[A study on ventricular premature contraction (VPC) by Holter ECG recordings. Regarding diurnal and day-to-day variations].
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Biomedical subjects
Publications and source records attributed to T Satoh.
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We experienced acute hemorrhagic cystitis with renal dysfunction in a recipient of a transplanted kidney. This acute hemorrhagic cystitis was caused by adenovirus type 11. Either elevation of antibody titers or isolation in urine of adenovirus type 11 was identified in six cases out of 11 in seven reports which we collected. Graft dysfunctions were complicated on seven cases out of 11 in these seven reports. These graft dysfunctions have been considered as an acute rejection, but we suggest that they may be graft nephropathy caused by adenovirus type 11 infection.
The expression of opioid receptors and GTP-binding proteins was studied in 14 pheochromocytomas. The amounts of [3H]diprenorphine bound to membranes varied from 13 to 62 fmole/mg protein, but significantly higher in adrenaline-secreting tumors than in noradrenaline-secreting tumors. None of [3H]DADLE, [125I]beta-endorphin or [3H]ethylketocyclazocine binding was correlated with [3H]diprenorphine binding. Gpp(NH)p inhibition of [3H]DADLE binding was evident in all four normal human adrenal medullae but in only 8 out of 14 pheochromocytomas. The extent of Gpp(NH)p inhibition was not correlated with the amount of pertussis toxin (PT)-sensitive GTP-binding proteins as measured by PT-catalyzed [32P]ADP-ribosylation. The present findings suggest that opioid receptors and PT-sensitive GTP-binding proteins are variously expressed in transformed chromaffin cells, pheochromocytoma.
Co-administration of MAA and CoCl2 enhanced the MAA-induced increase of hepatic microsomal gamma-GTP activity in rats. This may be explained by a fact that inhibition of MAA metabolism in hepatic microsomes by CoCl2 led to increase plasma concentration of MAA which, in turn, induction of gamma-GTP by MAA was potentiated.
4-Monomethylaminoantipyrine (MAA)-induced increase of hepatic drug metabolizing enzymes was suppressed by SKF 525-A. This may be due to the partial binding of SKF 525-A to a portion of cytochrome P-450. On the other hand, glutathione S-transferase and gamma-glutamyltranspeptidase (gamma-GTP) activities of rat liver were both induced by repeated administration of MAA in combination with SKF 525-A. In addition, under the same condition, glutathione level in rat liver was significantly decreased.
A 56-year-old man was admitted with the complaint of dysphagia. X-ray studies and endoscopy revealed a protruding tumor at the middle third of esophagus. Under the diagnosis of esophageal cancer, subtotal esophagectomy was performed. A Borrmann type I like tumor measuring 6.7 X 3.8 X 2.2 cm was identified on the resected specimen. The surface of the tumor was irregular, nodular and covered with thin compressed esophageal mucosa. The histology of the tumor was consistent with adenoid cystic carcinoma. Incidentally, small foci of invasive squamous cell carcinoma were found adjacent to this tumor. There was no lymph node or remote organ metastasis.
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In Japan CAPD in cases of renal transplantation used to be feared because of CAPD peritonitis occurring under conditions of immunosuppression. We experienced two cases of CAPD with renal transplantation. Case 1 was a 27-year-old woman who underwent living related renal transplantation on March 7, 1986 after 4 months CAPD without CAPD peritonitis. In this patient the CAPD catheter was removed on the 17th POD with a good graft function. Case 2 was a 38-year-old woman who underwent living related renal transplantation on November 8, 1985. The graft deteriorated due to acute rejection and ALG allergy. On February 1, 1986 the graft was removed after insertion of a CAPD catheter. The patient began CAPD. Therefore, CAPD was found to be a safe procedure for renal transplantation. Our policy concerning CAPD for renal transplantation is as follows: A patient should not be transplanted for 1 month after successful treatment of an episode of peritonitis. After renal transplantation the catheter is removed on completion of the transplantation procedure in cases of two haploidentical living related transplants and electively 2-12 weeks after renal transplantation in cases of one haploidentical living related transplant or cadaveric transplants. The CAPD catheter is used again when there is temporary or permanent graft failure.
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