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T Terada

Publications and source records attributed to T Terada.

At least 415 records · Page 23Linked to original sources
PubMed1989

Extrahepatic portal venous obstruction of different pathogenesis in pancreatic diseases: reports of 4 autopsy cases with chronic pancreatitis and pancreatic carcinoma.

Four autopsy cases of extrahepatic portal venous obstruction associated with pancreatic diseases, 1 case of pancreatitis and 3 cases of pancreatic carcinoma, are presented. The pathogenesis of portal obstruction was different in each case; old thrombosis with recanalization due to chronic pancreatitis with pseudocysts formation in 1 case, fresh thrombosis due to intraportal venous catheterization for pancreatic carcinoma in 1 case, fresh thrombosis probably due to pancreatitis accompanying pancreatic carcinoma in 1 case, and direct invasion of pancreatic carcinoma into the portal vein in the remaining 1 case. Morphologic evidence for portal hypertension was present in each case. In the pancreatitis case and one pancreatic carcinoma case with portal tumor invasion, both of which had chronic portal obstruction, there were many thin-walled vascular channels (cavernous transformation) around the occluded portal vein. Their endothelia were positive for factor VIII-related antigen and Ulex europaeus lectin I, implying that these vessels were hepatopetal blood vascular collaterals. It was shown that pancreatic diseases resulted in portal venous obstruction by several different mechanisms and chronic portal obstruction in pancreatic diseases led to the formation of hepatoperal blood vascular collaterals.

Adenocarcinoma↗
PubMed1989

Mallory body clustering in adenomatous hyperplasia in human cirrhotic livers: report of four cases.

We report four cases of liver cirrhosis in which seven nodules of adenomatous hyperplasia (AH) were present. Each nodule contained one to several foci of hepatocytes with Mallory bodies (MBs). All of these foci were well-circumscribed lesions located within the nodules of AH. The cells containing MBs showed variable degrees of atypia. At least two of the foci were considered to represent a recent proliferation of the cells containing MBs, possibly premalignant foci, because they showed resistance to the accumulation of stainable iron in siderotic background. From these observations, it was suggested that the MB-containing hepatocellular clusters in AH might have occurred as the result of proliferation in small foci and that at least some of them may be related to hepatocarcinogenesis in humans.

Adenoma↗
PubMed1989

Vascular plexus around intrahepatic bile ducts in normal livers and portal hypertension.

Vessels around the intrahepatic large bile ducts (peribiliary vascular plexus) were examined by histologic, immunohistochemical and scanning electron microscopic observations. The vessels within duct walls were mainly capillaries, while those around the duct walls were composed of capillaries and venules. A majority of vessels was positive for factor VIII-related antigen and Ulex europaeus lectin I. Scanning electron microscopy of hepatic arterial and biliary casts revealed that bile ducts were surrounded by the vascular plexus derived from hepatic arterial branches, and serial section observations in addition disclosed the vessels connecting the peribiliary plexus with portal venous branches ('internal roots'). The peribiliary vascular plexus was increased considerably in livers with portal hypertension, especially idiopathic portal hypertension, extrahepatic portal venous obstruction and hepatocellular carcinoma with portal venous tumor thrombi. Internal roots were also frequently found in the livers with portal hypertension. These results suggest that altered intrahepatic hemodynamics in portal hypertensive conditions involves the peribiliary vascular plexus, resulting in an increase of the number and frequent occurrence of 'internal roots', these vessels probably operating as intrahepatic collaterals.

Bile Ducts, Intrahepatic↗
PubMed1989

Innervation of intrahepatic bile ducts and peribiliary glands in normal human livers, extrahepatic biliary obstruction and hepatolithiasis. An immunohistochemical study.

Innervation of the intrahepatic biliary tree was examined in human normal livers, extrahepatic biliary obstruction and hepatolithiasis. Nerve fibers were immunohistochemically identified on formalin-fixed and paraffin-embedded sections by antibodies to S-100 protein (S-100) and neuron specific enolase (NSE). S-100 and NSE-immunoreactive nerve fibers were present in the walls of intrahepatic large, medium-sized and septal bile ducts as well as in peribiliary glands. Some nerve fibers were in close contact with epithelia of bile ducts and peribiliary glands. Serial section observations showed that the nerve fibers arising from nerve bundles approached, and came to lie in close contact with epithelia of the bile ducts and peribiliary glands. Nerve fibers were sparse around the interlobular bile ducts and bile ductules. These immunoreactive nerve fibers of the intrahepatic biliary tree were rather sparse in normal livers, intermediate in extrahepatic biliary obstruction and dense in hepatolithiasis. These findings suggest that intrahepatic bile ducts and peribiliary glands are innervated and biliary functions are regulated in part by these nerve fibers. Increased nerve fibers may have altered effects on biliary functions in hepatolithiasis.

Aged↗
PubMed1989

Inhibitory effect of 5-phosphoribosyl 1-pyrophosphate and ADP on the nonoxidative pentose phosphate pathway activity.

The rate of the conversion of ribose 5-phosphate to hexose 6-phosphates by reaction of the non-oxidative pentose phosphate pathway was measured in the presence of various biological materials. Of 22 compounds tested, PRPP and ADP markedly inhibited the formation of hexose 6-phosphates from ribose 5-phosphate. The transketolase activity in beef liver enzyme preparation was extremely inhibited by PRPP and ADP, but the transaldolase activity was not inhibited. The mode of inhibition of transketolase by PRPP and ADP was a competitive one. The Ki value for PRPP was 0.14 mM and that for ADP 0.54 mM with respect to transketolase. We discuss the possible regulatory roles of ADP and PRPP on pentose phosphate metabolism in the pentose phosphate pathway.

Adenosine Diphosphate↗
PubMed1989

Small hepatocellular carcinoma presenting as intrabiliary pedunculated polyp and obstructive jaundice.

A rare autopsy case of small hepatocellular carcinoma presenting as an intrabiliary pedunculated mass is reported. The patient, 60-year-old man, presented with obstructive jaundice and died 1 month later. At autopsy, an intrabiliary pedunculated tumor measuring 3.5 x 2.0 x 2.0 cm was found in the hepatic, right hepatic, and right posterior segmental bile ducts. The intraductal tumor was attached to the segmental bile ductal wall, where a tumor measuring 2.0 x 0.9 cm was found in the parenchyma. The parenchymal tumor was continuous with the intrabiliary mass. Histologically, the tumor was a hepatocellular carcinoma showing acidophilic granular cytoplasm with occasional hyaline globules and was structurally arranged in a vague trabecular pattern. Immunohistochemically, tumor cells were positive for alpha-fetoprotein and alpha 1-antitrypsin, but was negative for keratin. We present a brief review of the literature of such icteric hepatocellular carcinomas.

Bile Duct Neoplasms↗
PubMed1989

Epithelioid hemangioendothelioma of the liver in primary biliary cirrhosis. A case report.

We report a case of primary epithelioid hemangioendothelioma of the liver occurring in a patient with primary biliary cirrhosis, stage III. The hepatic tumor was found incidentally by imaging techniques and was surgically resected under a tentative diagnosis of metastatic carcinoma. The resected tumor (1.8 x 1.6 cm) showed typical histologic features of epithelioid hemangioendothelioma. The tumor cells were positive for factor VIII-related antigen and were stained with Ulex europaeus lectin I. Ultrastructurally, the tumor cells showed cytoplasmic vacuoles, tight junctions, basal lamina, pinocytotic vesicles, bundles of thin filaments (approximately 10 nm in diameter) and Weibel-Palade bodies. The non-tumorous part of the liver showed features of primary biliary cirrhosis, stage III. This is the first reported case of epithelioid hemangioendothelioma occurring in a liver with primary biliary cirrhosis.

Aged↗
PubMed1989

Development of cavernous vasculatures in livers with hepatocellular carcinoma. An autopsy study.

The incidence and morphology of cavernous vasculatures in livers with hepatocellular carcinoma were examined. These vasculatures were grossly or microscopically found in 64% of 102 autopsied livers with hepatocellular carcinoma, though the incidence of grossly visible vasculatures was only 7%. These vasculatures were preferentially found within the portal tracts in the vicinity of portal veins obstructed by tumor emboli, especially in the cases with marked tumor emboli of the portal venous system. A majority of these vasculatures showed histochemical and immunohistochemical characteristics of blood vessels. Our findings suggest that these vasculatures frequently develop as collaterals of portal veins obstructed by the tumor emboli in hepatocellular carcinoma.

Carcinoma, Hepatocellular↗
PubMed1989

Adenomatous hyperplastic nodules in the cirrhotic liver: differentiation from hepatocellular carcinoma with MR imaging.

Differentiation of hepatocellular carcinomas from adenomatous hyperplastic nodules (AHNs) is important for the early and precise detection of hepatocellular carcinoma in the cirrhotic liver. For this purpose, the authors compared findings on magnetic resonance (MR) images of surgically resected AHNs (n = 7) with those of hepatocellular carcinoma (n = 47). AHNs were divided into two histologic groups: those without atypia (n = 5) and those with atypical hepatocytes or malignant foci (n = 2). All AHNs without atypia were hyperintense on T1-weighted spin-echo images and hypointense on T2-weighted spin-echo images relative to the surrounding liver. However, almost all hepatocellular carcinomas, except for two lesions with massive coagulation necrosis, were demonstrated as hyperintense on T2-weighted images. MR imaging may be useful in the differentiation of AHN without atypia from hepatocellular carcinoma in the cirrhotic liver.

Carcinoma, Hepatocellular↗
PubMed1989

Comparison of dynamic and xenon computed tomography in the evaluation of cerebrovascular ischemia.

Dynamic computed tomographic (DCT) scans with iodine contrast enhancement were compared with simultaneously obtained xenon CT studies of cerebral blood flow (CBF) in 15 patients with subacute or chronic cerebrovascular ischemic disease. Specifically, the width and corrected first moment (cMT1), as demonstrated by DCT, were compared with the regional CBF (rCBF) data and the rCBF map obtained with xenon CT. The DCT and rCBF images were well correlated in patients without, but poorly correlated in those with, leptomeningeal anastomotic collateral circulation. The correlation of rCBF and 1/width with 1/cMT1 was significant (r = 0.78, p less than 0.01) in the former, but not in the latter. These data were thought to reflect a difference in the tracer inflow pattern between the patients with and those without leptomeningeal anastomoses. Our series did not include patients with acute cerebral infarction or recanalization, which are thought to be associated with marked changes in cerebral blood volume in the affected region. However, the influence of cerebral blood volume should be studied in detail in our subacute or chronic series.

Brain Ischemia↗
PubMed1989

Arterial-venous concentration gradient as a potential source of error in pharmacokinetic studies. Plasma concentration differences of 6-chloro-2-pyridylmethyl nitrate on constant infusion to rats.

1. Plasma concentrations of 6-chloro-2-pyridylmethyl nitrate (CPMN) at different sampling sites in the circulation were determined during and after constant infusion in the rat. 2. An arterial-venous CPMN concentration gradient was found and characterized by the following trends. During CPMN infusion into the right atrium, plasma concentrations were higher in arterial (aortic arch) than venous (inferior vena cava) plasma. After cessation of infusion the venous plasma concentrations were significantly higher (P less than 0.05) than those in arterial samples. There was a low concentration gradient between the right atrium and the peripheral artery, but substantial difference between the peripheral artery and the vein. There was a 1.8-2.4 extraction ratio of CPMN across the arterial-venous bed.

Animals↗
PubMed1989

Testosterone replacement therapy and prostate/seminal vesicle volume in Klinefelter's syndrome.

Volume of prostate and seminal vesicles was measured in patients with Klinefelter's syndrome by means of transrectal ultrasonography before and after testosterone replacement therapy. Continuous suppression of plasma gonadotropin levels was not observed, and plasma levels of testosterone did not maintain the normal range. However, volume of prostate (p less than 0.001) and seminal vesicles (p less than 0.05) increased significantly after testosterone replacement therapy. Volume determination of prostate and seminal vesicles by means of transrectal ultrasonography is an available parameter for evaluating the adequacy of testosterone replacement therapy in Klinefelter's syndrome.

Adult↗
PubMed1989

[Clinical study on sweep-frequency tympanometry--data analysis using principal component analysis].

A sweep-frequency tympanometer has been developed to diagnose auditory ossicular lesions more precisely. This device measures acoustic middle ear features by changing the probe tone frequency continuously. The oscillator sweeps frequency of the probe tone from 200 to 2,500Hz 1.5 seconds. A microphone picks up the changes in the acoustic pressure and the phase in the external auditory meatus during the frequency change of the probe tone. These measurements are performed under pressures at -200 and 0 dapa, and differences of both the acoustic pressure and the phase between these two pressures are graphically displayed using a microcomputer. This device can also measure and digitally display the frequency (BHz) and the sound pressure (BdB) at the minimum point (B) of the sound pressure curve, the frequency (ZHz) at 0 crossing point (Z) of the sound pressure curve, and the frequency (PHz) and the phase difference (Pdeg) at the maximum point (P) of the phase curve. Normal ranges of these five values were obtained to establish diagnostic criteria from 200 normal ears. The normal values were as follows: BHz, 480 to 1,070Hz; BdB, -6.0 to -1.8dB; ZHz, 1,100 to 1,860Hz; PHz, 910 to 1,820Hz; and Pdeg, 16.3 to 47.9 degrees. Eight cases of ossicular dislocation and 14 cases of ossicular fixation, all of which had normal external auditory meatus and tympanic membrane, were evaluated based on these values. All the cases with ossicular dislocation and 12 cases out of 14 with ossicular fixation were correctly diagnosed.(ABSTRACT TRUNCATED AT 250 WORDS)

Acoustic Impedance Tests↗
PubMed1989

Macroregenerative nodules of the liver in primary biliary cirrhosis: report of two autopsy cases.

Recently, macroregenerative nodules of the liver have been regarded as putative precancerous lesions in human cirrhotic livers. We describe the morphologies of two macroregenerative nodules, one benign and another harboring a malignant hepatocellular focus, occurring in two patients with primary biliary cirrhosis, both at the cirrhotic stage. The macroregenerative nodules of both patients were found incidentally at autopsy. The macroregenerative nodule of case 1 (42-yr-old female) was composed of hyperplastic hepatocytes with little atypia. The macroregenerative nodule of case 2 (67-yr-old male) had a malignant focus, in addition to atypical hepatocytes. The atypical hepatocytes showed mild nuclear crowding, slightly increased nucleocytoplasmic ratio, and mild nuclear hyperchromasia. The malignant focus was free of stainable iron against the mildly siderotic background. These findings may support the concept that macroregenerative nodules can also be a preneoplastic lesion in primary biliary cirrhosis.

Adult↗
PubMed1989

Intrahepatic cholesterol stones associated with peripheral cholangiocellular carcinoma: an autopsy case.

A rare autopsy case of intrahepatic cholesterol stones associated with peripheral intrahepatic cholangiocellular carcinoma is presented. The patient, a 60-yr-old man, was diagnosed as having peritoneal dissemination of adenocarcinoma, and died of respiratory failure 4 months later. At autopsy, intrahepatic cholangiocellular carcinoma was found at the left lateral segment of the liver. The cancer was extensively disseminated to the peritoneal cavity. In addition, the liver harbored a cholesterol stone (1.0 cm in diameter) impacted in the right peripheral bile duct, as well as tiny cholesterol stones (0.1-0.2 cm in diameter) scattered in the intrahepatic peripheral bile ducts. A few tiny cholesterol stones were also present in the cancerous bile ducts. Although the causal relationship between the intrahepatic cholesterol stones and cholangiocellular carcinoma remains speculative, clinicians should be aware of this association.

Adenoma, Bile Duct↗