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Biomedical subjects

T Singh

Publications and source records attributed to T Singh.

At least 145 records · Page 8Linked to original sources
PubMed1989

Bone marrow biopsy in staging of malignant lymphomas.

Seventy cases of malignant lymphoma studied for bone marrow involvement by Jamshidi needle trephine biopsy are reported. Bone marrow involvement was detected in 27 cases. Bone marrow biopsy helped the advancement of disease to stage IV in 22 cases though they were in stage I-III initially. Jamshidi needle biopsy was found to be a very useful diagnostic tool for detection of lymphoma deposit in the marrow.

Adolescent↗
PubMed1989

Clinical study of tetanus neonatorum.

Seventy six cases of neonatal tetanus were studied. There was preponderance of males. Short incubation period, short period of onset, low birth weight, presence of fever and tachycardia were associated with a poor prognosis. The cases were divided into 2 groups of 46 and 30. First group was given TIG while second group was given ATS. All other therapies were kept identical. Mortality rate in two groups was 97.5% and 96.5%. Corrected mortality due to tetanus per se was 22.5% and 28.5% (p-0.5). Fifteen cases (32.7%) and 12 cases (40%) in group A & B respectively were born to mothers who had already received one to three doses of tetanus toxoid. The potency of the vaccine should be ensured before it is administered to mothers, through proper maintenance of cold chain. It is concluded that TIG is not superior to ATS in managing moderate and severe grade cases.

Female↗
PubMed1989

Status asthmaticus.

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Airway Obstruction↗
PubMed1988

Estrogen receptor binding affinity and uterotrophic activity of triphenylhaloethylenes.

Radiohalogenated estrogens have considerable potential for estrogen receptor-directed imaging and therapy for cancers which contain such receptors. In an effort to evaluate the potential of the triphenyl ethylene structure for such purposes we have synthesized 3 series of 2-halosubstituted triphenylethylenes containing oxygen functions in the 4 position of both aromatic rings attached to carbon 1 of the ethylene and tested their uterotrophic activity and competition for rat uterine low salt extractable, "cytosol" estrogen receptor. Most active, both as competitors for estradiol binding to estrogen receptors and by their ability to stimulate uterine growth are the 1,1-bis-4-hydroxyphenyl derivatives although the 1,1-bis-4-acetoxyphenyl derivatives also show good receptor affinity and demonstrate uterotrophic activities. However, since uterine cytosol contains enzymes which hydrolyze the acetates to the free phenols even during the incubation in the cold used for the competitive binding studies, a significant portion of the competition shown by the diacetates is probably due to their hydrolysis products, the free phenols. The 1,1-bis-4-methoxyphenyl derivatives are weak competitive binders and demonstrate uterotrophic activity only when administered at the higher, 20 micrograms, doses. Comparing the relative activities of various halogens at the 2 position, in each series the bromo and chloro derivatives generally were of similar activity and significantly more active than the corresponding iodo derivative. The non-halogen substituted derivatives were very good competitors for estrogen receptor binding but less active with regard to uterine growth stimulation, providing evidence that in vivo the vinyl halides would appear to be relatively stable to simple dehalogenation. Since they show reasonably good apparent affinities for the estrogen receptor and apparent in vivo stability, reflected by estrogenic activity, these halogen substituted triphenylethylene derivatives appear to be promising substrates for investigations of estrogen receptor directed imaging and therapy.

Animals↗
PubMed1987

Oral habits.

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Child↗
PubMed1986

A permeability test for acute corneal toxicity.

The penetration of sulforhodamine B (SRB) into the two corneas of a freshly killed mouse was measured after one eye was briefly exposed to a solution of a possibly toxic substance. The ratio of the penetrations provides a numerical index of acute toxicity to the corneal epithelium. With a group of 6 animals, a 50% rise in the index can be distinguished at the 95% confidence level; the maximum rise achievable in practice seems to be about 30. NaOH and benzalkonium chloride (BAK) gave graded increases in the value as their concentrations rose; the rise in index corresponded roughly to the injury caused to the living eye.

Animals↗
PubMed1986

HLA antigens in schizophrenia: a family study.

HLA haplotypes A and B were studied in eight families with two or more schizophrenic members. All index cases and all but two sick relatives satisfied Research Diagnostic Criteria for the diagnosis of schizophrenia; 45 subjects were studied. Data were analysed by sequential tests for the detection of linkage and by the affected sib-pair method. The results do not support a linkage between HLA and schizophrenia.

Female↗