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Biomedical subjects

T Nishimura

Publications and source records attributed to T Nishimura.

At least 1,351 records · Page 75Linked to original sources
PubMed1984

Diagnosis of submucosal tumor by injecting a water soluble contrast medium: development pattern and growing of tumors.

With the application of our endoscopical method of contrasted X-ray imaging, gastric submucosal tumors were studied with chief regards to their modes of growing up and patterns of development. It has become known that, of extra-gastric developing tumors, larger ones tend to show Pattern IVa and smaller ones Pattern IVb. Generally, the tumors showed a tendency of becoming larger in older patients. Periodical checking disclosed about 15% of the tumors growing larger with the lapse of time. It has been surmised that as tumors grow up, their development possibly turns from intra-gastric to intramural and mingled in pattern. Their modes of growing could be classified as follows: Abruptly growing large at a certain time and then remaining without notable changes, step-by-step enlarging, and gradually growing up straight forwardly with years.

Adult↗
PubMed1984

Diagnosis of submucosal tumors by injecting a water soluble contrast medium: judgement of tumor developing pattern and endoscopic lumpectomy.

With the remarkable increases in the number of cases of endoscopical removal of submucosal tumors spurred by the application of high-frequency current, it has become more and more important to apply beforehand some reliable methods like ours to differentiate between tumors and other tumescent lesions due to extra-gastric pressure similar in configuration to tumors and also to confirm the development patterns of tumors either intra-gastric or extra-gastric. Such preparatory arrangements seem indispensable to minimize the risk of perforation incidental to the endoscopical treatment of tumors. To cope with another danger of major bleeding following tumor resection, securing on hand an effective hemostatic is indispensable as well. In our care of the patients after their undergoing endoscopical lumpectomies, we usually subject them to quiet rest and fasting for two or three days; then when they are to resume a regular diet, we endoscopically examine them before and after each meal to confirm the presence or absence of bleeding. In 12 subjects of this series treated with our routine and finally with lumpectomies for gastric submucosal tumors, no serious adverse reactions developed.

Adolescent↗
PubMed1984

Problems in localization of bleeding sites and the incidence of varicose rupture in emergency endoscopy.

An investigation was made for problems involved in identification of bleeding sites and the incidences of bleeding from esophageal and gastric varices in emergency endoscopy within 24 hr after overt gastrointestinal bleeding. Varices or ulcers are not always the source of bleeding, and endoscopic examinations should be performed early after the onset of bleeding to make correct identification of the bleeding site. For such purposes, aspiration using endoscopy, washing under direct observation using a teflon tube and changing of body posture were found effective. During the 6 years from 1977, bleeding from the esophageal or gastric varices was detected in 4 cases out of 30 cases of esophageal or gastric varices which had undergone emergency endoscopy for overt bleeding. After June, 1979, when hemostatic measure using pure ethanol was applied actively, bleeding from esophageal or gastric varices was observed in 4 cases (2.5%) out of 160 cases. Results of the present emergency endoscopy revealed that the incidence of rupture of varices was not so high as had been expected conventionally.

Emergencies↗
PubMed1984

Bacterial uptake of habekacin, a novel aminoglycoside antibiotic.

Cellular uptake of habekacin, 1-N-(4-amino-2-hydroxybutyryl)dibekacin, was studied by incubating exponentially growing culture of Escherichia coli Q13 and its kanamycin-resistant mutants with [3H]habekacin. Kanamycin-resistant mutants, in which the resistance is due to alteration of ribosomes, were cross-resistant to habekacin, and showed a lower uptake of [3H]habekacin than the parental cells, suggesting that binding to ribosomes accelerates cellular uptake of habekacin. Cellular accumulation of [3H]habekacin by wild type cells was markedly inhibited by low temperature and by 2,4-dinitrophenol, suggesting that uptake of habekacin involves energy-dependent transport. The uptake of [3H]habekacin was reduced by various aminoglycoside antibiotics, suggesting common transport systems and/or common internal binding sites on the ribosome. Intracellular accumulation of [3H]dibekacin was reduced by habekacin, suggesting that both antibiotics possess a common transport system and/or common binding sites on the ribosome. Dibekacin was a better competitor than amikacin, suggesting that the dibekacin moiety of habekacin molecule, but not the 4-amino-2-hydroxybutyryl moiety, participates in the transport and/or binding to the ribosome. Binding of [3H]habekacin to E. coli ribosomes was reversed by various aminoglycosides and the degree of inhibition paralleled the one of cellular uptake, suggesting that competition by aminoglycosides for the habekacin uptake occurs at the ribosomal level.

2,4-Dinitrophenol↗
PubMed1984

Isolation, drug sensitivity, and some biochemical and genetical properties of macromomycin-resistant mouse lymphoblastoma L5178Y cells.

A macromomycin (MCR)-resistant subline of mouse lymphoblastoma L5178Y cells was isolated after successive treatment of tumor-bearing mice with the antibiotic for 7 transplant generations, followed by cloning in culture in MCR-containing soft agar medium. The resistant cell line was about 17 times more resistant to MCR than was the parental cell line and exhibited cross-resistance to neocarzinostatin, mitomycin C and adriamycin in a similar degree to MCR. No significant cross-resistance was observed with aclarubicin, bleomycin and neothramycin. Alkaline phosphodiesterase activity in the plasma membrane of resistant cells was higher than that of parental cells. Uptake and efflux studies with [3H]adriamycin suggested that the resistance is due to decreased uptake and increased efflux of the antibiotic in resistant cells. Hybridization studies with MCR-sensitive and -resistant cells showed that the MCR resistance is a codominant trait in somatic cell hybrids.

Animals↗
PubMed1984

[Chemotherapy of disseminated germ cell testicular tumors with cis-diamminedichloroplatinum and other drugs].

The effect of single CDDP therapy and PVB therapy was examined in 7 cases of stage III germ cell testicular tumors with measurable metastases. The mean age of the patients was 30.6 years old, and their histological types of primary sites were seminoma in 3 cases, embryonal carcinoma in 2, immature teratoma in 1 case and embryonal carcinoma + teratoma in 1 case. In 1 case of seminoma, 375 mg of CDDP was administered. In 1 case of embryonal carcinoma + teratoma, 100 mg of CDDP and then 2 courses of PVB therapy were performed, and 3 courses of PVB therapy were given in all other cases. Three cases showed complete response, 2 cases partial response and 2 cases no change. Pulmonary metastatic nodules were extirpated after the PVB therapy in 1 of the cases showing no change, and the histological examination of these nodules was found to be mature teratoma. As a result, the effectiveness of the chemotherapy alone was 71.4%, and that of chemotherapy + surgical operation was 85.7%. Significance of intensive chemotherapy and necessity of extirpation of residual metastatic nodules after intensive chemotherapy in the management of advanced germ cell testicular tumors are stressed.

Adult↗
PubMed1984

[Chemotherapy of metastatic renal cell carcinoma with cis-diamminedichloroplatinum and other drugs].

Seven patients were entered in this study between November 1978 and February 1983. All patients had histologically proven renal cell carcinoma with widespread metastases. Patients ranged in age from 27 to 69 years, with an average of 54 years. All those studied had measurable radiological lesions of malignant disease. One patient was treated with only CDDP and the other 6 patients were treated with CDDP and other anti-cancer drugs (vinblastine, ifosfamide, bleomycin and/or adriamycin). Total doses of CDDP ranged from 20 to 250 mg, with an average of 99 mg. Four cases showed no change and 3 patients had progressive disease. Symptomatic improvement was obtained in only 2 patients. Management of metastatic renal cell carcinoma is discussed briefly.

Adult↗
PubMed1984

[Laboratory and clinical studies of sulbactam/cefoperazone in the pediatric field].

The authors have carried out the laboratory and clinical studies of sulbactam/cefoperazone (SBT/CPZ) and obtained the following results. The antibacterial activities of SBT/CPZ against the clinical isolates of S. aureus, E. coli, K. pneumoniae, E. cloacae, E. aerogenes, S. marcescens, P. aeruginosa were measured by the plate dilution method with inoculum size of 10(6) cells/ml. The susceptibility distribution of S. aureus to SBT/CPZ ranged from 0.39 to 6.25 micrograms/ml, and the peak of distribution was 1.56 micrograms/ml. The peak of susceptibility distribution of K. pneumoniae was 0.20 microgram/ml, and the distribution of E. coli and E. aerogenes ranged from 0.10 to 12.5 micrograms/ml and that of S. marcescens, from 0.2 to 25 micrograms/ml. The growth of 80.8% of P. aeruginosa was inhibited at the concentration of 12.5 micrograms/ml. The distribution of E. cloacae ranged from 0.1 to 50 micrograms/ml. For pharmacokinetic study, SBT/CPZ was given in a single dose of 20 mg/kg by drip infusion for 1 hour in 2 children and 40 mg/kg by drip infusion for 1 hour in 1 children. With drip infusion of SBT/CPZ, the peak serum level were 17.8/43.9 micrograms/ml, 21.8/75.5 micrograms/ml on completion of the infusion, respectively. SBT/CPZ was effective in 14 cases out of 16 cases with clinical effect. No side effect was observed except for eosinophilia in 1 case.

Adolescent↗
PubMed1984

[Carcinoma of urachus: report of 3 cases and review of literature].

Three cases of urachal carcinoma are presented. Chief complaints were passage of mucous urine in a 58-year-old man (case 1), hematuria and frequency in a 63-year-old woman (case 2) and hematuria in a 45-year-old man (case 3). Urine cytology were negative for all cases and serum CEA level was elevated in case 1. Mass in the area of the bladder dome were revealed by cystoscopic examination in all cases. CT scanning, TUR biopsy and cystogram were valuable diagnostic procedure. En bloc segmental resection were performed on all cases, and case 1 and case 2 have been well without disease for 36 and 40 months, respectively. Case 3 died 65 months after operation with disseminated carcinoma. Histologically mucin-producing adenocarcinoma were found in all cases. Statistic examination and discussion are made of 237 cases of urachal carcinoma reported in Japan.

Adenocarcinoma, Mucinous↗
PubMed1984

[Laboratory and clinical studies of ceftriaxone in the pediatric field].

The authors have carried out the laboratory and clinical studies of ceftriaxone (Ro 13-9904, CTRX) and obtained the following results. The antibacterial activities of CTRX against the clinical isolates of S. aureus, E. coli, K. pneumoniae, E. cloacae, E. aerogenes, S. marcescens, Citrobacter sp. and P. aeruginosa were measured by the agar dilution method with inoculum size of 10(6) cells/ml. The susceptibility distribution of S. aureus to CTRX ranged from 0.2 to 12.5 micrograms/ml, and the peak of distribution was 3.13 micrograms/ml. The peak of susceptibility distribution of E. coli and K. pneumoniae were 0.1 microgram/ml or lower, and the distribution of E. aerogenes and E. cloacae ranged from 0.1 to 100 micrograms/ml, Citrobacter sp. and S. marcescens, from 0.1 to 12.5 micrograms/ml and that of P. aeruginosa, from 0.39 to 100 micrograms/ml or more. For pharmacokinetic study, CTRX was given in a single dose of 10 mg/kg in 1 child and 20 mg/kg in 2 children by drip infusion for 1 hour. After drip infusion of CTRX in a single dose of 10 mg/kg, the peak serum level was 61.4 micrograms/ml on completion of the infusion, and 8.43 micrograms/ml at 12 hours. Half-life time was 4.6 hours. With drip infusion of CTRX in a single dose of 20 mg/kg, the peak serum level was 105.5 micrograms/ml on completion of the infusion, and 19.1 micrograms/ml at 12 hours. Half-life time was 8.7 hours. CTRX was effective all cases out of 8 cases with bacterial infection. No side effect was observed except for elevation of serum GOT in 2 cases and eosinophilia in 1 case.

Bacteria↗
PubMed1984

Induction of nonspecific killer T cells from non-immune mouse spleen cells by culture with interleukin 2.

Culture fluids of concanavalin A-stimulated rat spleen cells were purified by means of ammonium sulfate precipitation and Sephacryl S-200 column chromatography. Interleukin 2 (IL-2), which can promote the proliferation of mouse lymphocytes was distributed in the fractions of molecular weight of 22,000 to 26,000 daltons. Culture of C57BL/6 mouse spleen cells with the IL-2 fraction resulted in the induction of cells cytotoxic to syngeneic fibrosarcoma cells. Determination of the target specificity of the killer cells revealed that the killer cells could lyse a variety of syngeneic and allogeneic tumor cells in vitro. The results of cold target inhibition tests and cytotoxicity assay after treatment with antisera plus complement indicated that the killer cells mainly consisted of Thy 1.2+, Ly 2.2+, asialoGM1-T cells but included some asialo-GM1+ natural killer (NK) cells. Although the cytotoxicities of both IL-2-activated killer T cells and NK cells were nonspecific in terms of the antigen specificity, their cytotoxic activities against syngeneic fibrosarcomas and NK-sensitive allogeneic lymphomas were complementary. The assay of interferon in culture fluid from IL-2-treated spleen cells suggested that generation of IL-2-activated killer cells was closely associated with the amount of immune interferon released from lymphocytes in the culture.

Animals↗
PubMed1984

[Case of immature teratoma of the testicle metastasizing as completely mature teratoma].

A case of immature teratoma of the testicle metastasizing as completely mature teratoma is presented. A 23-year-old man underwent right inguinal orchiectomy for an immature teratoma of the testicle on September 14, 1982. At retroperitoneal lymph node dissection, 12 lymph nodes were removed, all of which were negative for cancer. He was well until March 1983, when bloody sputum and left chest pain occurred. Since full lung tomography revealed two pulmonary nodules, he was treated with a course of VP-16 and three courses of vinblastine, bleomycin and CDDP. In September 1983, after completion of the combination chemo-therapy, the two pulmonary nodules were noticed to be slightly enlarging. A thoracotomy was scheduled to remove these nodules, since they were believed to be his only remaining tumors. Pathologic examination of the extirpated nodules disclosed completely benign teratoma. Mediastinal lymph nodes had no metastatic involvement histologically. It is our intention in this paper to emphasize, by means of several case reports, the frequently benign nature of these residual lesions and also to emphasize a recently recognized phenomenon--the apparent induction of benign teratomas by this intensive chemotherapy.

Adult↗
PubMed1984

[A case of renal carcinoma with bone metastasis, producing alpha-fetoprotein].

A 54-year-old man was admitted with the complaint of severe lumbago, pain in the right shoulder and difficulty in walking. Laboratory tests showed markedly increased alpha-fetoprotein (AFP) level (600 ng/ml) and tomography demonstrated osteolytic lesion of the 5th lumbar vertebra and right scapula. Needle biopsy of the 5th lumbar vertebra revealed only necrotic tissue pathologically. Liver scan and whole body CT did not show any abnormality except for a right renal mass. Hypervascular tumor at the lower pole of the right kidney was noted by IVP and selective renal angiography. No pulmonary metastasis was found. The patient underwent transabdominal right nephrectomy. He had a lowered level of AFP (300 ng/ml) on the 17th post operative day. AFP level dropped further to 100 ng/ml after administration of vinblastine and ifosfamide. Lumbago continued without improving, and the patient died at home 20 weeks after surgery due to general weakness. Although we did not perform radiological examination of gastro-intestinal tract or autopsy, we concluded that renal cancer and/or a metastatic lesion to bone produced AFP because of the following reasons. No other tumor was detected by liver scan, whole body CT, laboratory examinations, operation or clinical symptoms. The AFP level was lowered after nephrectomy, and further dropped with chemotherapy. A case of renal cancer with bone metastasis and without liver metastasis, producing AFP was reported in the Japanese literature in 1983.

Humans↗