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Biomedical subjects

T Tanino

Publications and source records attributed to T Tanino.

At least 73 records · Page 4Linked to original sources
PubMed1987

Paradoxical antibacterial activity of cefmenoxime against Proteus vulgaris.

The growth-inhibitory effect of cefmenoxime against Proteus vulgaris was studied by using the broth dilution and paper disk diffusion methods. Cefmenoxime showed growth-inhibitory activity against Proteus vulgaris at low concentrations but not at high concentrations up to a certain limit. This paradoxical antibacterial activity was not observed with cefoperazone and cefbuperazone. The induction of beta-lactamase by cefmenoxime and the rate of hydrolysis of cefmenoxime in the culture broth were proportional to the initial concentration of this antibiotic. At high initial concentrations, cefmenoxime was rapidly inactivated. On the other hand, neither cefoperazone nor cefbuperazone was inactivated irrespective of concentration. We conclude that cefmenoxime induces beta-lactamase in P. vulgaris, perhaps accounting for its paradoxical antibacterial effect.

Cefmenoxime↗
PubMed1986

Electrophysiological findings in a family with congenital arteriohepatic dysplasia (Alagille syndrome).

Arteriohepatic dysplasia (Alagille syndrome) is a congenital cholestatic disease associated with ocular abnormalities. Three Japanese siblings, a 14-year-old girl, an 11-year-old boy, and a 9-year-old girl with this syndrome were studied. All three patients showed neonatal jaundice, hepatic dysfunction, characteristic facies, and psychomental retardation. The two sisters had cardiac murmurs. Ophthalmological examinations revealed that they had posterior embryotoxon, refractive error, retinochorodial degeneration, and electrophysiological abnormalities. The two sisters showed retinochoroidal degeneration and unilateral high myopia while the brother showed marked retinochoroidal degeneration with extensive pigment clumps. Visual fields showed moderate concentric contraction in the two sisters and marked concentric contraction in the brother. Amplitudes of the single flash electroretinogram were moderately reduced in the sisters, the test was nonrecordable in one eye and extensively reduced in the other eye of the brother. The electrooculogram was borderline in the elder sister and abnormal in the brother and younger sister. Visual evoked cortical potential (VECP) were abnormal in the high myopic eye in each of the two sisters. Ophthalmological findings including electrophysiological examinations may help to confirm the diagnosis of this multisystem familial disorder.

Adolescent↗
PubMed1986

Objective evaluation of binocular function with pattern reversal VER. III. Effect of stimulus size and localization.

The effect of central and peripheral stimulus field on monocular and binocular amplitude and binocular summation of the pattern reversal VER were investigated. When the central stimulus field size was smaller than 2.0 degrees X 2.0 degrees, there was no significant difference between the amplitudes of the monocular and binocular VER, but when it was equal to or larger than 2.4 degrees, the binocular VER amplitude was significantly larger than the monocular. The value of the binocular summation was highest at the central stimulus field size of 4.0 degrees X 4.0 degrees; at larger sizes, there were no significant changes in the value. Use of a central stimulus field size larger than 2.4 degrees X 2.4 degrees was therefore considered a prerequisite for the effective assessment of visual function, especially binocular function using the pattern reversal VER. Regarding the effect of peripheral stimulus field, both the monocular and binocular VER, but particularly the latter, were found to be sensitive to the central scotoma produced by covering the center of the full-field stimulus. The value of the binocular summation showed a significant reduction with the small central scotoma. We concluded that the pattern reversal VER is very sensitive to a central scotoma and that binocular function is mediated mainly through the central part of the stimulus field.

Adult↗
PubMed1986

Objective evaluation of binocular function using the pattern reversal visual evoked response. II. Effect of mean luminosity.

The effect of mean luminosity change on pattern reversal visual evoked response (VER), especially monocular VER, binocular VER and binocular summation, was studied. The mean luminosity level was changed with the use of neutral density filters. When mean luminosity level was decreased binocularly, binocular and monocular VER amplitudes decreased and binocular summation increased, reaching its peak at a luminosity of -0.3 log foot-lambert. When mean luminosity was changed monocularly and the interocular luminosity difference was larger than 0.6 log unit, the binocular VER became almost equal to or smaller than the monocular VER. In dim luminosity, the binocular system functioned better than the monocular system. Even a slight luminosity difference between the two eyes could disturb the binocular system.

Adult↗
PubMed1986

The antibacterial activity of ticarcillin/clavulanic acid (BRL28500) against ticarcillin-resistant bacteria.

The efficacy of BRL28500, a formulation of ticarcillin (TIPC, 15 parts) and clavulanic acid (CVA, 1 part), against TIPC-resistant strains of Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae was studied both in vitro and in vivo. The MICs of BRL28500 against these beta-lactamase producing strains were lower than those of TIPC or CVA alone against such strains. When BRL28500 was added during the logarithmic growth phase of bacteria at a concentration equivalent to the MIC, it demonstrated marked lytic activity. Cells treated with BRL28500 underwent morphological change, becoming filament-like, similar to those treated with TIPC alone. With CVA alone at concentrations above the MIC the cells assumed a stable round form. In bacterial cultures of the beta-lactamase-producing strains, TIPC was protected from hydrolysis by the presence of CVA. The in vivo activity of BRL28500 against experimental infections in mice caused by beta-lactamase-producing strains of bacteria was superior to that of TIPC alone. TIPC and CVA were found to be well distributed in peritoneal fluid following subcutaneous administration of BRL28500 into mice with peritoneal infections. The residual TIPC concentrations achieved were higher than when TIPC alone was administered. These results suggest that BRL28500 will be effective in the treatment of human infections due to TIPC-resistant bacteria.

Animals↗
PubMed1986

[In vitro susceptibility of bacterial isolates from patients with respiratory tract infections to beta-lactam antibiotics].

In vitro susceptibilities of bacterial pathogens to beta-lactam antibiotics were determined. Bacterial pathogens examined included various isolates from the patients of respiratory tract infections at the hospitals of Kyoto-Shiga area in 1981 and 1983. Major organisms isolated from clinical specimens were Haemophilus spp., Klebsiella spp., Pseudomonas spp., S. aureus and Streptococcus spp. An increase in the isolation frequency of P. aeruginosa, a decrease in the isolation frequency of H. influenzae and no change in the isolation frequency of the other organisms were observed between the years 1981 and 1983. Data from susceptibility tests of clinical isolates confirmed that cefazolin (CEZ) and cefotiam (CTM) showed good antibacterial activity against S. aureus and cefmenoxime (CMX) was highly effective on Streptococcus spp., but that the susceptibilities of both organisms to CEZ, CTM, and cefmetazole (CMZ) in 1983 were lower than in 1981. Although CMX also showed good antibacterial activity against Klebsiella spp., there were no changes in the effectiveness of CTM, CMZ, and CEZ between the years 1981 and 1983. The in vitro antibacterial activities of CMX and cefoperazone against Haemophilus spp. were superior to those of the other beta-lactams tested, but there was a decline in the efficacy for CEZ. Although cefsulodin and piperacillin were highly active against Pseudomonas spp., declines in their effectiveness was observed between the years 1981 and 1983.

Adolescent↗
PubMed1986

[In vitro susceptibility, of bacterial isolates from patients with respiratory tract infections, to beta-lactam antibiotics II].

In vitro susceptibilities of bacterial pathogens to beta-lactam antibiotics were determined. Bacterial pathogens examined included various isolates from patients of respiratory tract infections at hospitals of Kyoto-Shiga area in 1984. Major organisms isolated from clinical specimens were Pseudomonas spp., Klebsiella spp., Haemophilus spp., Staphylococcus aureus and Streptococcus spp. An increase in the isolation frequency of Pseudomonas spp., a decrease in the isolation frequency of S. aureus, and no change in the isolation frequency of other organisms were observed between the years 1981, 1983 and 1984. Data from susceptibility tests of clinical isolates confirmed that cefazolin (CEZ), cefamandole and cefotiam (CTM) showed good antibacterial activity against S. aureus and cefmenoxime (CMX) was highly active against Streptococcus spp., but their susceptibilities to CEZ in 1984 were lower than in 1983. Susceptibilities of Klebsiella spp. to CMX, cefbuperazone, latamoxef, CTM, cefoperazone (CPZ) were better than those to other beta-lactam antibiotics tested, but there was a decline in the susceptibility to CEZ, cefmetazole and CTM. Further, CMX, CPZ and LMOX also showed good antibacterial activity against Haemophilus spp. Although gentamicin, cefsulodin, cefpiramide and piperacillin were highly active against Pseudomonas spp., resistant organisms were present for all the beta-lactam antibiotics tested.

Anti-Bacterial Agents↗
PubMed1986

Regressor serum factor-dependent nonspecific killers in tumor-bearing mice.

Spleen cells obtained from C3H/He or C57BL/6 mice bearing syngeneic ascitic tumor cells in the early stage of tumor progression had activity to lyse various tumor cells in vitro when serum from MM2-regressor C3H/He was added to the reaction mixture. The serum component responsible for the reaction was of non-immunoglobulin nature. The serum factor-dependent cytotoxic cells were Thy-1-positive cells which were not adherent to nylon wool or Sephadex G-10 and were not natural killer cells. Allogeneic tumor cells and syngeneic tumor cells of near-tetraploid chromosomes were susceptible to such lysis whereas syngeneic near-diploid cells were resistant. The serum factor was absorbed by susceptible cells and not by resistant cells.

Animals↗
PubMed1986

Effect of aniseikonia on binocular function.

The pattern reversal visual evoked response (VER) was recorded under conditions of artificially unbalanced visual input between two eyes, an aniseikonia induced by size lenses that alter the perceived retinal image size without changing refraction. At 3.0% aniseikonia binocular summation started to decrease, and at 5.0% aniseikonia there was no significant binocular summation. In higher aniseikonia (8.0-10.0%), binocular inhibition replaced binocular summation. The phase difference between binocular and monocular VER was largest at zero aniseikonia. When aniseikonia exceeded 5.0%, there was no significant phase difference between the two recording conditions. These results suggested that the binocular system can compensate for up to a 3.0% difference in perceived retinal image size (aniseikonia), but in higher aniseikonia the binocular system can no longer compensate for the difference and binocular inhibition takes place. These findings agree with previously reported subjective and psychophysical results. The authors suggest that this objective method of evaluation using the pattern reversal VER may be helpful in pediatric ophthalmology when subjective methods are of limited use.

Adult↗
PubMed1985

Electrophysiological similarities between two eyes with X-linked recessive retinoschisis.

Electroretinograms (ERG) and electro-oculograms (EOG) were studied in 88 eyes of 44 male patients with X-linked recessive retinoschisis. Differences of fundus appearance, ERG, and EOG between the eyes of each patient were analyzed. Fundus abnormalities were symmetrical in 77.3% of the cases. The amplitude of the ERG a-wave was normal in 26.1% and was abnormally low in 73.9%. The amplitude of the b-wave was below normal in all eyes; thus a small b-wave/a-wave ratio, which is characteristic of X-linked recessive retinoschisis, was observed in every case. The light peak to dark trough (LP/DT) ratio of the EOG was normal in 90.8% of the cases. The relative electrophysiological differences between the two eyes were calculated and showed that a-wave amplitude was not different between eyes in 75.0% of the cases; b-wave amplitude was not different in 77.3% of the cases; b-wave/a-wave ratio was symmetrical in 93.2% of the cases; and the LP/DT ratio was consistent between eyes in 86.8% of the cases. These results suggest that in most cases of X-linked recessive retinoschisis the fundus appearance, ERG, and EOG are similarly affected in both eyes of the patient.

Adolescent↗
PubMed1985

Measurement of contrast sensitivity function using pattern-reversal visual evoked responses.

In order to determine whether pattern-reversal visual evoked response (VER) can be used to measure contrast sensitivity function (CSF), we investigated the effect of change of contrast upon pattern-reversal VER. Contrast thresholds for VER were extrapolated in five spatial frequencies. The CSF curve obtained from the VER showed the inverted U-shape as the psychophysical CSF curve. However, the low frequency fall-off that is usually seen in psychophysical CSF was less evident in the electrophysiological CSF. The difference between the electrophysiological CSF and the psychophysical CSF increased along with the spatial frequency. Proper stimulus conditions would make this method of evaluation of CSF by pattern reversal VER useful in relatively young children in whom psychophysical tests cannot be performed.

Adult↗