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Biomedical subjects

T Shin

Publications and source records attributed to T Shin.

At least 199 records · Page 11Linked to original sources
PubMed1984

Drug-induced tolerance to allografts in mice. I. Difference between tumor and skin grafts.

When AKR mice were primed with viable C57BL/6(B6) spleen cells and treated with cyclophosphamide 1-3 days later, a profound tolerance to B6 tumor allografts was induced. The tolerant state was maintained completely for as long as 8 weeks. Although tumor allografts grew progressively even when inoculated after complete rejection of skin grafts, B6 skin grafts were rejected by tolerant mice. In mice tolerant of B6 tumors, production of cytotoxic antibody and cytotoxic activity was reduced profoundly, but the delayed-type hypersensitivity level decreased only slightly. We therefore presume that the decrease in cytotoxic activity may allow progressive growth of tumor allografts, but the maintenance of delayed-type hypersensitivity or a low level of cytotoxicity, or both, precludes acceptance of skin allografts.

Animals↗
PubMed1984

[Clinical evaluation of ceftizoxime in the treatment of complicated urinary tract infections].

Ceftizoxime (CZX) was given clinically to 80 patients with urogenital tract infections, in which 34 cases of complicated UTI satisfied the criteria of the UTI committee. CZX was administered for at least five days at a daily dose of 1 to 4 g in two divided doses by intravenous drip infusion. The overall clinical efficacy of CZX in 34 cases of complicated UTI was 59%, estimated by the criteria of the UTI committee. The overall clinical efficacy rate according to group of infection was: 64% for the 11 patients in the 1st group, 56% for the 9 patients in the 2nd group, 100% for the 5 patients in the 3rd group, 50% for the 4 patients in the 4th group and 20% for the 5 patients in the 5th group. No serious side effects were observed in the clinical or laboratory findings except for slight elevation in GOT & GPT values in two cases (2.5%), which returned to normal after CZX treatment. It is therefore suggested that CZX is a clinically useful and safe drug in the treatment of complicated UTI.

Adolescent↗
PubMed1984

[Chemotherapy after prostatectomy--effects of long term administration of Pivmecillinam (PMPC)].

The therapeutic efficacy of Pivmecillinam (PMPC) against urinary tract infections after prostatectomy was investigated. PMPC was orally administered at the dose of 300 mg/day for 2-14 weeks after initial intravenous postoperative chemotherapy with other antibiotics for 0-24 days (average 5.7 days). Thirty patients underwent retropubic prostatectomy and the other 59 patients received TUR-P. The chemotherapeutic efficacy for 19 patients who had over 10(3) CFU/ml of microorganisms was as follows: The effective rate was 48.4% after 2 weeks, 53.8% after 4 weeks, 66.7% after 5-6 weeks and 100% after 7-9 weeks. The prophylactic efficacy for 70 patients who had no or less than 10(3) CFU/ml of microorganisms was 64.3% after 2 weeks, 79.6% after 4 weeks, 86.7% after 5-6 weeks and 90.0% after 7-9 weeks. The overall clinical efficacy of PMPC for 89 patients was 60.7% after 2 weeks, 74.2% after 4 weeks, 83.3% after 5-6 weeks, 90.0% after 7-9 weeks and 100% after 10-14 weeks. No severe side effects were found in these 89 cases. In conclusion, PMPC is a useful drug for the long term treatment after prostatectomy.

Administration, Oral↗
PubMed1983

Adrenal myelolipoma: report of a case with CT and angiographic evaluation.

A case of adrenal myelolipoma which was diagnosed preoperatively based on the combined examinations of computed tomography and angiography is presented. Computed tomography revealed a large suprarenal fatty tumor with increased density areas secondary to hemorrhage. Angiography demonstrated that the tumor originated from the adrenal gland.

Adrenal Gland Neoplasms↗
PubMed1983

Epithelial hyperplasia of the larynx. A 10-year review of 88 patients.

A retrospective review of 88 patients with epithelial hyperplasia of the larynx seen at the Department of Otolaryngology Kurume University during the 10-year period from 1971 to 1980 was completed. The results are summarized as follows: 1) The incidence was much higher in males (78 patients) than in females (10 patients). 2) The average age was 56.8 years. 3) The lesion was located on the vocal fold in 84 cases, the ventricular fold in 3, and both vocal and ventricular folds in 1. 4) Fifty-three patients underwent surgical treatments in our hospital. Three of them developed recurrence and 6 developed carcinoma. 5) On histological re-examination, the lesions were classified into three types: simple hyperplasia (Type I), dysplasia (Type II) and carcinoma (Type III). No relationship was found between the macroscopic appearance and the histological type.

Adult↗
PubMed1983

[Neurofibrosarcoma of the perineum associated with von Recklinghausen's disease: a case report and review of the literature].

A case of perineal neurofibrosarcoma associated with von Recklinghausen's disease is reported. The patient was a 30-year-old man, who complained of a mass between the scrotum and anus. The mass was asymptomatic. On Jan. 13, 1981, simple excision was performed. Histological examination revealed neurofibrosarcoma. After 3 months he had recurrence of the perineal tumor. Combined chemotherapy and radiation therapy were performed. But, his condition became worse due to general metastasis and he died 12 months after operation. A total of 22 cases of perineal neoplasms are reviewed.

Adult↗
PubMed1981

Central location of the motoneurons supplying the thyrohyoid and the geniohyoid muscles as demonstrated by horseradish peroxidase method.

After HRP injection into the geniohyoid muscle labeled neurons were found in the ventral part of the hypoglossal nucleus, extending in the rostral two-thirds (about) of this nucleus. After HRP injection in to the thyrohyoid muscle, the labeled neurons were identified in the lateral part of the caudal one-third (about) of the hypoglossal nucleus and in the dorsomedial part of the ventral horn of C1.

Animals↗
PubMed1981

Localization of efferent neurons innervating the pharyngeal constrictor muscles and the cervical esophagus muscle in the cat by means of the horseradish peroxidase method.

Following horseradish peroxidase (HRP) injection into the cephalopharyngeal muscle (CeP), the hyopharyngeal muscle (HP), the thyropharyngeal muscle (TP), the cricopharyngeal muscle (CP) and the cervical esophagus muscle (CE) of the cat, labeled neurons were identified in the nucleus retrofacialis and the rostral part of the nucleus ambiguus ipsilaterally. The rostral end of the labeled cell column was located more rostrally for CeP and HP than for TP, CP and CE. No difference was noted within the former two or within the latter three. The level of the caudal end of the labeled cell column became more caudal in the order of CeP, HP, TP and CP. The caudal end was located more rostral for CE than for TP. The neurons for CE were located more ventro-laterally than those for the other muscles.

Animals↗