessive mutation in mice, causes cytoarchitectonic abnormalities of cerebral cortex, which are characterized by malposition of neurons. We examined hodological systems of the reeler motor cortex. The results are described as follows. (1) In normal controls, corticospinal tract neurons retrogradely labeled after the injection of HRP ioto the lumbar cord were situated only in layer V (layer of large pyramids: LP). In the reeler, by contrast, the labeled corticospinal tract neurons were scattered diffusely throughout all levels of the corresponding area. (2) In the normal controls, callosal commissural neurons retrogradely labeled after the HRP injection into the motor cortex were distributed in a bilaminar pattern such that the largest number of cells were located in the supragranular layers II (layer of small pyramids; SP) and III (layer of medium pyramids; MP), and in the infragranular layer V (LP). In the reeler mutant mice, callosal commissural neurons were found in all cortical layers, but two-thirds were situated in the lower half of the cortex. (3) In the normal controls, most of the thalamocortical neurons labeled after HRP injection into the motor cortex were located in the ventrolateral nucleus, the lateral division of the ventrobasal nucleus, the central lateral, paracentral and central intralaminar nuclei, and the medial division of the posterior complex. In the reeler mutant mice, retrogradely labeled neurons were again found in the nuclei referred to above, and the distribution pattern and morphology of HRP-filled neurons were also similar to those of normal controls. In the reeler, thalamocortical fibers took an abnormal course within the motor cortex: they ascended obliquely from the white matter to the pial surface and then descended obliquely to the deeper layers. These results strongly suggest that dislocated neurons project correctly to normally-situated and/or abnormally situated target(s).

Animals↗
PubMed1991

[A case of congenital antithrombin II deficiency with pulmonary infarction].

A 48-year-old woman was admitted because of increased bloody sputum. Since she had had a history of repeated thrombotic episodes including venous thrombosis in the lower limbs (21 year old) and pulmonary emboli developing into pulmonary infarction (41 years old), the patient was treated with anti-coagulant therapy using Warfarin for 7 years. Warfarin was discontinued after admission and heparin was administered instead at a relatively low dose of 5,000 units daily, resulting in a considerable diminution of hemoptysis. Unfortunately however, it caused a relapse of active thrombosis associated not only with a significant increase of the product of fibrinolysis (FDP), LDH and GOT but with a concomitant decrease of the platelet count. Hematological examinations concerning coagulation and fibrinolysis remained within a normal range except for the serum concentration of antithrombin III (AT III) and its functional property with regard to the heparin cofactor, which were 8.8 mg/dl and 48%, respectively. Since the findings were consistent with congenital deficiency of AT III, some members of her family were also examined. The concentration of AT III and its activity in the patient's son and her daughter deteriorated in a similar manner, indicating that this was a definite case of congenital deficiency of AT III. The clinical manifestations of 87 cases with congenital AT III deficiency, belonging to 24 families reported in Japan were reviewed.

Antithrombin III↗
PubMed1990

Prolymphocytic leukemia treated with natural and recombinant alpha-interferon.

The patient was a 65 year old woman with a massive splenomegaly and no lymphoadenopathy. An electron microscopic study of the peripheral blood cells revealed that these cells were prolymphocytes with a single large nucleolus. Treatment with native and recombinant alpha-interferon has produced an impressive reduction in spleen size and in the count of prolymphocytes.

Aged↗
PubMed1990

Architecture of Purkinje cells of the reeler mutant mouse observed by immunohistochemistry for the inositol 1,4,5-trisphosphate receptor protein P400.

P400 protein, which is identical to the inositol 1,4,5-trisphosphate receptor protein, is a glycoprotein closely associated with the membranes of Purkinje cells. Three types of monoclonal antibodies against P400 protein were employed for the immunohistochemical detection of Purkinje cells in the cerebellum and brainstem of the normal and reeler mouse. Purkinje cells in both types of mice were immunoreactive against anti-P400 antibodies, and the soma, dendrites, axon and even terminal boutons in the cerebellar and vestibular nuclei could be clearly visualized. In the cerebellum of the reeler mutant, the heterotopic Purkinje cells both within and below the granule cell layer were also immunopositive and could be clearly differentiated from the deep cerebellar nuclei, in which neurons were immunonegative. The molecular layer of the reeler cerebellum varied in thickness and certain parts were completely defective. The dendrites within the molecular layer extended from Purkinje cells whose cell bodies were located in the normal position, abnormally in the granule cell layer, or at the surface of the central mass. Outside the cortex of the cerebellum, ectopic Purkinje cells were demonstrated in 3 cerebellar nuclei, the cerebellar medulla and peduncle, and brainstem of the normal and reeler mouse.

Animals↗
PubMed1990

Target selection by cortical axons: alternative mechanisms to establish axonal connections in the developing brain.

We have described our studies of the development of projections from layer 5 of the rat neocortex to subcortical targets in the midbrain and hindbrain. The major points are briefly summarized here. 1. Layer-5 neurons extend a primary axon out of cortex and along a spinally directed trajectory, bypassing all of their targets in the midbrain and hindbrain. These targets are later contacted exclusively by collaterals formed by a delayed interstitial branching of the primary axon, not by growth cone bifurcation. 2. Collateral branches only form at stereotypic positions, not randomly along the length of the axon. Thus, specific cues identify branch points, and the length of the primary axon well behind its growth cone responds to these cues. 3. Layer-5 neurons in diverse areas of cortex initially develop the same basic set of collateral branches, although they will permanently retain different subsets of the initial common set. Therefore, branch cues are recognized by layer-5 neurons independent of whether the collateral projection formed is functionally appropriate for the cortical region in which the neuron resides. 4. In vitro and in vivo evidence indicates that one of the major branches, which forms the corticopontine projection, is induced and directed into its target, the basilar pons, by a diffusible, target-derived, tropic signal. Thus, a chemotropic cue promotes recognition of the basilar pontine target by the primary layer-5 axons. 5. In this system, then, target selection is not the responsibility of the growth cone of the primary axon.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1990

Observations on the structural features and characteristics of biological apatite crystals. 1. Observation on the shape and arrangement of the cross sectioned enamel crystals.

In a series of studies to investigate the structural features of biological crystals, using transmission electron microscope, the observations have been made on the shape and arrangement of the cross-sectioned crystal obtained from cross sections through the body of adult human enamel rod, in the surface layer, and in the middle and deep layers. The shapes of the cross sectioned crystals in the surface layer of the enamel are generally different from those in the middle and deep layers. In the surface layer of the enamel, the cross sectioned crystals show a considerable variation in shape and size, and have an irregular shape. The crystals are densely packed. Each crystal is adjacent to the neighboring one, and usually, the arrangement of crystals have an appearance rather like a "stone wall". In contrast, the cross sectioned enamel crystals in the middle and deep layer, are somewhat small than those in the surface layer, and have greater gaps between the crystals. In the middle and deep layers of the enamel, it is rare for the shapes of the crystals to be irregular, therefore, they retain their original shape, most of which are long and hexagonal.

Dental Enamel↗