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Biomedical subjects

T Paul

Publications and source records attributed to T Paul.

At least 145 records · Page 8Linked to original sources
PubMed1984

The retailing of health care.

A number of striking parallels between recent developments in health care marketing and changes in the retailing industry exist. The authors have compared retailing paradigms to the area on health care marketing so strategists in hospitals and other health care institutions can gain insight from these parallels. Many of the same economic, demographic, technological and lifestyle forces may be at work in both the health care and retail markets. While the services or products offered in health care are radically different from those of conventional retail markets, the manner in which the products and services are positioned, priced or distributed is surprisingly similar.

Ambulatory Care Facilities↗
PubMed1983

Phase 1 tolerability and antiamoebic activity studies with 1-methylsulphonyl-3-(1-methyl-5-nitro-2-imidazolyl)-2-imidazolidinone (Go.10213): a new antiprotozoal agent.

Go.10213, a new nitroimidazole, was studied in 12 male volunteers for tolerability and in 20 patients with intestinal amoebiasis for antiamoebic activity. Go.10213 was well-tolerated by volunteers up to a dose of 400 mg X 3. Patients also tolerated well the dose of 100-150 mg X 3 for 7 days. In two patients, there were mild and transient side-effects like headache, dizziness, fatigue, etc. No neurological side-effects were observed. There were no significant changes in blood pressure, pulse rate and ECG. The organ function tests did not show any adverse effects of Go.10213 on bone-marrow, kidney, liver, etc. Go.10213, at a dose of 150 mg X 3, showed potent antiamoebic activity in 10 patients with intestinal amoebiasis, as judged by the clinical relief, the eradication of the trophozoites and cysts of Entamoeba histolytica from stools and the healing of colonic ulcers. Go.10213, a novel nitroimidazole, may prove to be the most potent and safe agent against the protozoal infections, e.g. amoebiasis, giardiasis and trichomoniasis.

Adolescent↗
PubMed1983

Temporary depression of lactase activity by thyroxine in suckling rats.

The present study was performed in order to clarify controversies concerning the effect of thyroxine on lactase activity in young mammals. Lactase activity was determined in suckling rats with two reference systems (protein and DNA) after one and three thyroxine injections (0.2 mg/100 g body weight). In comparison with control animals lactase activity was decreased after thyroxine administration. The thyroxine effect was dosage-dependent: three injections caused a more profound and prolonged depression of lactase activity. In both thyroxine-treated groups lactase activity returned to age-specific normal levels before the low lactase activity of adult rats was attained. The transient thyroxine-induced changes of lactase activity were similar to the reference parameters protein and DNA.

Animals↗
PubMed1983

A comparative study of centbucridine and lidocaine in dental extraction.

A randomized double-blind study comparing the efficacy and tolerability of centbucridine (0.5%) with those of lidocaine (2%) as an anaesthetic agent was conducted in the dental outpatient department on patients attending for dental extraction. One hundred and twenty patients were studied. The degree of analgesia attained with centbucridine compared well with that obtained with lidocaine. The compound was well tolerated with no significant changes in the cardiovascular parameters and no serious side-effects.

Adolescent↗
PubMed1980

Plasma levels of trimethoprim and sulfonamide after administration of trimethoprim-sulfamethoxazole and trimethoprim-sulfamoxole.

In a cross-over study with ten healthy volunteers, the plasma levels of trimethoprim (TMP) and sulfonamides were compared using orally given trimethoprim-sulfamethoxazole (TMP-SMX: Septra) and trimethoprim-sulfamoxole (TMP-SMO: Supristol) in recommended doses. The dosage schedule for TMP-SMX was 2 tablets every 12 h for nine doses, and for TMP-SMO it was 2 tablets as in the first dose, followed by 1 tablet every 12 h for eight more doses. Serial plasma levels of TMP and sulfonamides after the first dose of each of the two products showed no significant differences. However, after the ninth dose of each product, the paired t test revealed significantly higher levels of TMP and sulfonamides after TMP-SMX as compared with TMP-SMO.

Adult↗
PubMed1979

Comparative effects of imipramine and dothiepin on salivary rate in normal volunteers.

1 Imipramine induced significant reduction in salivary rate compared to placebo in a cross-over, double-blind study of twelve normal volunteers. In contrast, there was no significant difference between the reduction in salivary rate induced by dothiepin and placebo. 2 Comparison of salivary rates showed no significant difference between the drugs in the initial and cross-over treatment periods. However, pooled observations from the initial and cross-over treatment periods indicated that imipramine produced a significantly greater reduction in salivary rate than dothiepin. 3 The results suggest that dothiepin would cause far less dryness of mouth compared to imipramine. This feature might ensure greater therapeutic compliance.

Dibenzothiepins↗