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Biomedical subjects

T Nishimaki

Publications and source records attributed to T Nishimaki.

172 records · Page 10Linked to original sources
PubMed1979

Hanganutziu-Deicher antigen and antibody in pathologic sera and tissues.

Heterophile, Hanganutziu-Deicher (H-D) antigen was studied in pathologic sera by means of inhibition of agglutination of bovine erythrocytes by H-D antibodies. H-D antigen was demonstrated in 38% of random cancer sera, 25% of lymphoma or leukemia sera, 25% of leprosy sera, 8% of infectious mononucleosis sera, 6% of rheumatoid arthritis sera, and 27% of synovial fluids of rheumatoid arthritis patients. None of 134 normal human sera gave positive results. Some of the inhibition-positive cancer sera formed precipitation lines with H-D antibody-containing sera. Over 50% of various extracts of cancer tissues as well as spleens of lymphoma or leukemia patients were shown to contain H-D antigen by means of the inhibition test.

Animals↗
PubMedDate not supplied

Studies on heterophile antibodies in rheumatoid arthritis.

Sera and synovial fluids of patients with rheumatoid arthritis were studied for the presence of heterophile antibodies to sheep and bovine erythrocytes by means of hemolysis in agar gel. It was demonstrated that 18 of 146 sera had hemolytic antibody titers of 160 or more; all 18 (12%) against sheep and 8 (6%) against bovine erythrocytes. Of 31 synovial fluids examined, 5 showed hemolysin titers of 40 or more; all 5 (16%) against sheep and 3 (10%) against bovine erythrocytes. These heterophile antibodies were shown to belong to IgM and/or IgG class. Absorption and inhibition studies revealed that antibodies of 10 positive sera and 2 synovial fluids were of Forssman specificity and antibodies of 6 sera and 3 synovial fluids were of Hanganutziu-Deicher specificity. Two remaining sera were shown to contain a mixture of Forssman antibodies and immune anti-B antibodies.

Absorption↗
PubMedDate not supplied

Studies on immune complexes in rheumatoid arthritis.

Sera and synovial fluids of patients with rheumatoid arthritis were studied for immune complexes by means of the anti-antibody inhibition test; approximately 40% of these specimens were shown to contain immune complexes. To study the nature of antigens participating in the formation of complexes under investigation, the anti-antibody inhibition test was repeated after addition of various soluble antigens to the complex-positive rheumatoid arthritis sera. This resulted in conversion of some sera from inhibitory to noninhibitory. It was found that of 15 positive rheumatoid arthritis sera, 7 had complexes formed by heterophile, Hanganutziu-Deicher antigen and of 12 positive sera tested, 2 had complexes formed by human IgG.

Antigen-Antibody Complex↗
PubMedDate not supplied

Tumor spread in superficial esophageal cancer: histopathologic basis for rational surgical treatment.

To formulate a rational approach for the surgical treatment of patients with superficial esophageal cancer (SEC), tumor spread was clinicopathologically studied in 89 patients with SEC. There were 31 mucosal and 58 submucosal tumors. Lymph node metastases were not found in any of those with a mucosal tumor, while one or more lymph nodes were positive for cancer in 41.4% of those with a submucosal tumor. Furthermore, cancer metastasized to extramediastinal nodes, including cervical and abdominal nodes, in 14 patients, accounting for 58.3% of those with nodal metastasis. The 5-year survival rate was 100% and there were no recurrences after esophagectomy in those with a mucosal tumor, whereas the survival rate of those with a submucosal tumor was 64.3% at 5 years (p < 0.01). Based on the different biological behavior of mucosal and submucosal esophageal cancer, we conclude that mucosal tumors may be adequately treated by any type of local resection but submucosal tumors require a subtotal esophagectomy with systematic lymphadenectomy involving the cervical, mediastinal, and abdominal nodes for cure.

Adult↗
PubMedDate not supplied

Histogenesis and clinicopathological characteristics of superficially spreading carcinoma of the esophagus.

To explore the possible histogenesis of superficially spreading carcinoma of the esophagus, the clinicopathological features of these tumors (n = 44) were compared with those of ordinary superficial carcinoma (n = 163). Tumors of a heterogeneous histological type and having in situ carcinoma components were significantly more common (P < .05), and the number of residual squamous islands was significantly greater (P < 0.05) in the former group than the latter. Furthermore, the tumor size was not different among in situ, intramucosal, and submucosal carcinomas of the former, whereas the tumors became larger according to the depth of invasion in the latter group. These results indicate that the collision of multiple simultaneously developing superficial tumors is a plausible histogenesis of superficially spreading carcinoma of the esophagus.

Aged↗
PubMedDate not supplied

Carcinomas involving the esophagogastric junction (EGJ-Ca). A reevaluation of the criteria.

The present study aims to elucidate more clearly the definition and criteria for carcinomas involving the esophagogastric junction (EGJ-Ca) from a practical viewpoint based on the concept that an EGJ-Ca is a separate surgical disease entity different from either a lower-esophageal or an upper-gastric carcinoma. Among a series of 397 cases of upper-gastric carcinoma and EGJ-Ca resected during a 31-year period between 1963 and 1993, 79 patients with EGJ-Ca (EGJ-Index ranging between 250 and 750) were selected according to lesions with the central point confined within the EGJ-zone 20 mm each proximal and distal to the EGJ-line. Selected for the control group were 97 patients with upper-gastric carcinoma that was strictly confined within the upper third segment of the stomach without involving the EGJ-line upward or the middle third segment downward and with the central point of lesions outside the EGJ-zone. The comparative analysis indicated that an EGJ-Ca might be well defined not only by the EGJ-Index, but also by the EGJ-zone and the localization of the central points of lesions confined within the EGJ-zone. The definition and criteria for EGJ-Ca were thus modified from those of the previous proposal and proposed in this study with three main factors: (1) the EGJ-Index, (2) the EGJ-zone, and (3) the localization of the central point of lesions.

Adult↗