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Biomedical subjects

T Tashiro

Publications and source records attributed to T Tashiro.

At least 361 records · Page 20Linked to original sources
PubMed1985

[Changes of whole body protein turnover due to the severity of surgical stress].

This study was conducted to understand the mechanisms underlying the loss of body nitrogen after surgical trauma. Thirteen patients who underwent moderate to severe abdominal surgery and six for control were studied. The measurement of whole body protein turnover was made on the third and tenth postoperative day during isonitrogenous and isocaloric TPN using the constant infusion method of [15N] glycine. Nitrogen balance was improved markedly in 6 patients, who received moderate surgical procedures (group I). However the balance was still negative at the tenth postoperative day in 7 patients, who received severe surgery with some critical complications (group II). A significant increase in whole body protein breakdown on the third postoperative day in groups I and II were found (p less than 0.02, p less than 0.001, respectively). Breakdown was higher in group II than in group I (p less than 0.02). Whole body protein synthesis tended to increase on the third postoperative day in group II, but was within the normal range in group I. In conclusion, the change of whole body protein turnover was different depending upon the severity of stress. Protein synthesis unchanged in moderate stress, but tended to increase in severe stress with a greater increase of breakdown.

Adult↗
PubMed1984

Ascending projections from the nucleus of the brachium of the inferior colliculus in the cat.

Ascending projections from the nucleus of the brachium of the inferior colliculus (NBIC) in the cat were studied by the autoradiographic tracing method. Many fibers from the NBIC ascend ipsilaterally in the lateral tegmentum along the medial border of the brachium of the inferior colliculus. At midbrain levels, fibers from the NBIC end in the superior colliculus, the pretectum, the central gray and the peripeduncular tegmental region bilaterally with ipsilateral predominance. NBIC fibers to the superior colliculus are distributed densely to laminae VI and III throughout the whole rostrocaudal extent of the colliculus. In the pretectum, NBIC fibers terminate in the anterior and medial nuclei and the nucleus of the posterior commissure. NBIC fibers to the dorsal thalamus are distributed largely ipsilaterally. Many NBIC fibers end in the dorsal and medial divisions of the medial geniculate body, but few in the ventral division. The NBIC also sends fibers to the suprageniculate, limitans and lateralis posterior nuclei and the lateral portion of the posterior nuclear complex; these regions of termination of NBIC fibers constitute, as a whole, a single NBIC recipient sector. Additionally, the NBIC sends fibers to the centralis lateralis, medialis dorsalis, paraventricular and subparafascicular nuclei of the thalamus.

Afferent Pathways↗
PubMed1984

Soma size comparison of the trigeminal ganglion cells giving rise to the ascending and descending tracts: a horseradish peroxidase study in the cat.

Soma size was compared between the trigeminal ganglion cells projecting to the main sensory trigeminal nucleus (Vs) and those projecting to the nucleus caudalis (Vc) of the spinal trigeminal nucleus in the cat after injection of horseradish peroxidase (HRP) into each nucleus. The results showed that the cells projecting to the Vc (Vc cells) contained by far a greater percentage of small cells than do those projecting to the Vs (Vs cells). In the Vc case, about one-half the total number of measured labeled cells were the smallest with a diameter less than 36 microns, whereas in the Vs cases, only a small proportion of the total number of measured labeled cells were that small. In addition, the results also made it clear that the Vs cells in the ophthalmic and maxillary divisions contained a higher percentage of larger cells than those in the mandibular division.

Animals↗
PubMed1984

Synthesis and antitumor activity of tropolone derivatives.

Treatment of tropolones with benzaldehyde diethyl acetals gave monotropolone (12) and bistropolone (13) derivatives at the benzylic position, whereas the related 1-ethoxyisochroman and the diethyl acetals of crotonaldehyde and cinnamaldehyde gave only the monotropolone derivatives (5, 10, or 11). The monotropolone derivatives (5, 10, 11, and 12) had poor potency against P388 leukemia in mice, but the bistropolone derivatives (13 and 14) showed significant potency and prolongation of life.

Animals↗
PubMed1984

Two populations of axonally transported tubulin differentiated by their interactions with neurofilaments.

In the sensory fibers of the rat sciatic nerve (fibers of the dorsal root ganglion cells), two components of tubulin transport were observed that differed in the rate of transport, solubility in Triton, and subunit composition. The faster component, migrating ahead of the neurofilament proteins, was soluble in 1% Triton. The slower component, migrating with the neurofilament proteins, was insoluble in 1% Triton and contained a unique polypeptide, "NAP," in the tubulin region that was not present in the faster component. "NAP" was not a subspecies of tubulin as evidenced by peptide mapping. It seems to be a neurofilament-associated protein. When a complete separation of the main tubulin wave from the neurofilament wave was achieved in the motor axons of the same nerve (axons of the ventral motoneurons) under the effect of beta,beta'-iminodipropionitrile, a portion of tubulin was still found associated with the retarded neurofilament wave. The subunit composition of this portion was similar to the slower, neurofilament-associated component in the sensory fibers under normal conditions, i.e., enriched in "NAP" and the most acidic subtype of beta-tubulin. It is suggested that two populations of transported tubulin exist that are differentiated by the extent of their interaction with neurofilaments.

Animals↗