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Biomedical subjects

T Ogino

Publications and source records attributed to T Ogino.

At least 289 records · Page 16Linked to original sources
PubMed1988

Histological analysis of myleran induced oligodactyly of longitudinal deficiency in rats.

In this study, tibial ray deficiency was used as a model of longitudinal ray deficiency and the pathogenesis of the oligodactyly of longitudinal ray deficiency was investigated. Tibial ray deficiency was induced in rat fetuses by a single oral administration of myleran to pregnant rats on day 10 of pregnancy. The dose of myleran administered was 40 mg/kg of body weight. In order to observe the process of formation of the foot plates and digital rays of tibial ray deficiency, histological examination was done. The period of development studied was from day 12 to 16 of pregnancy. A series of fetuses was surgically removed from their mothers at 12 hours' interval. Histological examinations of the hind limbbuds and foot plates were performed quantitatively. The formation of hind limbbuds was detected on day 12 in myleran treated group as in control group. The formation of digital rays in the myleran treated group was initially observed on day 14.5, 12 hours later than control. The size of hind limbbuds and the density of mesenchymal cells in hind limbbuds treated by myleran was smaller than control and the hypoplasia of the limbbuds was maximum on day 14. The shape of foot plates treated by myleran was asymmetrical compared with the symmetrical limbbuds in controls. Concerning tissue damage in limbbuds, dead cells of ectoderm were distributed on the top of the limbbuds on day 12 and they disappeared 24 hours later. On the other hand, dead cells of mesenchyme were scattered in hind limbbuds on day 12.(ABSTRACT TRUNCATED AT 250 WORDS)

Abnormalities, Drug-Induced↗
PubMed1988

[An autopsy case of parotid clear cell carcinoma with cerebellar invasion and metastasis to the lung].

An autopsy case of a clear cell carcinoma of the salivary gland with a cerebellum invasion and a metastasis to the lung is reported. This case has been classified as a monomorphic variant, although we were unable to demonstrate the presence of glycogens in the cytoplasm of the tumor cells. Ultrastructurally, most of the proliferating cells were immature cells with few organelles. The tumor cells were unable to be differentiated into ductal cells and myoepithelial cells. Recently, the tumor has been determined to be a low grade malignancy. Obviously, this tumor had a malignant character, with a cerebellum invasion and a metastasis to the lung.

Adenocarcinoma↗
PubMed1988

Clinical and experimental studies on ulnar ray deficiency.

Thirteen cases with ulnar ray deficiency and thirty-three cases with radial ray deficiency were analysed. The differences of these two anomalies are not only affected parts, but also clinical features. The severity of absence of the fingers in ulnar deficiency was classified into five types. The degree of ulnar arrest was closely related to the severity of deficiency of the fingers and also to abnormalities of the elbow joint. Ulnar deficiency was induced by myleran in rat fetuses. The features of ulnar ray deficiency in rats were the same as in humans. The critical period of ulnar deficiency was earlier than that of other anomalies and it corresponds to the period of a high mortality rate of fetuses. This could be the reason why ulnar deficiency does not appear as often as other anomalies.

Abnormalities, Multiple↗
PubMed1987

Free vascularized fibular grafts in the treatment of congenital pseudarthrosis of the tibia.

Five patients with congenital pseudarthrosis of the tibia treated by a free vascularized fibular graft are described. Follow-up evaluation ranged from 15 to 81 months, with a mean of 40 months. Bony union was attained in three of five cases as determined roentgenographically. The remaining two cases failed to attain bony union. All cases except one, who was treated with a below-knee amputation, subsequently attained bony union. However, four cases had five fractures after bony union. We discussed unsolved problems regarding the free vascularized fibular graft and fracture after bony union.

Child↗
PubMed1987

Congenital radio-ulnar synostosis: compensatory rotation around the wrist and rotation osteotomy.

In order to make clear the clinical features of congenital radio-ulnar synostosis, compensatory rotation around the wrist and functional results after rotation osteotomy, 40 cases of congenital radio-ulnar synostosis have been analysed. The mean pronation of the ankylosed forearm in those who complained of disabilities in daily life was 60.7 degrees and that in patients without complaints was 21.2 degrees. In almost all cases with total ankylosis, the forearm had compensatory movement around the wrist, the mean arc being from 76.3 degrees of pronation to 42.9 degrees of supination. 13 limbs in 11 patients treated by transverse rotational osteotomies through the fusion mass have followed up for over two years. The functional results after surgery were satisfactory in all patients. Rotational osteotomy of the forearm is a useful and reliable treatment for congenital radio-ulnar synostosis.

Adolescent↗
PubMed1987

Congenital constriction band syndrome and transverse deficiency.

To distinguish the clinical features of amputation due to congenital constriction band syndrome from those of transverse deficiency, 42 cases of constriction band syndrome and 27 cases of transverse deficiency were analysed. All the transverse deficiencies were unilateral. Two cases of transverse deficiency were associated with pectoral muscle absence, whereas amputation from constriction band syndrome was often associated with similar anomalies in other parts of the body. The level of amputation of transverse deficiency was more proximal than that of constriction band syndrome. Rudimentary fingers and/or nails were common in transverse deficiency but there were few in constriction band syndrome. Various degrees of bone hypoplasia existed in adjacent fingers or in a proximal part of the affected limb in transverse deficiency, but there were no such findings in constriction band syndrome.

Amniotic Band Syndrome↗
PubMed1987

Nonunion of the capitate.

A case of nonunion of the capitate of a 13-year-old girl is reported. Autogenous iliac bone grafting obtained union. At the 2-year follow-up, she had no complaints and had full motion of the wrist.

Adolescent↗
PubMed1987

Carpal tunnel syndrome in patients undergoing hemodialysis.

We treated 20 cases of carpal tunnel syndrome is 12 patients who were undergoing hemodialysis therapy for chronic renal failure. In all patients the arm involved had been used for a fistula. There was no correlation with the renal diagnosis and the duration of hemodialysis therapy. The cause of the syndrome has been debated; however, one factor does not give rise to symptoms of carpal tunnel syndrome. All of the factors discussed in this article, acting in concert, may be causes of carpal tunnel compression. Surgical intervention successfully relieved all symptoms.

Adult↗
PubMed1987

Treatment of distal radioulnar disorders.

Twenty-nine wrists of 29 patients were treated with three procedures: distal ulnar resection (Darrach's procedure), distal ulnar recession, or hemiresection-interposition arthroplasty. The indications were pain and limitation of motion associated with primary osteoarthritis of the distal radioulnar joint, derangement after distal forearm bone fracture, Madelung's deformity, and distal radioulnar sprain. The age of the patients averaged 48.3 years. Follow-up averaged 1 year and 9 months. Radiographic evaluations were done preoperatively and postoperatively. Relief of pain was good in the wrists treated by Darrach's procedure; however, diminished grip strength and wrist instability occurred. Relief of pain in the wrists treated by distal ulnar recession and hemiresection-interposition arthroplasty was inferior to that of Darrach's procedure; however, postoperative grip strength increased and wrist instability did not occur.

Female↗
PubMed1987

Treatment of the West syndrome with high-dose pyridoxal phosphate.

Fifteen (12.7%) among 118 cases of the West syndrome were effectively treated by high-dose pyridoxal phosphate (PAL-P). 1) Clinical seizures were completely suppressed in 12 cases with PAL-P alone, and in 3 cases by an addition of PAL-P to the previously poorly-effective regimen. At the follow-up, 12 cases have continued to be free from seizures, while two cases relapsed into the Lennox-Gastaut syndrome, and one died. 2) Electroencephalographically hypsarhythmia disappeared by PAL-P in all 15 effective cases. 3) Effective daily dose of PAL-P was 30 to 400 mg. 4) Notably, PAL-P was effective even in the cases with obvious organic brain pathology, such as tuberous sclerosis, porencephaly, holoprosencephaly, postmeningitis, besides 5 idiopathic cases. 5) Efficacy of PAL-P was significantly higher in idiopathic cases than symptomatic cases; 35.7% vs 9.6%. 6) Response to PAL-P was not predictable by any laboratory data nor clinical features. 7) Prognosis of PAL-P responsive cases was favorable; as many as 6 cases developed normally among 14 cases followed-up. Treatment with a high-dose PAL-P should be tried in all cases of the West syndrome at first.

Administration, Oral↗
PubMed1987

Measurement of Na+-K+ coupling ratio of Na+-K+-ATPase in rabbit proximal tubules.

A combination of 23Na nuclear magnetic resonance (NMR) spectroscopy and a K+-selective electrode was used to make simultaneous measurements of net Na+ and K+ fluxes across plasma membranes of rabbit renal proximal tubules after an abrupt stimulation of Na+-K+-ATPase. After a step in extracellular K+ concentration ([K+]o) from low to higher concentration (0.1-0.3 mM to 0.5-5.2 mM) at 25 degrees C, net extrusion of Na+ and uptake of K+ were observed. These fluxes were completely inhibited by ouabain (10(-3) M). Because initial rates of K+ uptake in presence or absence of Ba2+ (a known inhibitor of plasma membrane K+ conductance) were indistinguishable, net K+ flux was virtually unidirectional. Because suspension buffers contained neither glucose nor amino acids and the ratio of net Na+ and K+ fluxes (JNa and JK, respectively) was constant over a wide range of transmembrane Na+ gradients and absolute values of the JNa and JK, it is likely that changes in electrogenic or passive net fluxes across plasma membranes were insignificant in the first 30-45 s after the [K+]o step. Thus the ratio of these initial net Na+ and K+ fluxes corresponds closely to the Na+-K+ coupling ratio of the Na+-K+-ATPase. In 12 experiments, the measured Na+-K+-ATPase coupling ratio was 1.54 +/- 0.07 (SE). The coupling ratio was constant over a wide range of intracellular Na+ content, intracellular sodium concentration, [K+]o and transmembrane Na+ gradient. The coupling ratio also remained constant over an eightfold range of Na+-K+-ATPase rates.

Animals↗
PubMed1987

Distribution of alpha-fetoprotein-producing cells and proliferating cells in human hepatoma cells transplanted into athymic mice.

To clarify the relationship between alpha-fetoprotein (AFP) production and cell growth in hepatocellular carcinoma an immunohistochemical method was used to examine the geographical distribution of AFP-producing cells and DNA-synthesizing cells in hepatoma tissue which was formed by subcutaneous transplantation of the human hepatoma cell line, HuH-7, into athymic mice. DNA-synthesizing cells were localized to the perivascular restricted areas where AFP-producing cells were preferentially demonstrated. The fall of the labeling index of bromodeoxyuridine was accompanied by a decrease in AFP production. The results indicate that AFP is produced mainly by the cells participating in tumor growth but not by quiescent cells.

Animals↗