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Biomedical subjects

T Takeuchi

Publications and source records attributed to T Takeuchi.

At least 1,801 records · Page 100Linked to original sources
PubMed1984

[Changes in urinary adrenaline and noradrenaline and plasma cortisol concentrations during labor and delivery].

Urinary adrenaline and noradrenaline concentrations were determined at 38-41 wks of gestation, admission for the onset of labor, 4 hrs after admission and at the cervical dilatation of 8-10 cm, immediately after delivery and on the next morning. Both catecholamine concentrations rose remarkably at the dilatation of 8-10 cm and were found to be still high immediately after delivery. The rise in adrenaline concentrations was much greater than noradrenaline. On the morning after delivery, the adrenaline concentrations fell significantly but noradrenaline remained high. The time-course of urinary catecholamines was similar to that of plasma reported by others. Serum cortisol concentrations rose significantly during labor and delivery but returned to the concentrations of 38-41 wks of gestation by the next morning. The present time course of adrenaline, noradrenaline and cortisol levels in urine or serum during labor, delivery and puerperium suggests that these hypersecretion may be due to emotional, physical and painful stress, respectively, considering literatures.

Epinephrine↗
PubMed1984

A case report of renal pelvic squamous cell carcinoma.

We describe a case of a 75-year-old woman with squamous cell carcinoma in the right renal pelvis accompanied by multiple dysplasia in the upper urinary tract. Though it is difficult to make a preoperative diagnosis of squamous cell carcinoma, lavage cytology is particularly valuable. Renal arteriography and cross-sectional imaging are also useful to assess an accurate stage. We postulate that severe dysplasia could be a precursor of squamous cell carcinoma as well as transitional cell carcinoma.

Aged↗
PubMed1983

Analysis of bile acids by micro high-performance liquid chromatography with postcolumn enzyme reaction and fluorometric detection.

Free and conjugated bile acids in human sera were analyzed by micro high-performance liquid chromatography with detection by an immobilized hydroxysteroid dehydrogenase postcolumn reaction and a spectrofluorometer. Bile acids could be effectively collected on a precolumn, 10 X 0.2 mm I.D., packed with silica-ODS (octadecylsilane), by passing a dilute phosphate solution of a serum through it. The detection limit was 0.13-0.28 pmole for a single-to-noise ratio of 2. An amount of 0.1 ml of serum was enough for analysing each bile acid in it.

3-Hydroxysteroid Dehydrogenases↗
PubMed1983

Median raphe- and contralateral hippocampus-elicited EEG spikes which correspond to hyperpolarizations of pyramidal cells in the kindled hippocampus of the rabbit.

Rabbit hippocampus was chronically stimulated with implanted electrodes until interictal EEG spikes were kindled in it. The kindled hippocampus was then studied in acute experiments. Stimulation of the median raphe nucleus and that of the opposite hippocampus produced EEG spikes, whose intracellular correlates were hyperpolarizations of pyramidal cells (referred to as inhibitory EEG spikes).

Animals↗
PubMed1983

Inhibition of brain prostaglandin D synthetase and prostaglandin D2 dehydrogenase by some saturated and unsaturated fatty acids.

The activities of rat brain prostaglandin D synthetase and swine brain prostaglandin D2 dehydrogenase were inhibited by some saturated and unsaturated fatty acids. Myristic acid was most potent among saturated straight-chain fatty acids so far tested. The IC50 values of this acid were 80 microM for prostaglandin D synthetase and 7 microM for prostaglandin D2 dehydrogenase, respectively. Little inhibition was found with methyl myristate and myristyl alcohol. The IC50 values of these derivatives were more than 200 microM for both enzymes, suggesting that the free carboxyl group was essential for the inhibition. The effects of cis double bond structure of fatty acids on the inhibition potency were examined by the use of the carbon 18 and 20 fatty acids. The inhibition potencies for both enzymes increased with the number of cis double bonds; the IC50 values of stearic, oleic, linoleic and linolenic acid were, respectively, more than 200, 60, 30 and 30 microM for prostaglandin D synthetase, and 20, 10, 8.5 and 7 microM for prostaglandin D2 dehydrogenase. Arachidonic acid also inhibited the activities of both enzymes with respective IC50 values of 40 microM for prostaglandin D synthetase and 3.9 microM for prostaglandin D2 dehydrogenase, while arachidic acid showed little inhibition. The kinetic studies with myristic acid and arachidonic acid demonstrated that the inhibition by these fatty acids was competitive and reversible for both enzymes. Myristic acid and other fatty acids also inhibited the activities of several enzymes in prostaglandin metabolism, although to a lesser extent. The IC50 values of myristic acid for prostaglandin E isomerase, thromboxane synthetase and NAD-linked prostaglandin dehydrogenase (type I) were 200, 700 and 100 microM, respectively. However, this fatty acid showed little inhibition on fatty acid cyclooxygenase (20% at 800 microM), glutathione-requiring prostaglandin D synthetase from rat spleen (20% at 800 microM), and NADP-linked prostaglandin dehydrogenase (type II) (no inhibition at 200 microM).

Animals↗
PubMed1983

Micro high-performance liquid chromatographic separations of bile acids.

Separations of bile acids by micro high-performance liquid chromatography (micro-HPLC) using an immobilized 3 alpha-hydroxysteroid dehydrogenase post-column and a spectrofluorimeter are described. The sensitivity of detection is greatly increased by pre-mixing beta-nicotinamide adenine dinucleotide with the mobile phase, using a single pump. The detection limit is 0.04-0.7 ng, depending on the solute. Instruments suitable for the analysis of bile acids in micro-HPLC are discussed.

Bile Acids and Salts↗
PubMed1983

Inhibition of histidine decarboxylase and tumour promoter-induced arachidonic acid release by lecanoric acid analogues.

Lecanoric acid analogues containing benzanilide structure inhibited histidine decarboxylase and arachidonic acid release from the cell membrane phospholipids induced by a tumour promoter, 12-O-tetradecanoylphorbol-13-acetate. But they did not inhibit cellular binding of phorbol-12,13-dibutylate. Lecanoric acid analogues also inhibited prostaglandin synthetase and delayed-type hypersensitivity responses against sheep red blood cells in mice. Thus, lecanoric acid analogues antagonized several enzymic and cellular effects of the tumour promoter.

Animals↗
PubMed1983

Evaluation of serum prostate-specific antigen in urologic cancers.

Serum prostate-specific antigen (PA), a new tumor marker of prostate cancer, was evaluated with an eznyme immunoassay (EIA) in various urologic cancer patients and benign prostatic diseases in Japanese. Sera of prostate cancer patients before treatment (n = 27) revealed a range of PA concentrations from 0.12-23 ng/ml with a mean (+/- SD) of 5.78 +/- 6.85 ng/ml, while that of patients with benign prostatic hypertrophy (BPH) (n = 27) showed from less than 0.10 to 2.6 ng/ml with 0.84 +/- 0.81 ng/ml (mean +/- SD). The mean serum PA levels in nonprostatic cancers were calculated as follows: bladder cancer (n - 21), 0.77 +/- 0.55 ng/ml; renal pelvis or ureteral cancer (n = 6), 0.46 +/- 0.47 ng/ml; renal adenocarcinoma (n equal to 6), 1.07 +/- 0.77 ng/ml; other urologic cancers (n = 6), 0.55 +/- 0.52 ng/ml. Serum PA ranged from less than 0.10 to 1.1 ng/ml in patients with prostatitis (n = 5). A significant statistical difference in serum PA levels between prostate cancer and other groups was recognized. These results suggested that an elevation of serum PA value was highly specific to prostate cancer in urological malignancies. The evaluation of serum PA may be of great value in the detection of prostate cancer.

Adenocarcinoma↗
PubMed1983

Elevated immunoglobulin M levels in low birth-weight neonates with chronic respiratory insufficiency.

Ten babies weighing less than 1500 g at birth subsequently developed chronic respiratory insufficiency and bubbly appearance on chest X-ray during their infancy. The clinical diagnoses were compatible with Wilson-Mikity syndrome. They were compared with very low birth-weight infants who did not show these signs and symptoms. On the first day (mean) of life significantly high serum immunoglobulin M levels were found in the study group. The possibility exists that the chronic respiratory insufficiency seen in these very low birth-weight infants may have been caused by intrauterine infection.

Female↗
PubMed1983

Electroencephalographic study of intraventricular hemorrhage in the preterm newborn.

The neonatal EEG was studied in 19 preterm infants with peri- and intraventricular hemorrhage (IVH) verified by CT scan. The background EEG showed an increasing discontinuity with increasing severity of brain damage. The EEG was of little diagnostic value but provided a good prognostic tool. The degree of brain damage classified by background EEG was significantly correlated with clinical outcome, but the degree of hemorrhage graded by CT scan was of less prognostic value. Positive rolandic sharp waves were seen in only 2 of 19 infants and were of little diagnostic significance. The EEG was also useful to detect subtle seizures including apneic ones in very low-birthweight infants with IVH.

Apnea↗

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