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Biomedical subjects

T Suchi

Publications and source records attributed to T Suchi.

At least 109 records · Page 6Linked to original sources
PubMed1985

Three cases of primary splenic lymphoma. Case report and review of the Japanese literature.

Three cases of primary splenic lymphoma (two diffuse large cell (DL) lymphomas; and one follicular mixed small cleaved and large cell (FM) lymphoma according to the Working Formulation) are presented. Histologically as well as immuno-histochemically, all were considered to be of follicular center cell origin. Reticulin stains clearly demonstrated that the white pulp was primarily involved both in FM and DLs. Remnants of clusters of dendritic reticular cells were demonstrated immuno-histochemically in one case of DL. Primary splenic lymphomas in the Japanese literatures were reviewed and compared with those in the American literatures. It was found that "solitary mass" was the predominant gross feature (81%) and "reticulum cell sarcoma" was the predominant histologic type (66%) in Japan. In the United States, lymphosarcoma was the predominant histologic type (39%), reflecting the histologic distribution of nodal lymphomas, and "homogeneous" or "miliary" was the predominant gross feature (71%).

Adult↗
PubMed1985

Chronic thyroiditis as a risk factor of B-cell lymphoma in the thyroid gland.

In order to contribute to the etiological study of thyroid lymphomas, the development of lymphomas in pre-existing chronic thyroiditis was statistically investigated. A total of 5592 female patients (older than 25 years) with chronic thyroiditis diagnosed between 1965 and 1982 at Kuma Hospital in Hyogo Prefecture were followed up until December 31, 1984. From a total of 45623 person-years, 8 new cases of primary thyroid lymphoma were observed (O), all of which were judged to be B-cell type from their immunological or histopathological characteristics. Since the expected number of cases with malignant lymphomas (E1) and the expected number of cases with thyroid lymphomas (E2) were 2.45 and 0.10, respectively, the O/E1 and O/E2 ratios were 3.3 (P less than 0.01) and 80.0 (P less than 0.001), respectively. The average follow-up interval for the patients with thyroid lymphoma was 9.2 years. In the reference group, consisting of cases with Basedow's disease, an increased risk of thyroid lymphoma was not observed. The present results suggest that autoimmune reactions with a notable lymphocytic infiltrate may play an important role in the etiology of lymphomas in the thyroid gland.

Adult↗
PubMed1984

Six recent liposarcomas including largest to date.

This report describes six cases of liposarcoma. The primary sites were the retroperitoneum in three cases, the lower extremity in two cases and the jejunal mesenterium in one case. One retroperitoneum case had the heaviest liposarcoma (40 kg) that has been reported in the literature. One patient with thigh liposarcoma who developed three recurrences and underwent hemipelvectomy has been free from the disease for the past 6 1/2 years. Histologically, all three retroperitoneum cases showed well-differentiated liposarcoma and two lower extremity cases had myxoid type liposarcoma.

Adult↗
PubMed1984

Immunoelectron microscopic studies on peripheral T-cell lymphomas using monoclonal antibodies.

Ultrastructural comparison between helper/inducer and suppressor/cytotoxic type cells in peripheral T-cell lymphomas was made using the immunoperoxidase technique. The nuclei of T4 positive cells were more irregular in outline than those of T8 positive cells, and nuclear irregularity was further pronounced in the cells of the adult T-cell leukemia/lymphoma which were of helper/inducer type cells. The suppressor/cytotoxic type cells possessed in their cytoplasm scattered dense bodies encircled by distinct membranes, although they also contained clustered dense bodies. On the other hand, the helper-inducer type cells had only clustered dense bodies. No other significant differences were observed regarding other cytoplasmic organelles between T4 positive cells and T8 positive cells. The existence of the peripheral T-cell lymphomas with "double-markers" which possessed surface antigens for both helper/inducer and suppressor/cytotoxic subsets was also demonstrated.

Antibodies, Monoclonal↗
PubMed1984

HLA antigens and adult T-cell leukemia virus infection: a community-based study in the Goto Islands, Japan.

In order to study the genetical susceptibility to infection by adult T-cell leukemia virus (ATLV), which is considered to be a main causative agent of adult T-cell leukemia (ATL), the HLA profile of persons with antibody against ATLV-associated antigen (anti-ATLA) was compared with that of antibody-negative persons in villages A and B of the Goto Islands, a typical ATL endemic area in Kyushu, Japan. The frequency (29%) of HLA-B7 in persons with anti-ATLA was significantly higher than that (8%) in anti-ATLA negatives (corrected X2 = 7.73, p less than 0.01) in one village while the frequency of HLA-B7 was around 10% in both positive and negative persons in the other village. These results do not support or deny the possibility of the existence of individuals who are genetically susceptible to ATLV infection in ATL endemic areas of Japan.

Adult↗
PubMed1983

Serological analysis of cell surface antigens of HL-60 cells before and after treatment with a phorbol ester tumor promoter.

The human HL-60 cell line derived from acute promyelocytic leukemia, consisting of promyelocytic type of cells, was able to differentiate into adherent cells with monocytemacrophage features by the treatment with 12-0-tetradecanoyl phorbol-13-acetate (TPA). Cell surface antigens of HL-60 cells before and after TPA treatment were studied with monoclonal antibodies and four hybridoma clones producing IgM antibodies were established. Two antibodies (HL-21 and HL-47) reacted only with the immunizing TPA-treated HL-60 cells, and HL-1 antibody produced against untreated cells was reactive with both TPA-treated and untreated cells, but HL-5 antibody reacted predominantly with the immunizing untreated cells. Serological reactivity against various types of normal hematopoietic cells and acute leukemias (diagnosed by the French-American-British classification) was studied by immune adherence assay and immuno-electron microscopy. HL-21 antibody was reactive with monocytes and most cases of M4 and M5 types of acute non-lymphocytic leukemia cells. HL-47 antibody did not react with the cells of myelocyte-monocyte lineage or mature lymphocytes, but it did react with one-third of acute lymphocytic leukemia (L1 and L2) cases. Since all HL-47+ cases were included in the group of common ALL antigen positive cases, it was estimated that HL-47 is a differentiation antigen present on lymphocyte precursors, from which null-cell type acute lymphocytic leukemia cells generally originate. HL-1 antibody reacted with the cells of myelocyte-monocyte lineage as well as those of most acute non-lymphocytic leukemias. HL-5 antibody reacted with granulocytes and M2 type of acute myelocytic leukemia cases, and also with M5 type of acute monocytic leukemia cases. Serological studies of these antibodies revealed that TPA can induce to differentiate HL-60 cells not only into HL-21+ macrophage-like cells, but also into HL-47+ lymphoid stem cells. In addition, these antibodies were demonstrated to be very valuable for differential diagnosis of acute leukemias.

Antibodies, Monoclonal↗
PubMed1983

Secretory component and IgA in endometrial adenocarcinomas. An immunohistochemical study.

The localization of secretory component (SC) and IgA was immunohistochemically studied in 6 normal endometrium and 55 endometrial adenocarcinomas including 34 well, 11 moderately and 10 poorly differentiated ones. In normal endometrium, SC localization was found in the cytoplasm of epithelial cells and luminal contents of the gland. IgA showed similar localization of SC. Secretory phase endometrium contained proportionally larger numbers of positive cells for SC and IgA than proliferative phase endometrium. SC localization was found in all cases of well and moderately differentiated carcinomas, while it was found only in 4 cases out of 10 poorly differentiated carcinomas. IgA localization was similar to that of SC and this condition was thought to reveal the binding of IgA to SC existing in the tumor cells. The present immunohistochemical study revealed that the staining intensity of SC well correlated with the histological grade of differentiation of the tumors.

Adenocarcinoma↗
PubMed1983

Evaluation of serum neuron-specific enolase as a tumor marker for carcinoma of the lung.

Serum neuron-specific enolase (NSE) was measured in 80 normal subjects, 20 patients with small cell carcinoma of the lung (SCCL) and 54 patients with non-small cell carcinoma (non-SCCL). The mean value in the control group was 2.1 +/- 0.4 ng/ml (range, from 1.3 to 3.0 ng/ml). Serum levels exceeding 7.5 ng/ml were tentatively defined as positive. Thirteen of 20 patients (65%) with SCCL had positive serum NSE levels, whereas 6 of 54 patients (11%) with non-SCCL had positive levels. Positive NSE in sera of patients was observed only in patients with advanced clinical stage of SCCL or non-SCCL. No correlation between serum NSE levels and metastatic sites could be found. The serum NSE levels in subtypes of SCCL were positive in 9 of 10 patients with oat cell carcinoma and 4 of 10 patients with intermediate cell carcinoma. Histological types of all positive cases with non-SCCL included large cell carcinoma. Serum NSE levels changed in parallel with the clinical course during the treatments. The data suggested that serum NSE may be a useful marker for monitoring the clinical course of lung carcinoma, especially of SCCL. Furthermore, the detection of NSE in non-SCCL is of interest in relation to the histogenesis of lung carcinomas which exhibit the properties of neuroendocrine tumors.

Adenocarcinoma↗
PubMed1983

[Neuron-specific enolase as a new tumor marker].

Enolase is a glycolytic enzyme widely distributed in each mammalian tissue and consists of three distinct subunits alpha, beta, and gamma. In the brain enolase exhibits three dimetric isozymic forms: alpha alpha, alpha gamma and gamma gamma. The gamma protein subunit has recently been found to be identical with the nervous system-specific and species-nonspecific protein, 14-3-2; therefore, alpha gamma and gamma gamma types of enolase were characterized as neuron-specific enolase (NSE). NSE has been also detected in the pituitary gland, thyroid gland, adrenal medulla and pancreas, all of which contain neuroendocrine cells. Recently NSE was observed by immunostaining or radioimmunoassay in neuroendocrine tumor such as glucagonomas, insulinomas, gut carcinoids, medullary thyroid carcinomas or neuroblastomas. Furthermore, small cell carcinoma of the lung which has been known to frequently exhibit neuroendocrine properties was found to produce NSE. In this paper NSE as a tumor marker in various cancers was evaluated by immunostaining or enzyme immunoassay which was developed by a co-worker Kato. The data revealed that serum NSE was clinically useful as a tumor marker, especially a monitoring marker of disease extent. NSE productions were also observed in adenocarcinoma of the colon or the lung and large cell carcinoma of the lung as well as small cell carcinoma of the lung and the esophagus, all of which were considered to share the biochemical features of neuroendocrine tumor. The evidence challenges a speculation that small cell carcinoma of the lung has an origin separated from the other histological types of lung carcinoma. In this meaning NSE is an important tumor marker for both clinical medicine and basic research.

Animals↗
PubMed1983

Seroepidemiological studies on the effects of filarial parasites on infestation of adult T-cell leukemia virus in the Goto Islands, Japan.

Patients with filariasis were commonly observed until 1961-1970 in the Goto Islands, an area where adult T-cell leukemia (ATL) is endemic. The positive rate of antibodies to ATL virus-associated antigen among persons with a high antibody titer to filarial antigen was higher than that among persons with a low antibody titer in both sexes. Thus, filarial parasites might have some promoting effects on ATL virus infection and/or ATL virus proliferation among inhabitants in the endemic areas of filariasis and ATL.

Adolescent↗
PubMed1983

Epidemiological features of B-cell lymphoma in japan.

Age-adjusted incidence rates for malignant lymphomas in eastern Asian countries except for the Kyushu district of Japan are lower than those in northern European, North and South American and Oceanian countries. Particularly, the incidence rates for Hodgkin's disease and follicular lymphoma are remarkably low in eastern Asian countries. Immunological and clinico-pathological analyses suggested that the estimated rate of incidence of extra-nodal B-cell lymphoma in Japan is not very different from that in the U.S.A. However, their primary sites differ as seen in gastrointestinal lymphomas, most of which are included in extranodal B-cell lymphoma. It is interesting epidemiologically that patients with colorectal lymphoma, whose distribution is closely correlated with that of colorectal cancer in both countries, is much rarer in Japan than in the U.S.A. From the epidemiological viewpoint, extranodal B-cell lymphoma in Japan could be classified by the difference in possible risk factors as follows; lymphoma of the alimentary tract, lymphoma of solid organs, lymphoma of the liver and spleen, medullary or extramedullary plasmacytoma, and Burkitt's lymphoma. In order to clarify the possible risk factors for each type of extranodal B-cell lymphoma including chronic lymphocytic leukemia of B-cell type, it seems necessary to conduct collaborative nationwide epidemiological studies in Japan.

Adult↗
PubMed1983

[Malignant intracranial lymphoma--clinical and patho-immunological study].

Clinical and patho-immunological study was made on 15 cases of primary intracranial malignant lymphoma. The average age of the patients was 45.2, however older man suffered more than younger one. Male to female ratio was 3:2. The duration between onset to diagnosis was less than 6 months in 13 cases. The common signs and symptoms were hemiparesis (60%) and signs of intracranial hypertension (45%), followed by disturbance of consciousness, visual disturbances, convulsion and signs of inflammation. The location of the lesions was in parietal lobe (44%), temporal lobe (27.8%), cerebellum (22.2%), brain stem and basal ganglia (18%). Multiple lesions were found in 4 cases. CT scan was the most diagnostic method not only to delineate the location of lesions but also to recognize the biological natures of this condition. The radiosensitivity of this tumor was also confirmed by follow-up CT scans during radiotherapy. Most of the lesions were avascular by carotid angiography, but capillary blush at the tumor site was shown in some cases. Laboratory findings revealed that derangement of gamma globulin in the serum and decline of cellular immunity were demonstrated in many cases. Surgical removal followed by whole skull irradiation was made in all cases except one. Remission of neurological signs and symptoms with disappearance of lesions on CT scan was obtained in 7 cases for one to 9 months. All cases except two survival, died during 3 to 28 months (average: 10.1). Survival rate at one year and 2 years was 35.7% and 14.3% respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1983

[Case of early malignant lymphoma scattered over the whole stomach].

Early malignant lymphoma is rare and cases with scattering over the whole stomach are extremely rare. Malignant lymphoma is frequently accompanied by R.L.H. or multiple malignant lymphoma. In our case, some lesions were difficult to distinguish from reactive lesions because cellular atypia was of a low grade. As preoperative radiograpic and endoscopic examination had suggested the lesions to be widespread, the surgical stump was carefully inspected to avoid leaving malignant cells. We discuss the surgical treatment of malignant lymphoma of the stomach.

Gastrectomy↗