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Biomedical subjects

T Ogino

Publications and source records attributed to T Ogino.

At least 271 records · Page 15Linked to original sources
PubMed1988

Hepatocellular carcinoma arising in the abdominal cavity. An autopsy case of ectopic liver origin.

An unusual case of extrahepatic disseminating hepatocellular carcinoma in a 64-year-old man is reported. The initial symptom was abdominal fullness and progressive ascites. Alpha-fetoprotein in the serum was 117,000 ng/ml. Exploratory laparotomy disclosed dissemination of tumor nodules throughout the abdominal cavity without any other possible primary tumor. CT scan, ultrasonography and hepatic angiography were unable to detect any tumor lesion in the liver. The final histologic diagnosis was hepatocellular carcinoma, although at first epithelioid mesothelioma was suspected. The present case of hepatocellular carcinoma was thought to have possibly developed from ectopic liver on the peritoneum.

Abdominal Neoplasms↗
PubMed1988

High-resolution proton magnetic resonance spectroscopy of rabbit brain: regional metabolite levels and postmortem changes.

The changes in 16 cerebral metabolites produced by cardiac arrest and subsequent room temperature autolysis were studied using high-resolution proton nuclear magnetic resonance spectroscopy. Biopsies of rabbit cerebral cortex, cerebral white matter, and cerebellum were quantitatively analyzed for acetate, alanine, gamma-aminobutyric acid, creatine, glutamate, glycine, inositol, lactate, N-acetylaspartate, phosphocreatine, succinate, taurine, and threonine. Of these, N-acetylaspartate and the total creatine pool are the best candidates for use as concentration reference standards linking in vitro to in vivo 1H nuclear magnetic resonance measurements. Both changed little immediately after death, and they varied in a distinctive way among cortex, white matter, and cerebellum.

3-Hydroxybutyric Acid↗
PubMed1988

Application to forensic odontology of aspartic acid racemization in unerupted and supernumerary teeth.

Racemization of aspartic acid in dentin protein during the human lifetime progresses with age. The extent of racemization of aspartic acid in coronal dentin of normal permanent teeth can be used in forensic odontology to estimate the age of an individual at the time of death (Ogino et al., 1985). A series of experiments was conducted with dentin separated from unerupted and supernumerary teeth of various ages in an attempt to evaluate the advantages and limitations of this age-estimation method. The current study on nine tooth specimens showed that some unerupted permanent teeth with normal-sized and -shaped crowns (impacted third molar, canine, and incisor) could be used to estimate the age of individuals at the time of death within +/- 4 years. However, supernumerary teeth (mesiodens, paramolar) with extremely tiny (length of crown: 4 approximately 5 mn) and abnormally shaped crowns could not be used for analysis. In such cases, the estimated age of individuals analyzed by the racemization method deviated considerably from their actual age.

Adolescent↗
PubMed1988

Proton magnetic resonance spectroscopic studies of agonal carbohydrate metabolism in rabbit brain.

1H magnetic resonance spectroscopic measurements of cerebral lactate accumulation were used to estimate maximum agonal cerebral glycolytic rate (AGR) after cardiac arrest in 10 rabbits, six of which had received cortical electroshock. In the four control rabbits, mean AGR was 3.1 mumol glucose equivalents/g wet weight/min (standard error of the mean, 0.6), a figure in close agreement with earlier studies by workers using other techniques. AGR depended much more on carbohydrate availability as expressed by terminal blood glucose than on the shock-conditioned state of the glycolytic system reflected by individual rate constants of lactate accumulation. Regardless of shock history, AGR rose with blood glucose as though it were limited only by substrate availability. The unique capability of magnetic resonance spectroscopy to obtain chemically specific time course data noninvasively made these observations possible. The method has considerable potential for further analysis of normal and deranged cerebral metabolism.

Animals↗
PubMed1988

The first epidemic of acute hemorrhagic conjunctivitis due to a coxsackievirus A24 variant in Okinawa, Japan, in 1985-1986.

Epidemics of acute hemorrhagic conjunctivitis due to a coxsackievirus A24 variant occurred in July-November, 1985 and August-October, 1986 in Okinawa Prefecture, Japan. This is the first report of an acute hemorrhagic conjunctivitis epidemic due to a coxsackievirus A24 variant in Japan The epidemic involved most islands of the prefecture. The prefectural surveillance center was notified of 9,952 cases in 1985 and 6,096 cases in 1986 from three sentinel eye clinics. The neutralizing antibody-positive rate against the coxsackievirus A24 variant of the serum samples collected before and immediately after the 1985 epidemic rose from 1.0% to 8.5%. The coxsackievirus A24 variant was isolated from 48 out of 68 conjunctival swabs collected during the epidemics. The isolates were indistinguishable antigenically in the plaque reduction test from the prototype strain, EH24/70, but had a markedly distinct oligonucleotide pattern.

Adolescent↗
PubMed1988

[Estimation of cell viability by FCM using rhodamin 123 and propidum iodide--its application in evaluating the effect of anticancer drugs to tumor cells].

Dual parameter analysis of FCM using rhodamine 123 (R 123) and propidium iodide (PI) has made it easy to estimate cell viability. PI stains only dead cells, whereas R 123 accumulates in the mitochondria of living cells which remain unstained by PI. Therefore the combination of R 123 and PI provides a more accurate estimation of cell viability than the conventional methods of dye exclusion. Cell viability has been estimated by this method in HeLa cells treated with adriamycin in vitro. The usefulness of this analysis is suggested for the evaluation of the effect of anticancer drugs on tumor cells.

Antineoplastic Agents↗
PubMed1988

[An expression of the monoclonal antibody KM-93 reactive antigen in salivary gland tumors].

The expression of the antigen recognized by a monoclonal antibody KM-93 has been examined in salivary gland tumors by means of an immunohistochemical technique. In immunoperoxidase staining, KM-93 reacted strongly with mucoepidermoid carcinomas and papillary adenocarcinomas, but not with adenoid cystic carcinomas. Thus, this antibody may not meet the requirements as a tumor marker. The inner duct-lining cells of a pleomorphic adenoma expressed the antigen whereas its outer myoepithelial cells did not. In normal glands, neither mucous glands nor myoepithelial cells reacted with the antibody but serous glands and ducts stained positive with the antibody. KM-93, it is thought, would be found useful for differential diagnosis and histogenetic studies of salivary gland tumors.

Adenocarcinoma↗
PubMed1988

[The expression of monoclonal antibody KM-93 reactive antigen in human lung carcinoma--an immunohistochemical evaluation].

Using an histochemical technique, the expression of a tumor-associated antigen, recognized by the monoclonal antibody KM-93, has been investigated in 39 cases of human lung cancer. The overall positive rate was found to be 87.2%, this breaking down to 90.9%, 80.0%, and in adenocarcinomas, squamous cell carcinomas, and large cell carcinomas, respectively. In adenocarcinomas, most of the tumor cells stained strongly, while in squamous cell carcinomas, differentiated cells tend to react with the antibody. Even, in tumors judged to be negative, a small fraction of stained cells also was noted. These results suggest the clinical usefulness of this antibody.

Adenocarcinoma↗
PubMed1988

[Hyperthermia in bone and soft tissue tumors].

Local response of hyperthermia for soft tissue and bone tumors was investigated. Ten tumors were superficial tumors and 16 were deep seated tumors; 9 tumors were malignant fibrous histiocytoma, 5 were liposarcoma, 4 were neurogenic and 3 were myogenic sarcoma. The other five tumors were an angiosarcoma, a malignant mesenchymoma, an Ewing's sarcoma, a chordoma and an osteosarcoma. Some 23 tumors were heated in combination with radiation therapy, and 3 were combined with arterial infusion of ADR. Four of 10 superficial tumors disappeared (CR), and, 2 of 10 signified PR. Only one of 16 deep seated tumors showed CR, 3 were PR and 12 showed no response. But 4 of 12 tumors without regression in tumor volume indicated coagulation necrosis owing to histological examinations, and 5 of 12 were regarded as the same response from hypodensity area with CT examination after hyperthermia. Local response rate of of superficial tumors was 60% and that of deep-seated tumors was 81.4%.

Bone Neoplasms↗
PubMed1988

Cleft hand without absence of a finger.

Cleft hand implies a central longitudinal defect. In this paper, six cases of cleft hand with a normal number of digits are reported. Such clefts are less severe than those in which fingers are missing. In our cases, associated anomalies of the upper extremities were cutaneous syndactyly and a more severe cleft hand with an absent finger. Those of the lower extremities were polydactyly, syndactyly, and cleft foot. The clinical features of cleft hand with a normal digital count were similar to those with a missing finger. It is supposed that the teratogenic mechanism of such cleft hands are the same that is the failure of separation of finger rays. Cone shaped cleft of the hand is one of the phenotypes of the anomaly caused by the failure of differentiation of finger rays.

Female↗
PubMed1988

[Metastatic renal tumor originating from esophageal carcinoma: a case report].

A 46-year-old woman with a past history of esophageal carcinoma was hospitalized with the chief complaint of right abdominal pain. Enhanced computed tomography (CT) and selective renal angiography suggested a metastatic renal tumor. Right nephrectomy was performed. Histological examination revealed a renal tumor originated from esophageal squamous cell carcinoma. Metastatic renal tumors are frequently observed at autopsy, but clinically they are extremely uncommon. Thirty-four clinical cases of metastatic renal tumors reported in the Japanese literature during these 20 years are discussed including the present case.

Esophageal Neoplasms↗