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Biomedical subjects

T Nishimura

Publications and source records attributed to T Nishimura.

At least 1,477 records · Page 82Linked to original sources
PubMed1982

[Evaluation of left ventricular wall characteristics in ischemic heart disease by cardiac CT examination].

Sixty-one cases with ischemic heart disease were examined with ECG-gated computed tomography (CT), and left ventricular (LV) wall properties were evaluated by the end-diastolic and end-systolic images of LV slices in terms of LV inner wall motion, LV wall thickness change in cardiac cycle and LV wall thinning. 1) Inner wall motion abnormalities of LV were detected by superimposing ED and ES images, and these coincided with angiocardiographic findings in 82% of LV segments, while assessment was difficult in the septal side because of its poor wall motion even in normal cases. In CT examination, both "hypokinesis" and "dyskinesis" in left ventriculography (LVG) were likely to be expressed as "akinesis" due to poor time resolution, causing difficulty in assessing the severity of abnormality. 2) In CT examination, changes in LV wall thickness during cardiac cycle were easily evaluated, especially in the septal segments. LV segments of a poor thickness change were well correlated with those of the abnormal wall motion assessed by LVG in 72% of LV segments. 3) In CT, LV wall contractility was finally evaluated by the combination of inner wall motion and wall thickness change, and the final assessments agreed with those observed in LVG in 84% of LV segments. 4) LV segments of abnormal motion evaluated by both inner wall motion and wall thickness change in CT image were well correlated with those observed by LVG (75%), and were thought to imply severe myocardial ischemia. 5) A great part of LV segments with wall thinning corresponded to the severely impaired wall motion observed in LVG (83%) and clinically identified myocardial infarction (87%). Wall thinning was well correlated with infarction.

Adult↗
PubMed1982

[Myocardial imaging in patients with Kawasaki disease: exercise stress imaging and serial studies].

Thallium-201 myocardial imaging was performed in 80 children with coronary arterial lesions due to Kawasaki disease in order to assess the value of serial and exercise myocardial imagings. In eight of these children, abnormalities of the image were noted. Twenty children had serial thallium studies with an interval of three to 18 months, and five of these showed changes in the image including appearance of a new perfusion defect in one patient and improvement of perfusion defects in four. These changes of the myocardial image were correlated well with coronary angiographic findings obtained within a few days of the isotope studies. It was noted that the changes of the myocardial image were more frequently observed at relatively recent period recovered from Kawasaki disease. Exercise myocardial imaging using a bicycle ergometer was performed in eight children with coronary arterial lesions. In three an evidence of improvement of the myocardial perfusion was noted immediately after exercise as well as on the delayed image. In one patient, a decrease of the perfusion in the apex and inferior wall was noted immediately after exercise. On the observed image, image of the apex improved but that of the inferior wall remained hypoperfused. Thus thallium-201 myocardial imaging was considered to permit the best noninvasive documentation of ongoing myocardial perfusion abnormalities in patients with Kawasaki disease. Exercise myocardial imaging was found to be useful in differentiating the viable from nonviable myocardium. It was to be emphasized that quantitative evaluation by computer-assisted analysis was particularly valuable in detecting small areas and in a comparison of the myocardial images.

Adolescent↗
PubMed1982

[Clinical study of cefsulodin on infectious diseases in otorhinolaryngological field].

The clinical effect of cefsulodin (CFS) on Pseudomonas species infections in otorhinolaryngologic field was studied in 10 patients. The overall clinical effectiveness was 80% (excellent 4, good 4, poor 2). The bacteriological response of CFS against Pseudomonas species was evaluated from 11 strains. Eradication rate of Pseudomonas species was 82%. In 1 case, body temperature was rised after injection. No abnormal laboratory findings, relating to the drug, were observed after treatment.

Adult↗
PubMed1982

[Myocardial imaging in patients with transposition of the great arteries: comparison between Mustard and Rastelli operations].

Thallium-201 myocardial imaging was performed in 21 patients with transposition of the great arteries (TGA). Thirteen patients were studied before operation, eight patients after Mustard operation and five patients after Rastelli operation. Five patients were studied sequentially before and after the surgery. Each image was compared with hemodynamic and angiographic findings in order to assess the usefulness of this method. In the 13 patients with preoperative TGA, it was possible to differentiate TGA with the intact ventricular septum from TGA with associated anomalies such as patent ductus arteriosus or ventricular septal defect, and also TGA with pulmonary hypertension or pulmonary stenosis from TGA without them by evaluating the degree of thallium uptake in the free wall of the pulmonary ventricle (anatomical left ventricle). The degree of thallium uptake was well correlated with systolic pressure of the pulmonary ventricle (r = 0.98). In the 13 patients with postoperative TGA, it was less correlated with the pulmonary ventricular systolic pressure (r = 0.83). Four cases sequentially studied showed a marked decrease in thallium uptake in the pulmonary ventricle 10 to 16 months after Rastelli operation. But the corrected thallium uptake (thallium activity/ventricular systolic pressure) was more increased compared with the uptake of the systemic ventricle after the surgery. This was probably related to a decrease of the pressure load to the pulmonary ventricle following the surgery and to the fact that there should be some delay of a decrease of the ventricular mass. An increased lung uptake of thallium was noted in the cases of tricuspid regurgitation after Mustard operation, but the degree of regurgitation was not clearly correlated with the increase of thallium uptake in the lung. In five cases after Rastelli operation, one patient showed a high degree of thallium uptake of the pulmonary ventricle (anatomical right ventricle), and the conduit valve calcification and severe pulmonary stenosis were confirmed by cardiac catheterization and angiography. Thus myocardial imaging provides a reliable mean for the qualitative and quantitative assessment of TGA before and after operation.

Child, Preschool↗
PubMed1981

Use of chromogenic substrate S-2251 for determination of plasminogen activator in rat ovaries.

A simple specific and reproducible method for determination of plasminogen activator activity in rat ovaries has been developed by using the chromogenic substrate S-2251. The two steps of enzymatic reactions, i.e. activation of plasminogen and subsequent hydrolysis of the substrate was performed in one step incubation. A linear relationship was observed between the amount of chromogen produced and activator activity in the range of the optical density form 0.05 to 1.20 for 30 min's incubation. Endogenous activity of non-specific proteases, plasmin or plasmin inhibitors which might be contained in rat ovaries turned out not to interfere with the specificity of a standardized assay procedure. Reproducibility was firmly established with coefficient of variation not exceeding 10%. Using this method, a marked increase followed by a drastic decrease in the activator activity was shown with rat ovaries around the time of ovulation after the injection of human chorionic gonadotropin.

Animals↗