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Biomedical subjects

T Takemoto

Publications and source records attributed to T Takemoto.

At least 217 records · Page 12Linked to original sources
PubMed1981

Advance of endoscopy.

Recent endoscopy has made startling progress. Consequently, now endoscopists can diagnose minute (or micro) cancer less than 5 mm in diameter in the digestive organs, particularly in the stomach and the colon. However, early detection of esophageal, biliary tract, or pancreatic cancer is still insufficient in spite of application of a new apparatus or subsidiary method. Among them, regarding recent increment of the cases with pancreatic cancer, it is absolutely necessary for the improvement of a prognosis to reveal small cancer less than 2 cm in diameter, endoscopically. Usefulness of laparoscopy for the diagnosis of hepatocellular cancer is less as compared with hepatic angiography. In this paper, we summarize the present status of gastro-enterological endoscopy in Japan and point clearly the issue to solve in the future.

Aged↗
PubMed1980

Complication of laparoscopy in Japan.

Trends of examinees and complications of laparoscopy were examined by a questionaire sent to all representative institutions in Japan. As a conclusion, the rate of complication by this examination was 10 times higher, while its mortality was 25 times higher, as compared with gastroenterological endoscopic examination. This article may indicate the present status of laparoscopy in Japan.

Adult↗
PubMed1980

Peritoneoscopic findings and liver function in chronic liver disease.

In 100 cases with chronic liver disease, peritoneoscopy and liver biopsy were performed, and the association between peritoneoscopic findings and liver function was studied. With respect to liver function, a series of tests which seem to indicate residual liver function were selected as follows; dye excretion, serum levels of albumin and cholinesterase, and subfractions of serum proteins. In evaluating the periotoneoscopic view, new criteria for the classification of liver surface findings are proposed. All cases were divided into 5 types in accordance with these criteria. Analysis of the correlation between peritoneoscopic findings and liver function showed that the degree of liver dysfunction was clearly indicated by liver surface alterations. As a result, the residual liver function may be determined quite well by using this classification.

Biopsy↗
PubMed1980

Application of the methylene blue staining method to the study of experimentally PNNG-induced intestinal metaplasia of the canine stomach.

To elucidate the developmental process of the intestinal metaplasia of the stomach, PNNG was orally administered to dogs and the sequential endoscopic examination was performed by using the methylene blue staining method. In the early period of the drug administration dogs showed the findings of erosive gastritis at the antral portion. In the 42nd experimental week, a clearly stained lesion was observed at the gastric angle. The histological findings of the biopsy specimens from the stained lesion showed the elongation of the foveolar epithelium and goblet cell-like mucous cells. Apparently stained lesion was observed at the antral portion in the 128th week. The close-up endoscopic appearance was very similar to that of stained intestinal metaplasia seen in the human stomach. The endoscopic methylene blue staining method as performed in the experimental dogs could provide useful results in the observation of minute lesions especially intestinal metaplasia in human stomach. This experiment, and further studies, may help to elucidate the pathogenesis of the gastric carcinoma in humans.

Animals↗
PubMed1980

Clinical implications of alpha-fetoprotein in liver cirrhosis: five-year follow-up study.

The level of alpha-fetoprotein (AFP) was estimated by radioimmunoassay or passive hemagglutination method in a series of 159 patients with liver cirrhosis, and the incidence of serum hepatitis B antigen, histopathologic features of the liver, incidence of development of hepatocellular carcinoma (HCC) and mortality in AFP-positive cases were studied. Approximately 40 per cent of the patients had an AFP level higher than 20 ng/per ml, and all the elevations of AFP over 100 ng per ml were transient. In contrast, patients who developed HCC during the course of the disease always exhibited an increasing value of AFP. The seropositivity for AFP was significantly related to the presence of serum hepatitis B surface antigen and also to liver cell dysplasia as well as to thickening of the liver cell plates. As compared with a group of AFP-negative cases, the AFP-positive group showed a higher incidence of development of HCC and poorer prognosis over a five-year follow-up period. The data obtained suggested that increased AFP-production in patients with liver cirrhosis might reflect, largely an abnormal or altered liver cell regeneration, probably associated with hepatitis B virus, and that patients with transiently elevated AFP values might be at greater risk for the development of HCC.

Carcinoma, Hepatocellular↗
PubMed1980

Studies of alpha-napthylisothiocyanate-induced hepatic disturbance.

In order to clarify the mechanism of alpha-naphthylisothiocyanate (ANIT) induced cholestasis in rats, a few hepatic changes seen after administration of ANIT 80 mg/kg body weight were examined in relation to time. To clarify changes in the bile production system and bile flow, the concentrations of bile acid and bicarbonate, as well as of sodium in the bile, were measured after infusion of secretin and taurocholic acid. The canalicular bile flow was estimated by measuring the biliary clearance of erythritol-C14. To assess hepatocellular injury, the levels of cytochrome P-450 in the microsome of hepatocytes and protein synthesis in the liver were estimated. It seems that ANIT is activated in the drug metabolising system through cytochrome P-450 in the liver, and significant changes are produced in both the bile acid metabolism and its transport system. Bile acid-independent bile flow in the canaliculus was inhibited, too. Hence, both the bile ductules and the bile ducts are functionally and histologically disturbed.

1-Naphthylisothiocyanate↗
PubMed1980

Death and its effects on the family household: implications thereof within a Japanese pioneer agricultural community in the eastern lowlands of Bolivia.

Following the descriptive analysis of the deaths occurring within a Japanese pioneer agricultural community in the lowlands of eastern Bolivia, the impact of death on the permanency of the household and the family farming system was analyzed. During the 20 years since the establishment of the colony, adult male deaths were in a greater than twofold excess over those of adult females, and one-third of the number of deaths was attributable to unnatural causes. The death of adult members of the household was not directly related to remigration, but a significant association with remigration was found in the specific cases of death of the household head: the cases of sudden death from unnatural causes, or the cases in which the household contained no adult male who would take over the role of practicing pioneer farming after the demise of the head. The data also showed a retarded agricultural development where the head had died at an early stage of the establishment of the household. The results suggest that the family structure and the family life cycle of a household has an important safety-valve role in maintaining adjustment potential in the community.

Accidents, Occupational↗