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Biomedical subjects

T Sacks

Publications and source records attributed to T Sacks.

At least 73 records · Page 4Linked to original sources
PubMed1976

Chronic bacterial prostatitis: new therapeutic aspects.

6 cases with chronic bacterial prostatitis were reviewed. The effort and patience required to diagnose this condition accurately by means of differential urine and prostatic secretion cultures is extremely worthwhile. Cotrimoxazole, which has been suggested as a most effective antibacterial drug in chronic bacterial prostatitis, cured only 3 out of our 6 patients and then only after continuous treatment for 4 months. 2 of the remaining patients were cured by a 10 to 14 days' course of kanamycin and the third was probably cured by streptomycin. On theoretical grounds neither of these lipid insoluble drugs should be capable of penetrating the prostatic epithelium. The implications of these findings are discussed.

Adult↗
PubMed1975

Postoperative ventriculitis in infants.

Eight consecutive cases of ventriculitis detected and treated during a four year period are reviewed. This complication represented 7.9% of all cases of spina bifida treated surgically, and 5.4% of all shunt precedures performed during the study period. Prophylactic antibiotic treatment did not reduce the incidence of ventriculitis, and in fact seemed to produce resistant strains, which led to difficulties in treatment and a worse prognosis. The presence of an intraventricular foreign body precludes permanent sterilization of the ventricular fluid. Finally, in those cases in which the antibiotic of choice penetrates poorly into the cerebrospinal fluid; intraventricular as well as systemic administration of the drug is indicated. With Gram negative organisms, Gentamicin is currently the drug of choice.

Cerebrospinal Fluid↗
PubMed1975

Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: distribution of biochemical risk factors.

Distributions of serum cholesterol, glucose, uric acid and triglycerides are examined among Japanese men living in Japan, Hawaii and California. Laboratory methods are described in detail and efforts to assure comparability of these methods. In every age group studied, the mean, median and percentile for each of the biochemical variables are lower for men in Japan than in Hawaii and California.

Aged↗
PubMed1975

Infection in war wounds: experience during the 1973 October War in Israel.

The development of infections in 420 wounded soldiers, admitted to the Hadassah University Hospital in Jerusalem between October 7, 1973 and November 31, 1973, was studied. An attempt was made to relate the development of infection to the type of injury. The overall infection rate was 22%, but varied with the type of injury. Three "risk factors" were found to be associated with infection regardless of the number of injuries: 1)penetrating abdominal wounds involving the colon; 2) fractures involving the femur; 3) burns involving more than 25% of body surface. In patients with comparable injuries, the presence of infection was found to prolong the duration of hospitalization. Pseudomonas was the most common single pathogen. There were no cases of myonecrosis (gas gangrene). Of the 8 soliders who died, 5 died with or because of infection.

Adult↗
PubMed1975

Mechanis of chlorampenicol-cephalordine synergism on Enerobacteiaeae.

A synergistic in vitro bactericidal effect of combinations of chloramphenicol and beta-lactams on strains of Enterobacteriaceae is described. The synergism is seen with strains which are resistant to the beta-lactam and is due to chloramphenicol-induced inhibition of beta-lactamase production.

Cephaloridine↗
PubMed1975

Penetration of parenterally administered gentamicin into the cerebrospinal fluid in experimental meningitis.

The penetration of parenterally administered gentamicin into the CSF was examined in dogs. The experiments were carried out in three stages: (1) in healthy dogs, (2) in dogs with meningitis, and (3) during recovery from the acute inflammation. Gentamicin was found to penetrate poorly into the CSF, reaching mean peak levels of 0.7 mug/ml in healthy dogs. During the height of the meningeal inflammation the mean peak gentamicin level in the CSF was 0.9 mug/ml. The ratio of mean maximum CSF to mean maximum serum levels of gentamicin was 5.8% in healthy dogs, and 11.3% in dogs with meningitis. Thus, inflammation increases the penetration of parenterally administered gentamicin into the CSF, but therapeutically adequate levels for gram-negative bacillary meningitis are not achieved.

Animals↗
PubMed1973

Bactericidal effect of combinations of nalidixic acid and various antibiotics on Enterobacteriaceae.

The activity of nalidixic acid combined with each of 10 other antimicrobial agents on 95 strains of Enterobacteriaceae was studied. Synergism was found less often than antagonism, and the commonest outcome was indifference. Combinations of nalidixic acid with kanamycin, gentamicin, or colistin were more often synergistic than antagonistic, whereas with the other antibiotics the combination was more often antagonistic than synergistic. Synergistic effects were more common with Shigella than with other genera. In vitro examination for synergism or antagonism appears to be advisable before nalidixic acid is used therapeutically in combination with other antimicrobial agents.

Anti-Bacterial Agents↗