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Biomedical subjects

T Oda

Publications and source records attributed to T Oda.

At least 703 records · Page 39Linked to original sources
PubMed1983

Metabolic deterioration in shock state and its modulation.

The initial cellular reaction against the deleterious effects of shock-inducing stimuli apparently elevates the energy-producing capacity so that the cell is able to sustain its normal function. Several endocrine events are fundamentally important as triggering factors for this kind of reaction. As the shock state advances, cellular metabolism deteriorates progressively and cellular energy is exhausted. Depression of intracellular cAMP may induce cellular metabolic unresponsiveness to hormonal stimuli. Consistent degradation of high-energy substances, extreme deviation of the redox state in the NAD+-NADH system, and decrease of endogenous key substances such as L-carnitine ultimately may lead to a standstill of cellular enzymatic reactions (Fig. 13). Methods intended to sustain cellular membrane and enzymatic systems may offer the best contribution to the improvement of shock therapy.

Adenine Nucleotides↗
PubMed1983

[Clinical studies on T-1982 (cefbuperazone) in the field of obstetrics and gynecology].

Clinical studies on T-1982 (cefbuperazone) were performed in 20 patients of obstetrics and gynecology, and the following results were obtained. Clinical effect: The effectiveness was 100% (excellent in 5 cases, good in 4 cases) in intrauterine infection, 75% in adnexitis (excellent in 1 case, good in 2 cases, poor in 1 case), 100% in pelveoperitonitis (excellent in 2 cases, good in 2 cases), 0% in parametritis (poor in 1 case) and 100% in Bartholin's abscess (good in 2 cases), with the overall effectiveness rate of 90% (excellent in 8 cases, good in 10 cases, poor in 2 cases). Bacteriological effect: A total of 17 strains was isolated from 12 out of 20 cases. Fourteen out of 17 strains were aerobic organisms (7 of E. coli, 4 of Klebsiella, 2 of S. faecalis and 1 of S. epidermidis) and 3 out of 17 strains were anaerobes (each 1 strain of B. fragilis, P. prevotii and P. anaerobius) and all of them were eliminated. No side effects due to this drug were noted.

Adult↗
PubMed1983

[Evaluation of cancer chemotherapy using rat ovarian cancer induced by DMBA--observation of histologic effects by light and transmission electron microscopy, and changes in vascular system after cis-DDP treatment].

Cis-DDP was administered to 28 rats with ovarian cancer induced by DMBA. Four to five weeks after the treatment, they were sacrificed and the effects of the anticancer agent were evaluated in regard to relative tumor size before and after the treatment, and histologic effects were investigated by light and electron microscopy. Microangiography was also performed to study vascular changes in the tumor. 1. In seven cases, a significant reduction in the tumor size was found after the cis-DDP treatment. 2. Various degrees of histologic effects were observed in either the tumor increased group or the decreased group, and even in the latter group an excellent histologic effect was recognizable. 3. A proliferation of connective tissues presumably played a significant role in the increase of tumor size observed after chemotherapeutic treatment. 4. On transmission electron microscopic observation, it appeared that cell death was indicated by pyknotic nuclei and destruction of cell organella. A reduction in the number of chromatin and ribosomes indicated a decrease in cell activity. 5. Multi-nuclei-giant cells appeared among the connective tissue in one case. 6. On microangiography, the DMBA induced tumor generally showed hypovascularity, and cis-DDP induced reduction in the number of blood vessels.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1983

Antishock effect of gabexate mesilate (FOY).

The antishock effects of gabexate mesilate (FOY) were investigated in rats subjected to hemorrhagic hypotension, with particular attention focused on the stabilizing effects of hepatic lysosomes. The survival time of rats treated with FOY, infused for 2 hours intravenously at a rate of 50 mg/kg/hr, was significantly prolonged, accompanied by a tendency to decreased activity of plasma lysosomal enzymes. FOY, at a concentration of 10(-3) M, exerted a significant decrease in the extralysosomal release of acid phosphatase (15%, P less than 0.05), beta-glucuronidase (25%, P less than 0.05) and cathepsin D (25%, P less than 0.02) following hyposmotic labilization of lysosomes. Although the release of lysosomal enzymes might be counterbalanced by 50 mg/kg/hr of FOY, favorable cytochemical findings indicating stabilization of lysosomal membranes were consistently observed. The data suggest that FOY has antishock properties, and that these properties are caused, at least partially, by the stabilization of lysosomes.

Acid Phosphatase↗
PubMed1983

[Relationship between radiotherapy and tumor immunity in hosts].

There are several opinions which denied therapeutic effects of preoperative irradiation, however, we have obtained favorable results by preoperative irradiation for the advanced breast and stomach cancers. Because we treated them by less-fractionated irradiation method with a large dose instead of conventional fractionated one. We adopted this kind of radiation method for the purpose of enhancing the antigenicity of the cancer cells (that means to inhibit the suppression of immune reaction in hosts). Cases of advanced breast cancer were irradiated with 30 Gy at once or 10 Gy at three times a week (total 30 Gy) by betatron electron and we treated advanced stomach cancer with twice a week method (5 Gy or 3 Gy each time, total 40 Gy) by 6 MV X-ray. Cellular infiltration into the stroma of malignant tumor is able to be considered as cellular immunity of the tumor. The same reaction could be observed in radiotherapy for cancer by using above method. After preoperative irradiation, we examined the resected specimen histopathologically. Remarkable cellular infiltrations into the tumor nests, such as neutrophils, lymphocytes, macrophages and plasma cells were observed and these cellular infiltrations after the preoperative irradiation were more remarkable than the cases without radiotherapy or with conventional fractionated radiotherapy. The abscopal effects could be seen in several cases. Peripheral lymphocytes, T cells, B cells and blastoid formation rate induced by PHA in vitro were all increased after less-fractionated irradiation. The reaction to 4 kinds of immunological skin tests was also enhanced.

Adult↗
PubMed1983

Seroepidemiological studies on the effects of filarial parasites on infestation of adult T-cell leukemia virus in the Goto Islands, Japan.

Patients with filariasis were commonly observed until 1961-1970 in the Goto Islands, an area where adult T-cell leukemia (ATL) is endemic. The positive rate of antibodies to ATL virus-associated antigen among persons with a high antibody titer to filarial antigen was higher than that among persons with a low antibody titer in both sexes. Thus, filarial parasites might have some promoting effects on ATL virus infection and/or ATL virus proliferation among inhabitants in the endemic areas of filariasis and ATL.

Adolescent↗
PubMed1983

[Clinical study on intravenous infusion of micronomicin].

In recent years, aminoglycoside agents as well as beta-lactam antibiotics have been increasingly used with increased incidence of opportunistic infection caused mainly by Gram-negative bacteria. Therefore, we administered micronomicin sulfate (MCR), reportedly lower in nephrotoxicity, at doses of 60 and 120 mg by intravenous drip infusion for 1 and 2 hours to healthy male volunteers and determined the blood level and the urinary recovery rate. The peak of blood level after 1 hour infusion of MCR was 7.3 micrograms/ml in the 60 mg group and 9.5 micrograms/ml in the 120 mg group. T 1/2 (beta) was 3.34 and 2.48 hours respectively. The peak of blood level after 2 hours infusion of MCR was 5.7 micrograms/ml in the 60 mg group and 8.7 micrograms/ml in the 120 mg group. T 1/2 (beta) was 3.36 and 3.71 hours respectively. In the 120 mg group, the urinary recovery rate for the first 24 hours was 53.5% after 1 hour infusion and 60.9% after 2 hours infusion. In the 60 mg group, the rate was higher, 90.1 and 98.6% respectively. It was suggested that intravenous drip infusion of 120 mg of MCR for 1 hour is comparable to intramuscular injection of the same dose. Further, safety and effectiveness of this drug were studied in 7 clinical cases of urological infection. Good results were obtained in 7 clinical cases given 60 or 120 mg of MCR by intravenous drip infusion. Neither side effects nor abnormal laboratory findings were observed in clinical cases.

Adult↗