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Biomedical subjects

T Takemoto

Publications and source records attributed to T Takemoto.

At least 199 records · Page 11Linked to original sources
PubMed1982

[Treatment and prevention of infections with cefoxitin sodium in patients with biliary tract infections and obstructive jaundice].

UNLABELLED: A total of 24 patients who was hospitalized in the Internal Medicine Wards of Yamaguchi University attached Hospital and the university's 3 related hospitals were administered with cefoxitin. The breakdown of the patients treated with cefoxitin was 7 with cholecystitis, 7 with choledochitis and the remaining 10 for the prevention of infections with obstructive jaundice. Daily doses of 2-6 g of cefoxitin were administered for 6-40 days by intermittent intravenous drip infusion in divided doses. RESULTS: 1. Of 14 patients with biliary tract infections, 10 (71.4%) responded favorably with cefoxitin. 2. Of 10 patients with obstructive jaundice used for the prevention of infections, 8 (80%) responded favorably with cefoxitin. 3. No untoward side effects were observed. 4. Cefoxitin proved to be a safe and effective antibiotic in the treatment of biliary tract infections and for the prevention of infections in patients with obstructive jaundice.

Adult↗
PubMed1982

Immunosuppressive effect of a trichothecene mycotoxin, Fusarenon-X in mice.

The in vitro treatment with Fusarenon-X, a mycotoxin produced by Fusarium nivale Fn 2B, depressed the mitogenic responses of mouse lymphocytes to the T-cell mitogens, phytohaemagglutinin (PHA) and concanavalin A (Con A), but to a lesser extent to B-cell mitogen, a bacterial lypopolysaccharide (LPS). The in vitro treatment of mice with Fusarenon-X also decreased the responsiveness of splenic lymphocytes to the T-cell mitogen, Con A. Administration of Fusarenon-X to BALB/c mice before immunization significantly reduced anti-DNP IgE and IgG1 responses, while the treatment of mice after immunization was less effective. The number of spleen cells of the treated mice was increased with a reduction of T lymphocytes and an increase of granulocytic elements. In vitro antibody responses of spleen cells from Fusarenon-X treated mice by pokeweed mitogen (PWM) or LPS were also suppressed. Reconstruction experiments using sIg positive and negative spleen cells from normal and Fusarenon-X treated mice showed that this inhibitory effect resided in the sIg negative cell population.

Animals↗
PubMed1981

Terpenoids biotransformation in mammals III: Biotransformation of alpha-pinene, beta-pinene, pinane, 3-carene, carane, myrcene, and p-cymene in rabbits.

The biotransformation of (+)-, (-)-, and (+-)-alpha-pinenes, (-)-beta-pinene (nopinene), (-)-cis-pinane, (+)-3-carene, (-)-cis-carane, myrcene, and p-cymene in rabbits was investigated. The major metabolites were as follows: (-)-trans-verbenol from (+)-, (-)-, and (+/-)-alpha-pinenes; (-)-10-pinanol and (-)-1-p-menthene-7,8-diol from (-)-beta-pinene; (-)-alpha-terpineol and (-)-trans-sobrerol from (-)-cis-pinane; (-)-m-mentha-4,6-dien-8-ol, 3-caren-9-ol, (-)-3-carene-9-carboxylic acid, and 3-carene-9,10-dicarboxylic acid from (+)-3-carene; carane-9,10-dicarboxylic acid from (-)-cis-carane; and myrcene-3(10)-glycol, myrcene-1,2-glycol, uroterpenol, and p-cymene-9-carboxylic acid from p-cymene. These metabolisms include allylic oxidation, epoxidation, stereoselective gem-dimethyl hydroxylation and its oxidation, cleavage of a conjugated double bond by epoxidation, and regioselective oxidation, some of which are not found usually in chemical reactions, and due to which various new compounds were determined. This biotransformation of the monoterpene hydrocarbons gave some insect pheromones in high yield.U

Acyclic Monoterpenes↗
PubMed1981

Killer cell (K-cell) population in chronic liver disease.

Peripheral blood killer cell (K-cell) population of patients with chronic hepatitis was investigated by means of a plaque-assay method using sheep red blood cells. The mean K-cell population of 14 control subjects was 5.1 +/- 2.0% (mean +/- SD), and that of 28 patients with chronic hepatitis was 4.4 +/- 3.1%. These 28 patients were divided into three groups: CPH, CAH 2A and CAH 2B. The mean K-cell population of each group was decreased in order of the severity of the disease. Especially, that of patients with CAH 2B was a statistically significant decrease (p less than 0.01) from control subjects. In the course most patients with CAH, K-cell population did not change for three months after admission. K-cell population was observed to decrease in the patients with active stage of liver cirrhosis, but not in patients with the terminal stage of liver cirrhosis, even in hepatoma patients. It is suggested that the K-cell population may play an important role of pathogenesis of chronic hepatitis.

Antibody-Dependent Cell Cytotoxicity↗
PubMed1981

Representation of T cell functions in liver bearing hepatocellular carcinoma.

Thymus-derived cells (T cells) were stained by the immunofluorescent technique, and found to be predominate around the cancer cell nests, in the interstitium, and in the lumen of the sinusoid of the liver bearing hepatocellular carcinoma (hepatoma). The marked T cell predominance in the liver obtained at autopsy in 19 of 13 patients with hepatoma indicates that specific T cell-mediated immunity may be maintained even in the terminal stage of cancer in these patients.

Carcinoma, Hepatocellular↗
PubMed1981

Ranitidine: a pilot study in Japan.

Twenty-four patients with gastric ulcer and 18 with duodenal ulcer diagnosed by endoscopy were treated with ranitidine, 300 mg day-1, for 8 consecutive weeks, or until the ulcer was found endoscopically healed. Of the 24 with gastric ulcer, 50% were healed within 4 weeks, and 83% within 8 weeks. Of 18 cases with duodenal ulcer, 50% were healed within 2 weeks and 94% within 4 weeks. Therapeutic effect of ranitidine was statistically significant compared with placebo. Side effects due to ranitidine administration were few and consisted of a rash in one case and slight increase of transaminase in a few patients.

Adult↗
PubMed1981

Increase of T cells in the liver during hepatocarcinogenesis with N-2-fluorenylacetamide in rats.

The localization of thymus-derived lymphocytes (T cells) was investigated in rat liver by the immunofluorescence method during hepatocarcinogenesis with N-2-fluorenylacetamide. In the early stage of carcinogenesis, the number of T cells never increased significantly in livers in which hyperplastic liver nodules (population I) were seen. On the other hand, in the late stage of carcinogenesis, T cells extensively invaded hyperplastic nodules (population II) as well as hepatomas. According to the concept of cell-mediated immunity, hyperplastic nodules in the late stage might have a neoantigen(s) which evokes the response of T cells. Therefore, it may be concluded that populations I and II are biologically distinct lesions in spite of their histological identity.

2-Acetylaminofluorene↗
PubMed1981

Prevention of gastric ulcers in swine by feeding of sodium polyacrylate.

Five experiments involving 169 swine were conducted to determine the effects of 0.1% to 0.5% sodium polyacrylate (PANa) in rations of growing swine on weight gain, feed conversion, and occurrence of esophagogastric lesions. Seemingly, PANa prevented swine from developing esophagogastric ulcers. Esophagogastric ulcers or erosions occurred in 42.9% of the swine fed a PANa-free diet, but occurred in only 9.8% of those fed a diet containing PANa. Addition of PANa (0.1% to 0.5%) to the growing ration increased weight gain and feed conversion. The anti-ulcer effect of PANa was discussed.

Acrylic Resins↗