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Biomedical subjects

T Sakurai

Publications and source records attributed to T Sakurai.

At least 883 records · Page 49Linked to original sources
PubMed1978

Antitumor activity of a new amino acid derivative, N6,N9-bis-(butyloxycarbonylaminomethyl)-L-citrulline.

Approximately 800 amino acid derivatives have been synthesized and screened in order to evaluate their antitumor activity against various transplantable rat ascites hepatomas. Among them, N6,N9-bis(butyloxycarbonylaminomethyl)-L-citrulline (A-924) was found to be highly effective against various rat ascites hepatomas. A-924, when given orally, exhibited prolongation of survival of rats implanted intravenously with ascites hepatoma cells such as AH-44, AH-66, AH-130, AH-66F, or AH-41C.

Administration, Oral↗
PubMed1977

Increased atrial contribution to ventricular filling in ischemic heart disease. Non-invasive measurement by ECG-gated radiocardiography.

1. A total of 112 subjects, including 37 controls, 43 hypertensives, 27 IHD and 5 HCM, were tested by routine RCG and ECG gated RCG. 2. The atrial contribution to ventricualar filling (c/b ratio) was measured by ECG-gated RCG and a characteristic increase was found in IHD (37.5 +/- 7.7, mean +/- s.d.) and Hypertensives (26.5 +/- 8.0) compared to controls (16.1 +/- 5.0). 3. The increase in c/b ratio and the decrease in PDdV/dt in IHD seemed to be caused by primary abnormalities in the relaxation of the ventricle. 4. ECG-gated RCG, being non-invasive method, serves useful informations in estimating ischemic heart disease especially by a quantitative analysis of the diastolic filling.

Adult↗
PubMed1977

Decreased early diastolic dV/dt in ischemic heart disease observed by ECG-gated radiocardiography.

(1) ECG-gated RCG were performed in 127 cases, among them 30 were normal controls, 35 were hypertensives, 16 were ischemic heart diseases, 8 were cardiomyopathies and the rest of 38 cases were of miscellaneous cardiac diseases. (2) ECG-gated RCG were performed consecutively after the preceding RCG. Parameters calculated from RCG and ECG-gated RCG were evaluated together in terms of the sensitivity to discriminate the ischemic heart diseases from the control subjects. Among the parameters evaluated, peak diastolic dV/dt was the most sensitive index to discriminate the ischemic heart group from the control group. PDdV/dt of 20 ml/100 msec/m2 was considered to be a borderline between two groups. (3) Principal component analysis of 12 variables in 127 cases demonstrated that the peak diastolic dV/dt was closely correlated with the cardiac pump function, but was also well related to the ischemic heart factor. (4) ECG-gated RCG following the preceding RCG is a sensitive method to discriminate the ischemic heart disease from the control group.

Adult↗
PubMed1976

Mild variant of maple syrup urine disease.

Amino acids analysis were made on serum and cerebrospinal fluid samples of a Japanese 5-month-old infant suffering from irritability and mental retardation noticed at 2 months of age. Excessive amounts of branched-chain amino acids and of keto acids were detected in those samples and the large quantity of keto acids was found in urine with a qualitative 2,4-dinitro-phenyl-hydrazin test and with quantitative estimation. When thiamine hydrochloride (100 mg/day) was administered orally for 7 days to the patient fed with the cow's milk formula containing 2.1 gm/dl milk protein, there was no improvement of the branched-chain amino acidemia. Urinary keto acids, however, showed a marked decrease 7 days after the administration of thiamine hydrochloride. An overnight fast for 13 h resulted in normoglycemia. There was found no difference of blood L-lencine level between both parents and normal infants to whom L-leucine was loaded. The relation between decarboxylase activity for keto acids of branched-chain amino acids and thiamine hydrochloride was studied clinically, in the present communication.

Amino Acids↗
PubMed1976

Fibrinogen/fibrin degradation products in serum of patients with idiopathic thrombocytopenic purpura: elevated levels during severe thrombocytopenic phase of the disease.

Sera from 23 patients with idiopathic thrombocytopenic purpura (ITP), 14 patients with aplastic anemia with severe thrombocytopenia and healthy control subjects were tested for the presence of fibrinogen/fibrin degradation products (FDP), using the tanned red cell hemagglutination inhibition immunoaassay. The concentrations of circulating FDP of ITP patients (mean 12.01 mug/ml) were significantly higher than those of the patients with aplastic anemia (mean 4.01 mug/ml, p less than 0.05) or normal controls (mean 3.10 mug/ml, p less than 0.001). The patients with untreated ITP with very low platelet counts had higher levels of FDP than those of the treated group (p less than 0.01). Serum FDP and a battery of other coagulation-fibrinolysis tests were serially carried out over a period of 10 weeks in two patients with ITP. The initially high FDP promptly decreased as circulating platelets increased in response to steroid in both patients, while plasma fibrinogen, euglobulin lysis time, prothrombin time and partial thromboplastin time remained essentially normal during the course of observation. The exact source of the increased serum FDP in ITP was not established, but a few possible mechanisms responsible for this abnormality were discussed.

Acute Disease↗