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Biomedical subjects

T Paul

Publications and source records attributed to T Paul.

At least 163 records · Page 9Linked to original sources
PubMed1978

Phenylalanine depletion for the management of phenylketonuria: use of enzyme reactors with immobilized enzymes.

Multitubular enzyme reactors with immobilized phenylalanine ammonia lyase were tested in vitro and in vivo for depletion of phenylalanine in circulating blood. Sustained reduction of phenylalanine was achieved in less than 30 minutes. A 50% decrease of phenylalanine was obtained with a 2-hour application of enzyme reactors and was maintained for more than 2 days. Similar enzyme reactors have therapeutic potential for temporary management of phenylketonuric patients when their circulating phenylalanine becomes exceedingly high because of infection, fever, or pregnancy.

Ammonia-Lyases↗
PubMed1977

Phase 1 tolerability and searching dose studies with 4-isothiocyanato-4'-nitrodiphenylamine (C.9333-Go/CGP 4540), a new anthelmintic.

1 Phase 1 and 2 studies were carried out in thirteen volunteers and thirty patients with hookworm anaemia with a new anthelmintic, 4-isothiocyanato-4'-nitrodiphenylamine (C.9333-Go/CGP 4540). Single and multiple doses were administered by mouth under careful supervision by the staff of the clinical pharmacology unit. 2 4-Isothiocyanato-4'-nitrodiphenylamine (C.9333-Go/CGP 4540) was well tolerated in volunteers up to a single dose of 1750 mg and in patients up to 3000 mg in divided doses. Side effects were rare, transient and mild. One patient had moderate giddiness for 24 h after the compound. The laboratory investigations did not show any adverse effects on organ functions. Transient non-specific changes in the T-wave were occasionally observed in the e.c.g. 3 Multiple doses (125 mg, 250 mg or 1000 mg X 3) of the compound were highly effective in eradicating hookworm infection, as judged by almost 100% reduction in faecal egg counts and significant recovery of parasites from 24 h stool samples. The compound also showed activity against A. lumbricoides, T. trichiura and E. vermicularis. The compound appears to be promising and more studies, in a field situation, are desirable.

Adolescent↗
PubMed1977

[Significance of contemporary methods of lung function testing for the detection of airway obstruction in children and adolescents (author's transl)].

In the article we outlined the basic principles of some recent methods of lung function testing, suitable for the assessment of airway obstruction in children and adolescents. There is also a brief description of various methods, normal values expressed in a form of regression equations, significance of different methods for the assessment of airway obstruction in patients with respiratory diseases and in children from a region with increased levels of air pollution. Among the various functional indices we found the most sensitive for the assessment of airway obstruction maximum expiratory flow rates measured at lower lung volume levels. Airway conductance appeared as the most sensitive method for the evaluation of bronchodilation following inhalation of some drugs. The measurements of airway conductance in a body plethysmography during normal quiet breathing and of maximum expiratory flow rates from flow-volume curves represent the basic methods for the detection of airway obstruction, i.e. in the larger central airways, and in the peripheral airways respectively.

Adolescent↗
PubMed1976

Pulmonary elasticity in children and adolescents.

Static (Cst(L)), dynamic (Cdyn(L)), and "specific lung compliance (CL/TLC, CL/FRC) and the elastic recoil pressure of the lungs (Pst/(L)) were measured in 131 healthy children and the adolescents (age 6 to 17 years) from simultaneous recordings of esophageal pressure and lung volume. Esophageal elastance and vertical esophageal pressure gradients were also studied. Pst(L), measured at different lung volumes (fractional) from the expiratory quasi-static pressure-volume (PV) curves of the lungs, increased significantly with increasing body height, age, and body surface. Cst(L), determined from the midportion of PV curves, and Cdyn(L) measured during normal breathing at frequencies around 20/min also increased significantly with somatic growth. "Specific" Cst(L) decreased with increasing body height, age, and body surface. "Specific" Cdyn(L), esophageal elastance, and the vertical esophageal pressure gradient were independent of body height, age, and body surface, Cdyn(L) was less than Cst(L) mainly in smaller and younger children, and was not considered a valid index of pulmonary elasticity. Values of Pst(L), "specific" Cst(L), and the change of slope of the midportion of PV curves in children and adolescents suggested developmental changes of pulmonary elasticity in man over the age range studied.

Adolescent↗