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Biomedical subjects

T Singh

Publications and source records attributed to T Singh.

At least 181 records · Page 10Linked to original sources
PubMed1982

Rous sarcoma virus transformed cells are resistant to cyclic AMP.

A nontransformed line of Chinese hamster ovary (CHO) cells (Pollard and Stanners, 1979) has been transformed by the Schmidt-Ruppin subgroup D strain of Rous sarcoma virus (SR-RSV). SR-RSV transformed CHO cells are shown to differ from spontaneously transformed cells in that the virally transformed cells are more resistant to growth inhibition or changes in cell shape by 8-Br-cyclic AMP or cholera toxin. SR-RSV transformed rat (NRK) cells also have a reduced sensitivity to growth inhibition by 8-Br-cyclic AMP. Cyclic AMP-dependent protein kinase was examined in SR-RSV transformed CHO cells, but no differences in enzyme level, activation by cyclic AMP, chromatographic behavior, or its ability to phosphorylate endogenous proteins in whole cells could be detected. It is concluded that transformation of CHO and NRK cells by SR-RSV alters the cells in a manner different from spontaneous transformation, and that this alteration does not affect cAMP-dependent protein kinase activity.

Animals↗
PubMed1978

Bilateral renal dysplasia (case report).

Bilateral renal dysplasia is a very rare condition, unlike unilateral renal dysplasia. We came across three cases. In one of them there were other multiple congenital anomalies. In all the cases the ureters and renal blood vessels were rudimentary. The condition is incompatible with life. The different theories explaining this congenital anomaly and the incidence of the disease are being discussed.

Female↗