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Biomedical subjects

T Silverstone

Publications and source records attributed to T Silverstone.

At least 109 records · Page 6Linked to original sources
PubMed1980

A new technique for the continuous measurement of food intake in man.

A new method for the direct measurement of solid food intake in man is described. The apparatus consists of a refrigerated food dispenser connected to an electronic recording system whereby a continuous record of food intake can be obtained over an extended period. In standardization procedures the method was found to be reliable; subsequent studies have shown it to be sensitive to the effects of anorectic drugs, and applicable to the long-term study of patients with eating disorders.

Eating↗
PubMed1980

Behavioural and subjective effects of beta-adrenergic blockade in phobic subjects.

It has been suggested that reversal of stress-induced tachycardia by beta-adrenergic blockade might be of benefit in the treatment of phobias. This was tested in a double-blind cross-over trial by exposing 22 female volunteers with spider or snake phobias to their phobic object 1 1/2 hours after administration of either tolamolol 200 mg, diazepam 10 mg or placebo. Although tolamolol abolished the stress-induced tachycardia, it had no beneficial behavioural or subjective effects. In contrast, diazepam, which had no significant effect on heart rate, improved behavioural performance. Subjective measures were more influenced by order effect than by medication.

Adult↗
PubMed1980

Is anorexia nervosa a phobic disorder? A psychophysiological enquiry.

Skin conductance changes were measured in nine patients suffering from either frank anorexia nervosa or closely related feeding disorders after presentation of a series of food- and weight-related stimuli in imagination. The conductance changes observed were either absent or small. By contrast, in two of the patients who also had specific phobias, presentation in imagination of the specific feared object led to greater skin conductance changes.

Adolescent↗
PubMed1979

Pimozide in acute schizophrenia: a pilot study.

Pimozide was used in a pilot study to treat 10 patients with frank symptoms of acute schizophrenia. Eight patients appeared to respond favourably to doses ranging from 12 to 40 mg daily. Two of the patients responded within 1 week and all 8 within 5 weeks. It was possible to discharge all 8 patients from hospital within this time period. It is concluded that oral pimozide is an effective treatment for the whole range of symptoms accompanying acute schizophrenia. Brief representative case histories are presented, and dosage recommendations for the effective treatment of acute schizophrenia with pimozide are discussed.

Acute Disease↗
PubMed1975

The effect of cyproheptadine on hunger, calorie intake and body weight in man.

The appetite stimulating action and the weight gaining potential of one month's treatment with the antihistamine and antiserotonergic compound cyproheptadine (Periactin) 4 mg three times daily was compared to placebo in a double-blind crossover trial in sixteen thin but otherwise normal volunteers who wanted to gain weight. Subjects gained significantly more weight on cyproheptadine than on placebo. There was also a corresponding relative increase in subjective hunger ratings and food intake during the period on active drug. Drowsiness was the most frequent side effect observed. These findings are discussed in relation to a possible serotonergic feeding mechanism.

Adult↗
PubMed1975

A clinical and psychometric evaluation of flurazepam.

1 The efficacy of flurazepam (15 mg or 30 mg) as a hypnotic, and the residual effects of each dose were compared with placebo in a double-blind cross-over trial involving thirty patients in a general practice setting. Patients received each medication for one week. Daily self-ratings of onset, duration and quality of sleep, together with reports of any untoward effects were made. At the end of each period of medication psychomotor tests (reaction time, pursuit rotor, tapping speed) were administered at 09.00 hours. 2 Both doses of flurazepam were significantly more effective than placebo in inducing sleep, improving the quality of sleep and extending its duration. 3 'Hangover' effects were marked following 30 mg, but not after flurazepam (15 mg). Flurazepam (30 mg, but not 15 mg) significantly impaired performance on the pursuit rotor test and tapping speed. Flurazepam thus appears to be an effective hypnotic drug with the optimum dose for use in general practice being 15 mg at night.

Anti-Anxiety Agents↗
PubMed1975

Science is measurement.

In the assessment of phobic and obsessional states three approaches have been adopted--self rating scales, observer rating scales and physiological measurements. A comprehensive approach utilising all methods is suggested in the evaluation of new treatment techniques.

Humans↗