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Biomedical subjects

T Palosuo

Publications and source records attributed to T Palosuo.

At least 163 records · Page 9Linked to original sources
PubMed1976

A ubiquitous tissue antigen and its corresponding antibody in sera of patients with glomerulonephritides.

Sera and 5% PEG-precipitates from 20 patients with IMN, 18 with MPGN, 20 with SLE, 8 with anti-GBM disease and 17 with other varieties of glomerulonephritides, 19 patients with chronic liver or intestinal diseases, as well as those from 40 healthy adults, were tested by gel prcipitation for the presence of a ubiquitous tissue antigen (UTA) and/or its corresponding antibody, previously shown to be associated with renal disorders. The antigen was detected in sera of 5 patients with IMN, one with anit-GBM disease and one with SLE. Corresponding antibodies were present in sera of 2 patients with IMN. In 4 of 5 patients with IMN and UTA was only detected if the sera were first treated with PEG (mol. wt. 6,000) which induces precipitation of antigen-antibody complexes and other high molecular weight components in serum. The UTA was not detected in renal glomeruli by immunofluorescence. The possible significance of these findings in the pathogenesis of renal diseases is discussed.

Antibodies↗
PubMed1976

Gold nephropathy: serologic data suggesting an immune complex disease.

Servlogical tests preformed on a patient with gold-induced nephropathy revealed a multitude of immunological phenomena preceding the onset of proteinuria. These included formtaion of tissue antibodies, rheumatoid factors and circulating immune complexes. An antigen sharing immunological determinants with DOC-extractable tissue antigens was released into circulation before and during proteinuria. Precipitating antibodies against this circulating antigen were found in one serum sample obtained 6 weeks before the complication was diagnosed. In this serum specimen, antibodies were also found which combined with saline extracts, DOC extracts containing the ubiquitous tissue antigen (UTA), and preparations obtained from various human organs by extraction at 100 degrees C followed by precipitation at 71% ethanol concentration (BE preparations). Most of the activities disappeared before the onset of proteinuria. The possible significance of these phenomena in the pathogenesis of nephropathy is discussed.

Adult↗
PubMed1975

Platelet aggregation by isolated and aggregated human IgG.

Isolated myeloma proteins of the four human IgG subclasses, aggregated by heat of bis-diazotized benzidine (BDB), induced aggregation of human platelets (Pl.A.) demonstrable by the sedimentation pattern test. With this sensitive technique, approximately 0-1 mug/ml of BDB-aggregated IgG1 and IgG3 could be detected whereas 200 to 1000 times higher concentrations of IgG2 and IgG4 were required for the Pl.A. reaction. The reaction pattern showed similarities with complement fixation tests.

Benzidines↗
PubMed1970

Protection of man from natural infection with influenza A2 Hong Kong virus by amantadine: a controlled field trial.

Prophylactic administration of amantadine in doses of 100 mg. twice a day offered statistically significant protection against influenza A2 infection in a double-blind field trial involving 391 medical student volunteers during the influenza A2 Hong Kong epidemic in Helsinki in the winter of 1969. Serologically verified influenza, as measured by complement fixation and/or haemagglutination inhibition, occurred in 27 out of 192 students in the amantadine group against 57 out of 199 in the placebo group, giving a protection rate of 52%.

Adult↗
PubMedDate not supplied

Anticardiolipin response in Kawasaki disease.

Antibodies against cardiolipin are formed in many different infectious diseases, and high levels are associated with susceptibility to thrombosis, especially in patients with systemic lupus erythematosus. In view of the postulated infectious etiology of Kawasaki disease an its association with thrombosis, we have studied the occurrence of anticardiolipin antibodies in this disease. Serial serum specimens from 36 patients were tested, using a solid-phase enzyme immunoassay. A change of at least 0.3 optical density units between two consecutive specimens for at least one immunoglobulin class was observed in 47% of cases. Peak levels occurred one to two weeks after the onset of symptoms. Four patients developed coronary artery aneurysms, and they all showed a clear anticardiolipin response. Anticardiolipin antibodies might be one factor contributing to coagulation abnormalities in patients with Kawasaki disease.

Autoantibodies↗
PubMedDate not supplied

Humoral immune response to mammalian allergens.

Solid-phase enzyme immunoassay and passive hemagglutination were used to study the occurrence of antibodies of various isotypes against feline and bovine epithelial extracts in RAST-positive patients, exposed subjects (cat fanciers and senior veterinary students) and healthy controls. A high proportion of the patients had positive results, whereas the findings in exposed subjects varied, depending on the antigen and test technique. These observations caution against making far-reaching conclusions on the basis of narrow studies.

Allergens↗
PubMedDate not supplied

Detection of IgG4 and IgE antibodies to rubber proteins by immunoblotting in latex allergy.

Sera from four latex-allergic hospital employees (two physicians and two nurses) were examined for the occurrence of IgG4 and IgE antibodies to rubber proteins by immunoblotting. We used natural rubber sap as antigen source and detected IgG4 antibodies in all four patient sera. The IgG4 antibodies bound to 12 rubber protein antigens with molecular weights ranging from 14 kD to 53 kD. IgE antibodies bound nine of the antigens and the major antigen for both IgG4 and IgE seemed to be a 21 kD rubber protein. The parallel occurrence of IgG4 and IgE antibodies against the same rubber protein antigens suggests that IgG4 antibodies also may play a role in the pathogenesis of latex allergy.

Antigens↗