Search PubMed⌕ Search

Biomedical subjects

T Osada

Publications and source records attributed to T Osada.

At least 217 records · Page 12Linked to original sources
PubMed1985

[Clinical studies on doxycycline in male nongonococcal urethritis].

Doxycycline (DOXY) was administered to 45 male patients with nongonococcal urethritis. The dose was 200 mg b.i.d. and the duration of administration was 14 consecutive days in principle. The results were as follows: C. trachomatis was detected from urethral swab by culture confirmation test and/or direct specimen test. Of 45 patients with nongonococcal urethritis, 25 were positive with C. trachomatis. The positive rate was 56%. In the C. trachomatis positive group, the clinical efficacy was excellent in 15 patients, and fair in 4 out of 19 patients which could be studied about the clinical effect after administration. The total efficacy rate was 79%. The efficacy in 11 patients of the C. trachomatis negative group was excellent in 7 patients and fair in 4, the total efficacy rate being 64%. Microbiologically, inclusion bodies disappeared in 7 days of administration in all 9 patients which were positive with C. trachomatis by culture confirmation test. In 19 patients which were positive by direct specimen test, elementary bodies of C. trachomatis disappeared within 7 days in 13 patients (76%) and within 14 days in all patients. As to side effect, mild epigastralgia was observed in 1 patient, but medication could be continued when the dose of DOXY was reduced by half. Clinical laboratory tests were investigated in 15 patients before and after administration and no abnormal alteration was observed.

Administration, Oral↗
PubMed1983

New intraoral x-ray fluorographic imaging for dentistry.

A new dental x-ray fluorographic unit has been developed. This unit is composed of small intraoral x-ray tube, a compact x-ray image intensifier, and a high-resolution TV system. The purposes for developing this equipment were to (1) directly observe the tooth during endodontic procedures and (2) reduce x-ray exposure to the patient and the dentist. The radiation exposure can be reduced to about 1/600 the exposure used with conventional dental film. In clinical trials, a satisfactory fluorographic dental image for endodontic treatment was obtained with this new device.

Humans↗
PubMed1983

Normalizing effects of plasma on altered cation transport of red blood cells from essential hypertensive patients.

Net Na+ and K+ fluxes were measured in Na+-loaded red cells from 19 normotensive control subjects, 22 essential hypertensive patients, and 8 secondary hypertensive patients. The ratio of Na+/K+ net fluxes was significantly lower in essential hypertensive patients than in normotensive control subjects. However, by the addition of the patients' own plasma, the net Na+ efflux rate was significantly increased in essential hypertensive patients, which caused the increment in the ratio of Na+/K+ net fluxes. This resulted in disappearance of the difference between normotensive and hypertensive subjects in the ratio of cation fluxes. It was possible that the abnormalities of cation transport in red cells from essential hypertensive patients might be compensated for by humoral factors in the plasma.

Adolescent↗
PubMed1983

Cation transport of red blood cells from hypertensive patients in Japan.

This study was performed to determine whether there is any difference in cation transport of red blood cells from normotensive subjects and hypertensive patients in Japan. Net Na+ efflux and net K+ influx rates were measured in sodium-loaded red cells from 19 normotensive subjects, 22 essential hypertensive patients, and 8 secondary hypertensive patients. The ratio of Na+/K+ net fluxes and the net cation flux rate were compared between these groups. The ratio of Na+/K+ net fluxes was significantly lower in essential hypertensive patients than in normotensive subjects. Parameters such as age, sex, blood pressure, plasma renin activity, and plasma aldosterone concentration were also examined in 2 groups of essential hypertensive patients, divided on the basis of their Na+/K+ net fluxes. However, there is no significant difference between the groups. These results suggest that the ratio of cation flux is related to hypertension independently of these parameters.

Adolescent↗
PubMed1983

[Intrathoracic administration of adriamycin with closed tube thoracostomy drainage for malignant pleuritis: observation on the administration dosage].

The effect of intrathoracic administration of adriamycin with closed tube thoracostomy drainage was investigated on patients with various malignant pleural effusions (13 lung cancer and one each stomach, breast, ovarian cancer, respectively). The doses of adriamycin ranged from 50, 30, 20, to 10 mg given to four groups of 4 cases respectively. Comparative study on effective rates, survival period after the administration, side effects and histopathological changes in autopsied cases was performed. The results obtained were as follows: 1. With regard to effective rates and histopathological changes, no difference was observed in the four groups in term of dose escalation of Adriamycin. 2. 50% survival period was similar within the groups administered 20, 30 and 50 mg of Adriamycin. However, the group receiving 10 mg showed slightly shorter survival period. 3. Although serious side effects were not observed in any groups, minor toxicities were mostly encountered in the 50 mg group. 4. It was concluded that in the treatment of malignant pleural effusion, an appropriate dose of intrathoracic administration of adriamycin was about 20-30 mg.

Adenocarcinoma↗