Biomedical subjects

T Senge

Publications and source records attributed to T Senge.

At least 91 records · Page 5Linked to original sources

PubMed1980

Effects of cyproterone acetate on experimentally induced canine prostatic hyperplasia. A morphological and histochemical study.

The effect of 3 alpha-androstanediol (3 alpha-diol), 17 beta-estradiol (E2) and cyproterone acetate (CA) on prostates in castrated beagle dogs were investigated by histological and histochemical examinations. A significant increase of prostatic weight occurred after 6 months' treatment with 3 alpha-diol alone and in combination with E2. Histologically and histochemically, two different types of prostatic enlargement were observed: first, administration of 3 alpha-diol resulted in diffuse glandular hyperplasia with replacement of functional activity monitored by strongly positive reactions for acid phosphatase, aminopeptidase and zinc. Second, 3 alpha-diol plus E2 produced stratified squamous metaplasia with cystic lumina and loss of the typical morphological structure. These glands showed negative reactions for acid phosphatase, aminopeptidase and zinc. In both types of prostatic hyperplasia CA abolished epithelial or metaplastic proliferation and induced atrophy of glandular epithelium. In estrogenized dogs activation of the fibromuscular stroma was obvious. CA prevented prostatic hyperplasia by atrophying epithelial effects.

Acid Phosphatase↗

PubMed1979

Role of the pituitary gland in experimental hormonal induction and prevention of benign prostatic hyperplasia in the dog.

The antiandrogen, cyproterone acetate (CPA), prevents development of prostatic hyperplasia, induced in castrated dogs by a 6 month-treatment with 5 alpha-androstane-3 alpha, 17 beta-diol (A)alone or in combination with 17 beta-oestradiol (E2). The immunoperoxidase technique was used to study functional cell types in the pars distalis of the pituitary gland and to detect growth hormone (GH) and prolactin (PRL) target sites in the prostate gland. Homologous radioimmunoassays for estimation of serum canine GH and PRL concentrations were also performed. Treatment with the combinations A + E2 and A + E2 + CPA resulted in morphological indications of stimulated GH and PRL cells and depressed gonadotrophs. This correlates well with an increase in PRL-dependent staining in glandular epithelium and fibromuscular tissue of the prostate gland. However, basal serum PRL and GH levels were not significantly affected. Treatment with A and A + E2 stimulated, while additional treatment with CPA clearly suppressed adrenocorticotrophin/melanotrophin (ACTH/MSH) cells. These findings indicate that an endocrine imbalance in hypothalamic-pituitary-adrenal function may be involved in induction and prevention of prostatic hyperplasia in the dog.

Androstane-3,17-diol↗

PubMed1979

Biochemical and histological studies on prostates in castrated dogs after treatment with androstanediol, oestradiol and cyproterone acetate.

The effect of cyproterone acetate (CA) on experimentally induced benign prostatic hyperplasia (BPH) in the castrated dog was investigated. BPH was induced by 6 months' treatment with 3 alpha-androstanediol (3 alpha-diol) alone and in combination with 17 beta-oestradiol (Oe2). RNA, DNA and zinc content of the glands were determined in addition to histological examination and measurement of the prostates. Two different types of prostatic enlargement were observed. First, 3 alpha-diol induced typical diffuse canine hyperplasia with replacement of functional activity. DNA, RNA and the zinc content of total glands were increased compared with intact controls. Second, 3 alpha-diol plus Oe2 produced on the one hand a more striking increase of prostatic weights, but on the other a loss of typical morphological structure and function. Histologically, transformation of simple glandular epithelium into stratified squamous metaplasia occurred in addition to stimulation of fibromuscular tissue. Biochemically, a relative decrease of DNA per mg tissue was measured with a fall in the RNA to DNA ratio and zinc to the values of castrates. Administration of CA resulted in an abolition of the 3 alpha-diol effect. Biochemical determinations and histological examinations revealed an effect similar to castration after treatment with 3 alpha-diol plus CA. After treatment with 3 alpha-diol plus Oe2 plus CA fibromuscular stimulation as an oestrogen effect predominated in addition to glandular atrophy and metaplastic changes, especially in prostatic ducts. Epithelial hyperplasia is an effect of 3 alpha-diol, whereas metaplastic proliferation only occurs in oestrogenized and androgenized dogs. In both types of prostatic enlargement CA prevents development of hyperplastic prostate.

Androstane-3,17-diol↗

PubMed1979

[Lipid A antibody titers in patients after ureterosigmoidostomy (author's transl)].

Lipid A antibody titers were determined over a period of 6 months by passive hemolysis test in 10 patiens who underwent cystectomy and ureterosigmoidostomy. Preoperative the sera of all patients had no detectable anti lipid A activity. After 4 weeks 4 patients showed significant elevation of lipid A antibody titers. Only in these 4 patients the titers remained elevated up to six months. The significant elevation of lipid A antibody titers in these patients were caused by a non-obstructive infection of the kidneys. The serological determination of lipid A antibody titers appears to be an appropriate method for detecting pyelonephritis after ureterosigmoidostomy.

Aged↗

PubMed1978

A study of the capacity for regeneration of rat and human Leydig cells.

The capacity of Leydig cells for regeneration was investigated in 12 patients with prostatic carcinoma, who underwent subcapsular orchidectomy, and in rats after testicular necrosis produced by cadmium chloride. In rats, reappearance of Leydig cells originating from the tunica albuginea could be demonstrated by histology. Testosterone concentrations increased parallel to regeneration of Leydig cells, while LH concentrations declined. In contrast to these findings, no rise of testosterone concentrations could be observed in patients up to 8 months after subcapsular orchidectomy. Human Leydig cells seem to have no capacity for regeneration, or endocrine function, despite the fact that some of these cells, which are present morphologically in the tunica albuginea or spermatic cord, remained.

Animals↗

PubMed1978

[The use of gentamicin-polymethylmethacrylate chains for the treatment of soft-tissue wounds in the region of the urinary tract (author's transl)].

Bactericidal concentrations of gentamicin can be attained by implanting at the site of the infection pellet chains of gentamicin-polymethylmethacrylate (PMMA) that permit the protracted release of the antibiotic for several weeks. Satisfactory healing of the wound was achieved in two cases of extensively infected soft-tissue wounds in the region of the urinary tract after temporary implantation of gentamicin-PMMA chains.

Adolescent↗

PubMed1978

[Testosterone serum concentrations after subcapsular orchiectomy (author's transl)].

Twelve patients with prostatic carcinoma in stage C or D underwent subcapsular orchiectomy. Testosterone serum concentrations were measured by radioimmunoassay before and up to eight months following orchiectomy. After an initial decrease, testosterone concentrations remained between 0.42 ng and 0.67 ng/ml serum throughout the observation period. Stimulation with 5000 IU hCG/day for three days did not cause an increase in testosterone concentrations.

Aged↗

PubMed1978

[In vitro ultrasound pictures of kidney tumors].

In 5 patients with malignant renal tumours apart from in-vivo-sonogrammes ultrasound pictures of the operatively removed perfused preparations of renal tumours were additionally performed. The nephrosonogramme intracorporally showed the typical ultrasound picture of a tumour with coarsely disseminated echostructure in acoustically homogenous normal renal parenchyma. In the extracorporal sonogramme the tumour imposed as relatively echo-poor zone compared with the normal renal parenchyma with strong echos. The loss of the extracorporal turgor is discussed as cause of the reversion of the intensity of the echo pattern. In 3 other tumour-free renal preparations the acoustic reversion phenomenon of the normal renal parenchyma was confirmed in the extra-corporal renal preparation.

Adenocarcinoma↗

PubMed1978

[Monitoring the effectiveness of conservative treatment of benign prostatic hypertrophy by means of uroflowmetry].

96 patients with benign hyperplasia of the prostate and dysuric complaints in stage I and beginning stage II were treated conservatively and medicamentously up to 12 months. In the collective of patients subdivided into 4 groups the conservative therapy was carried out in 3 groups with different phyto-preparations and in one group with gestonorone capromate. The voiding of the bladder was examined by means of uroflowmetry in intervals of four weeks before and after therapy. A clear success of the effect appeared only in the group of patients treated with gestonorone capromate. With phyto-preparations uroflowmetrically no significant effect on the disturbed voiding of the bladder could be established. The conservative treatment of the benign hyperplasia of the prostate should be carried out under uroflowmetrical control, in order not to miss the time of a necessary operative intervention.

Aged↗

PubMed1976