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Biomedical subjects

T Sueda

Publications and source records attributed to T Sueda.

At least 127 records · Page 7Linked to original sources
PubMed1996

Increased expression of interleukin-1 receptors on fibroblasts derived from inflamed gingiva.

We investigated the expression of interleukin-1 receptors (IL-1R) on the surfaces of cultured gingival fibroblasts derived from healthy and inflamed gingiva and the effects of IL-1 alpha and IL-1 beta and prostaglandin E2 (PGE2) on IL-1R expression. Fibroblasts were obtained from explant culture of both healthy and inflamed gingiva. IL-1R on cell surfaces was detected immunohistochemically using an anti-human IL-1R monoclonal antibody. IL-1R expression was assessed quantitatively using an enzyme linked immunosorbent assay (ELISA). Positive staining for IL-1R was more evident on cells from inflamed gingiva compared with cells from healthy gingiva. The ELISA showed a significantly increased number of IL-1R on cells from inflamed gingiva compared with cells from healthy gingiva (P < 0.05). Treatment with IL-1 but not PGE2 increased expression of IL-1R on fibroblasts. These findings suggest that gingival fibroblast responses to IL-1 may represent a mechanism for amplification of gingival inflammation.

Adult↗
PubMed1996

Radiofrequency catheter ablation for a patient with Wolf-Parkinson-White syndrome associated with sustained atrial tachycardia.

Successful catheter ablation for a patient with both Wolff-Parkinson-White syndrome and sustained atrial tachycardia has not been reported. We describe a patient with Wolff-Parkinson-White syndrome associated with sustained atrial tachycardia, in whom an atrioventricular accessory pathway and an intra-atrial reentrant circuit were successfully ablated in a single session. Radiofrequency catheter ablation for the left-sided atrioventricular accessory pathway was performed via the trans-septal approach. Catheter ablation for the atrial tachycardia was achieved in the right atrium where the earliest and fractionated atrial activation was obtained. Catheter ablation for multiple lesions during a single session is feasible.

Catheter Ablation↗
PubMed1996

Response of conductance and resistance vessels of the coronary artery to intracoronary isosorbide dinitrate in patients with variant angina.

To elucidate the response of conductance and resistance vessels of the coronary artery after intracoronary isosorbide dinitrate (ISDN), we evaluated 11 patients with variant angina and 13 controls with a Doppler guidewire. Epicardial arterial diameter increased significantly after ISDN in patients with variant angina while it did not change significantly in the controls. Coronary diastolic flow velocity increased significantly in controls (p < 0.05), but was unchanged in patients with vasospastic angina. Coronary flow volume increased from 23.8 +/- 18.6 to 46.5 +/- 28.4 ml/min in patients with vasospastic angina as well as in the controls from 32.2 +/- 24.2 to 54.7 +/- 44.4 ml/min. Coronary resistance did not differ between the two groups before or after the injection of ISDN. Conductance vessels were dilated to a greater extent in the patients with variant angina. However, the response of resistance vessels did not differ significantly between the two groups.

Aged↗
PubMed1996

[Efficacy of left atrial only procedure for the treatment of chronic atrial fibrillation associated with mitral valve disease].

We supposed that chronic atrial fibrillation originated as a result of discontinuity of the refractory period of the dilated left atrium in the mitral valvular disease. We then performed left atrial only procedures to treat the chronic atrial fibrillation (AF) associated with mitral valve disease. These procedures were the left atrial isolation and the modified left sided maze procedure, consisting of isolation of all pulmonary veins and cryoablation to the posterior wall of the left atrium, in addition to excision of the left atrial appendage. Twenty-eight patients underwent these procedures over the past thirty months. Patient ages and the duration of AF ranged from 37 to 71 years and from 0.5 to 26 years, with an average of 8.3 years, respectively. Chronic AF disappeared in twenty-four patients (86%) at discharge. Three patients with severe tricuspid insufficiency had sustained AF and one patient had atrial flutter postoperatively. Three patients showed sick sinus syndrome postoperatively and two of these required a DDD pacemaker. Severe tricuspid regurgitation (p < 0.020) was the factor in recurrence of AF. Left atrial only procedures were effective in the treatment of chronic AF associated with mitral valvular disease.

Adult↗
PubMed1996

Numerical simulation of nonpulsatile left ventricular bypass.

A computer simulation was carried out to investigate the influence of nonpulsatile left ventricular assistance on hemodynamics. A simulation circuit was constructed to represent the circulatory system. A source of current was added to denote the nonpulsatile blood pump. The left and right ventricles were replaced by variable compliances. Left heart failure was simulated by decreasing the amount of compliance change of the left ventricle. We introduced a pulsatility indicator (PI) to clarify the pulsatility characteristics in the hemodynamics; this PI was defined as the ratio of the pulse pressure (PP) to the mean aortic pressure (AoP). When nonpulsatile bypass flow increased, the mean AoP, tension time index (TTI), and diastolic pressure time index (DPTI) increased, and cardiac output, PP, and PI decreased. When assisted flow increased with the constant total flow rate, the mean AoP and DPTI changed little; the PP, TTI, and PI decreased, and the endocardial viability rate increased. The PI would be helpful in evaluating the effect of pulsatility.

Blood Pressure↗
PubMed1996

[Role of noninvasive graphic diagnosis in acute type A aortic dissection and selection of the adjunct for cerebral protection].

We have evaluated the usefulness of graphic diagnostic modalities (transthoracic echocardiography [TTE], high speed CT, transesophageal echocardiography [TEE], surface echocardiography [SE]) in acute type A aortic dissection and selected the adjunct to protect cerebral damage during operation followed by pre and intraoperative diagnosis. 1) Angiopraphy was undergone in only 5 cases of 22 cases of acute type A dissection. Intimal flap of the ascending aorta was completely diagnosed by TTE and CT. It was sometimes difficult to show the location of the intimal tear by TTE and CT (diagnostic sensitivity 64%, specificity 88%). However, TEE and SE showed the location of intimal tear in all cases (sensitivity 100%, specificity 100%) and also clarified the dissection of the coronary arterial orifice. CT and SE were useful to detect dissection of the cervical branches. 2) The adjunct for cerebral protection was selected by the diagnosis of the distension of the dissection. Retrograde cerebral perfusion was used in the cases with intimal tear in the ascending aorta (10 cases) and selective cerebral perfusion was selected in cases of the distended dissection, in which dissection involved the arch aorta and replacement of aortic arch was required (12 cases). Cerebral perfusion time and operative mortality was 48 min and 10% in the former and 72 min and 17% in the latter, respectively. Operative mortality was not different in both groups.

Adult↗
PubMed1996

[A case report of bypass grafting for coronary atherosclerosis with anomalous origin of the left coronary artery from the right coronary artery ostium-anterior subtype].

A 73-year-old female began to suffer from effort-induced chest pain and later disabling angina pectoris. Coronary angiographic evaluation disclosed that both the right and left coronary arteries originated from the right sinus of Valsalva. The dominant right coronary artery had a normal course with a 90% narrowing in the first segment. The left main trunk crossed anteriorly the pulmonary artery conus, thereafter dividing into the left anterior descending and circumflex coronary arteries with two 99% narrowings in the seventh and eleventh segment. She underwent bypass of the left anterior descending and right posterior descending coronary arteries with the left interthoracic artery, the right gastroepiploic artery, and saphenous vein graft on cardiopulmonary bypass support. The postoperative course was uncomplicated.

Aged↗
PubMed1996

The protective effect of low power He-Ne laser against erythrocytic damage caused by artificial heart-lung machines.

We studied the protective effects of low power He-Ne laser irradiation on erythrocytes against the damage caused by experimental artificial heart-lung machines. The erythrocyte suspension in a closed circuit was perfused with a roller pump. One of two circuits was used for laser treatment and the other for control. The laser group demonstrated significantly higher erythrocyte deformability and erythrocyte ATP levels, and lower free hemoglobin and lipid peroxide levels. A laser output power of 8.5 mW was most effective in protecting the erythrocytes. A further morphological finding using a scanning electron microscope showed fewer echinocytes and more discocytes in the laser group. This finding was consistent with the results of physiological and biochemical tests. Low power He-Ne laser irradiation was shown to protect human erythrocytes from the damage caused by an experimental artificial heart-lung machine, raising the possibility of the clinical application of low power He-Ne laser treatment during extracorporeal circulation in cardiovascular surgery.

Erythrocytes, Abnormal↗
PubMed1996

Difference between proximal and distal right coronary flow velocity pattern in humans.

The purpose of this study is to clarify the difference between proximal and distal right coronary artery flow velocity pattern in humans. Each portion of the coronary artery in thirteen patients with chest pain syndrome was measured by means of Doppler guide wire. The systolic/diastolic peak velocity ratio and velocity integral ratio at the proximal portion of the right coronary artery were significantly higher than those at distal portion of the right coronary artery (0.97 +/- 0.27, 0.61 +/- 0.20, 0.66 +/- 0.19, 0.44 +/- 0.13, respectively). In the right ventricular branch, coronary flow velocity pattern showed systolic dominancy. Systolic/diastolic peak velocity ratio and integral ratio showed 1.69 +/- 0.62 and 1.00 +/- 0.62 in the right ventricular branch, respectively. It is speculated that the less marked diastolic predominant pattern in the proximal right coronary artery flow velocity may be due to the fact that the proximal right coronary artery supplies both the right and left ventricle but that the distal right coronary artery supplies only the left ventricular inferior wall.

Aged↗
PubMed1995

Characterization of nodules induced by bioactive glass on cultured periodontal-ligament fibroblasts.

We previously reported that materials leached from bioactive glass (BG) and vitamin D3 induced the formation of nodules on cultured periodontal-ligament fibroblasts (PLF). In this study, we have investigated the relationship between the conditions of the materials and nodule formation, analyzed morphologically, and also studied whether the production of nodules was specific to cultured PLF. PLF and skin fibroblasts were cultured in the presence or absence of BG. The amounts of calcium, phosphate, sodium and silicon in the culture medium and the number of nodules were measured at the 55th day. The nodules were observed microscopically and analyzed using an X-ray microanalyzer. In PLF, nodules were formed regardless of the presence or absence of BG; however, they were more numerous in the presence of BG. In skin fibroblasts, nodules were not observed. The amounts of calcium and silicon were higher in the presence of BG, while the amount of phosphate was lower. The nodules appeared crystalline with a spongy structure and contained calcium and phosphorus. Our results show that the nodules were associated with PLF and precipitated by the materials (higher concentrations of calcium and silicon), and they were spongy crystal composed of calcium and phosphorus.

Biocompatible Materials↗
PubMed1995

Relation between collateral flow assessed by Doppler guide wire and angiographic collateral grades.

We investigated the relation between the angiographic collateral grade (Rentrop's classification) and the collateral flow velocity pattern in 43 patients with angina pectoris. Collateral flow velocity was measured with a Doppler guide wire during balloon occlusion in coronary angioplasty. Collateral flow was detected in 21 of the 43 patients. In 6 of the 21 patients, collateral vessels were not seen angiographically before angioplasty. The direction of collateral flow was classified as forward, backward, or bidirectional. Forward and backward collateral flows were seen in all angiographic grades. Bidirectional collateral flows were observed only in grades 0 to 2. The peak collateral flow velocity was not correlated with the angiographic grades, but the ratio of the collateral flow duration to a cardiac cycle length was correlated with them (grade 0, 44% +/- 15%; grade 1, 70% +/- 16%; grade 2, 84% +/- 11%; and grade 3, 93% +/- 3%; p < 0.0005, analysis of variance). The peak velocity integral was also correlated with the angiographic collateral grades (p < 0.05; analysis of variance). The peak velocity integral was also correlated with the angiographic collateral grades (p < 0.05; analysis of variance). Electrocardiographic signs of ischemia were less observed in patients with unidirection and longer duration of collateral flow pattern (p < 0.05, respectively). A Doppler guide wire may be useful in assessing collateral flow grade.

Aged↗
PubMed1995

Pulsatile total artificial heart using a reversible rotary pump.

A pump circuit was assembled and examined for use as an implantable artificial heart. The circuit consisted of a gear pump and 4 artificial heart valves. Mitral and pulmonary arterial valves were placed at the inflow port of the pump, and aortic and tricuspid valves were placed at the outflow port. The mitral and the tricuspid valves were connected to each reservoir at 10 mm Hg, and the aortic and the pulmonary arterial valves were connected to the head tanks at 80 and 20 mm Hg, respectively. The pump discharged pulsatile flows into both systemic and pulmonary arteries alternately by switching the direction of rotation periodically. Because the rated discharge was 1.7 L/min for the gear pump used, the measured flow rate was 0.8-0.75 L/min at a heart rate of 60-110 bpm.

Aortic Valve↗
PubMed1995

[Evaluation of serum granulocyte colony stimulating factor and granulocyte counts in patients with extracorporeal circulation].

To clarify the physiologic roles of granulocyte colony stimulating factor (G-CSF) in increasing granulocyte after extracorporeal circulation (ECC). The serum levels of G-CSF, C3a, granulocyte elastase and granulocyte count were examined in 26 patients undergone open heart surgery. These patients were divided into two groups, the long perfusion group (11 patients) and the short perfusion group (15 patients). Granulocyte increased immediately after ECC and reached maximum 48 hours after ECC in both groups. C3a showed significant increase at the end of ECC and decreased rapidly after ECC in both group. G-CSF showed high levels 3 and 6 hours after ECC in the short perfusion group and moderate increase prolonged until 48 hours after ECC in the long perfusion group. Granulocyte elastase showed high levels 6 hours after ECC and decreased to the normal value 48 hours after ECC in the short perfusion group, and high levels prolonging until 48 hours after ECC in the long perfusion group. Increase of granulocyte count might be affected with increase of compliment (C3a) and G-CSF at the early and late phase after ECC, respectively. Granulocyte elastase increased differently by the duration of perfusion time.

Adult↗
PubMed1995

[Complications of endocardial biopsy in heart transplant patients].

Despite the increasing use of alternative techniques, endomyocardial biopsy remains the primary method for diagnosing cardiac allograft rejection. Between March 1986 and May 1994, 2,894 endomyocardial biopsies performed on 183 heart transplant patients were reviewed. A total of 53 (1.8%) complications occurred. 33 (1.1%) complications were associated with the introduction, including carotid puncture (0.9%), neurological reaction (0.1%), and pneumothorax (0.1%). Complications during biopsy included arrhythmias (0.4%) and ventricular perforation (0.2%). In addition, we observed three episodes of allergic reaction to a reusable biotome, three episodes of liver biopsy, and one case of pacemaker dislodgement. All complications were without significant long-term sequelae. In contrast to the cardiomyopathy population, no severe ventricular perforations or deaths occurred. Thus although endomyocardial biopsy has some risk, it continues to be a safe and effective way of monitoring rejection.

Adolescent↗
PubMed1995

[A case report of closing aortic dissection with cardiac tamponade which developed re-dissection three weeks later].

A 57-year-old female with hypotension and consciousness disturbance was referred to our institute. Echocardiography and plain CT revealed cardiac tamponade, but no apparent evidence of aortic dissection was obtained. With sudden onset of hypotension, she was immediately operated without information of aortography, enhanced CT, and MRI. Approximately 200 g of pericardial hemorrhage and slight subadventitial hematoma was grossly found and surface ultrasonography revealed the mild localized intramural hematoma (crescent-shaped translucent layer of at most 5 mm in width) at the proximal ascending aorta. Because neither false lumen with blood flow nor intimal flap was found, pericardial drainage without aortic replacement was performed. However, DeBakey type II of aortic dissection with wide false lumen was found with CT and MRI within three weeks, and re-operation was carried out. The dissection ranged from the ostium of right coronary artery to the beginning of innominate artery, but did not involve the coronary arteries and major branches of aortic arch. The surface ultrasonography and transesophageal echocardiography, as well as preoperative CT and MRI, demonstrated that false lumen was thrombosed except at the anterior aspect of mid-portion of ascending aorta. The ascending aorta was replaced. A careful follow-up is mandatory for even a localized intramural hematoma, which can progress into aortic dissection in a short period.

Aortic Dissection↗
PubMed1995

[Thromboembolectomy using cardiopulmonary bypass for acute pulmonary embolism with nephrotic syndrome--report of a case].

We report a case treated with thromboembolectomy using cardiopulmonary bypass for acute pulmonary embolism caused by nephrotic syndrome. A 19-year-old male with poorly controlled nephrotic syndrome was admitted associating with severe shock. An acute pulmonary embolism was diagnosed by ECG and echocardiography. Despite the intensive thrombolytic therapy, hemodynamics was deteriorated. Pulmonary arteriography demonstrated obstruction of left main pulmonary artery and partial defects of right pulmonary artery bifurcation and right middle-lower pulmonary arteries. An emergent thromboembolectomy using cardiopulmonary bypass was performed successfully. In conclusion, an emergent surgical treatment is required in the case of acute massive pulmonary thromboembolism which shows hemodynamic deterioration in spite of recent intensive medical treatment.

Acute Disease↗
PubMed1995

[The effectiveness of perfluorotributylamine/pluronic F-68 stem-emulsion (FC43se) against xenograft rejection in the guinea pig-to-rat model].

The administration of perfluorotributylamine/pluronic F-68 stem-emulsion (FC43se), a fluorine compound emulsion, to a rodent discordant xeno-transplantation (dXT) model led to the discovery of the inhibitory effect of this compound against hyperacute rejection (HAR). When a guinea pig heart was transplanted to a rat administered with FC43se (10 microliters/g body weight), rhythmic beating was maintained for 1110 +/- 111.1 min (mean +/- SD; n = 8) whereas the untreated heart continued to beat for 15.5 +/- 6.6 min (mean +/- SD; n = 8). After 720 min of re-beating; pathologic changes observed in the untreated group, such as multiple thrombosis in the coronary vessels, were not observed in the FC43se-administered group by light and electron microscopic examination, and endothelial cells were well preserved. On the other hand, scattered necroses of the myocardium were observed and lymphocytic infiltration was demonstrated in the interstitium. We concluded that FC43se possessed a HAR inhibitory effect by inhibiting thrombus formation in the xeno-graft heart. Using this model, we speculated that action in the vessels of the graft heart (intravascular HAR) caused thrombus formation in the vessels. On the other hand, extravascular HAR causes myocardial necrosis more slowly, not resulting in cardiac arrest in the short term.

Acute Disease↗